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A Bayesian predictive processing account of Othello syndrome in Parkinson's disease.

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Title: A Bayesian predictive processing account of Othello syndrome in Parkinson's disease.
Authors: Foley, Jennifer A. (AUTHOR), Chen, Cliff (AUTHOR), Paget, Andrew (AUTHOR), Cipolotti, Lisa (AUTHOR)
Source: Cognitive Neuropsychiatry. Jul2023, Vol. 28 Issue 4, p269-284. 16p. 1 Diagram.
Subjects: Parkinson's disease, Delusions, Syndromes, Cognition disorders, Cognitive therapy
Abstract: Introduction: Although delusions in Parkinson's disease (PD) are rare, when they occur they frequently take the form of "Othello syndrome": the irrational belief that a spouse or partner is being unfaithful. Hitherto dismissed as either a by-product of dopamine therapy or cognitive impairment, there are still no convincing theoretical accounts to explain why only some patients fall prey to this delusion, or why it persists despite clear disconfirmatory evidence. Methods: We discuss the limitations of existing explanations of this delusion, namely hyperdopaminergia-induced anomalous perceptual experiences and cognitive impairment, before describing how Bayesian predictive processing accounts can provide a more comprehensive explanation by foregrounding the importance of prior experience and its impact upon computation of probability. We illustrate this new conceptualisation with three case vignettes. Results: We suggest that in those with prior experience of romantic betrayal, hyperdominergic-induced aberrant prediction errors enable anomalous perceptual experiences to accrue greater prominence, which is then maintained through Bayes-optimal inferencing to confirm cognitive distortions, eliciting and shaping this dangerous delusion. Conclusions: We propose the first comprehensive mechanistic account of Othello syndrome in PD and discuss implications for clinical interventions. [ABSTRACT FROM AUTHOR]
Copyright of Cognitive Neuropsychiatry is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: A Bayesian predictive processing account of Othello syndrome in Parkinson's disease.
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  Data: <searchLink fieldCode="AR" term="%22Foley%2C+Jennifer+A%2E%22">Foley, Jennifer A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+Cliff%22">Chen, Cliff</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Paget%2C+Andrew%22">Paget, Andrew</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cipolotti%2C+Lisa%22">Cipolotti, Lisa</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Cognitive+Neuropsychiatry%22">Cognitive Neuropsychiatry</searchLink>. Jul2023, Vol. 28 Issue 4, p269-284. 16p. 1 Diagram.
– Name: Subject
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  Data: <searchLink fieldCode="DE" term="%22Parkinson's+disease%22">Parkinson's disease</searchLink><br /><searchLink fieldCode="DE" term="%22Delusions%22">Delusions</searchLink><br /><searchLink fieldCode="DE" term="%22Syndromes%22">Syndromes</searchLink><br /><searchLink fieldCode="DE" term="%22Cognition+disorders%22">Cognition disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Cognitive+therapy%22">Cognitive therapy</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Introduction: Although delusions in Parkinson's disease (PD) are rare, when they occur they frequently take the form of "Othello syndrome": the irrational belief that a spouse or partner is being unfaithful. Hitherto dismissed as either a by-product of dopamine therapy or cognitive impairment, there are still no convincing theoretical accounts to explain why only some patients fall prey to this delusion, or why it persists despite clear disconfirmatory evidence. Methods: We discuss the limitations of existing explanations of this delusion, namely hyperdopaminergia-induced anomalous perceptual experiences and cognitive impairment, before describing how Bayesian predictive processing accounts can provide a more comprehensive explanation by foregrounding the importance of prior experience and its impact upon computation of probability. We illustrate this new conceptualisation with three case vignettes. Results: We suggest that in those with prior experience of romantic betrayal, hyperdominergic-induced aberrant prediction errors enable anomalous perceptual experiences to accrue greater prominence, which is then maintained through Bayes-optimal inferencing to confirm cognitive distortions, eliciting and shaping this dangerous delusion. Conclusions: We propose the first comprehensive mechanistic account of Othello syndrome in PD and discuss implications for clinical interventions. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Cognitive Neuropsychiatry is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1080/13546805.2023.2229080
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      – Code: eng
        Text: English
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        StartPage: 269
    Subjects:
      – SubjectFull: Parkinson's disease
        Type: general
      – SubjectFull: Delusions
        Type: general
      – SubjectFull: Syndromes
        Type: general
      – SubjectFull: Cognition disorders
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      – SubjectFull: Cognitive therapy
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            – D: 01
              M: 07
              Text: Jul2023
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              Y: 2023
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