Postoperative de novo epilepsy after resection of brain arteriovenous malformations: A national database study of 536 patients.
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| Title: | Postoperative de novo epilepsy after resection of brain arteriovenous malformations: A national database study of 536 patients. |
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| Authors: | Sioutas, Georgios S. (AUTHOR), Palepu, Chandrasekhar (AUTHOR), Salem, Mohamed M. (AUTHOR), Nia, Anna M. (AUTHOR), Vivanco‐Suarez, Juan (AUTHOR), Burkhardt, Jan‐Karl (AUTHOR), Jankowitz, Brian T. (AUTHOR), Srinivasan, Visish M. (AUTHOR) |
| Source: | Epilepsia (Series 4). Nov2023, Vol. 64 Issue 11, p2914-2921. 8p. |
| Subjects: | Cerebral arteriovenous malformations, Temporal lobectomy, Epilepsy, Databases, Propensity score matching, Cerebral hemorrhage |
| Abstract: | Objective: We aimed to assess the incidence and risk factors for de novo epilepsy after arteriovenous malformation (AVM) resection and compare them with a nonresection cohort after propensity score matching, utilizing a national database. Methods: Utilizing the TriNetX Research Network, we queried cases from January 1, 2004 to March 1, 2022. We included patients of all ages who underwent supratentorial AVM resection, presenting without seizures on or before surgery and without being on antiseizure medications at least 1 day before surgery. The primary outcome was seizures manifesting at least 6 weeks after surgery. Patient characteristics and outcomes were compared between the cohorts with and without postoperative epilepsy. Further cohorts were created to compare cohorts with and without embolization or rupture. After propensity score matching, we compared an additional cohort of patients with an AVM diagnosis who did not undergo resection. Results: Of the 536 patients (mean age = 38.9 ± 19.6, 52% females) presenting without seizure who underwent AVM resection, 99 (18.5%) developed de novo epilepsy, with a 1‐year cumulative incidence of 13.8%. Patients with epilepsy had higher rates of intracerebral hemorrhage, and intracerebral hemorrhage was less common in the embolization cohort. Patients in the ruptured cohort were older and more often males. After propensity score matching with 18 588 patients with AVM diagnosis but no resection, each group consisted of 529 patients, and de novo epilepsy at 1 year was significantly higher in the AVM resection cohort compared to the nonresection cohort (11.5% vs. 3.4%, p <.001). Significance: This analysis of 536 patients provides evidence that de novo epilepsy after brain AVM resection occurs at a 1‐year cumulative incidence of 13.8%, with a total of 19.4% developing de novo epilepsy. Intracerebral hemorrhage was inconsistently associated with postoperative de novo epilepsy. De novo epilepsy was significantly less frequent after AVM diagnosis without resection. [ABSTRACT FROM AUTHOR] |
| Copyright of Epilepsia (Series 4) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 173454332 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Postoperative de novo epilepsy after resection of brain arteriovenous malformations: A national database study of 536 patients. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Sioutas%2C+Georgios+S%2E%22">Sioutas, Georgios S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Palepu%2C+Chandrasekhar%22">Palepu, Chandrasekhar</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Salem%2C+Mohamed+M%2E%22">Salem, Mohamed M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nia%2C+Anna+M%2E%22">Nia, Anna M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vivanco‐Suarez%2C+Juan%22">Vivanco‐Suarez, Juan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Burkhardt%2C+Jan‐Karl%22">Burkhardt, Jan‐Karl</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jankowitz%2C+Brian+T%2E%22">Jankowitz, Brian T.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Srinivasan%2C+Visish+M%2E%22">Srinivasan, Visish M.</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Epilepsia+%28Series+4%29%22">Epilepsia (Series 4)</searchLink>. Nov2023, Vol. 64 Issue 11, p2914-2921. 8p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Cerebral+arteriovenous+malformations%22">Cerebral arteriovenous malformations</searchLink><br /><searchLink fieldCode="DE" term="%22Temporal+lobectomy%22">Temporal lobectomy</searchLink><br /><searchLink fieldCode="DE" term="%22Epilepsy%22">Epilepsy</searchLink><br /><searchLink fieldCode="DE" term="%22Databases%22">Databases</searchLink><br /><searchLink fieldCode="DE" term="%22Propensity+score+matching%22">Propensity score matching</searchLink><br /><searchLink fieldCode="DE" term="%22Cerebral+hemorrhage%22">Cerebral hemorrhage</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Objective: We aimed to assess the incidence and risk factors for de novo epilepsy after arteriovenous malformation (AVM) resection and compare them with a nonresection cohort after propensity score matching, utilizing a national database. Methods: Utilizing the TriNetX Research Network, we queried cases from January 1, 2004 to March 1, 2022. We included patients of all ages who underwent supratentorial AVM resection, presenting without seizures on or before surgery and without being on antiseizure medications at least 1 day before surgery. The primary outcome was seizures manifesting at least 6 weeks after surgery. Patient characteristics and outcomes were compared between the cohorts with and without postoperative epilepsy. Further cohorts were created to compare cohorts with and without embolization or rupture. After propensity score matching, we compared an additional cohort of patients with an AVM diagnosis who did not undergo resection. Results: Of the 536 patients (mean age = 38.9 ± 19.6, 52% females) presenting without seizure who underwent AVM resection, 99 (18.5%) developed de novo epilepsy, with a 1‐year cumulative incidence of 13.8%. Patients with epilepsy had higher rates of intracerebral hemorrhage, and intracerebral hemorrhage was less common in the embolization cohort. Patients in the ruptured cohort were older and more often males. After propensity score matching with 18 588 patients with AVM diagnosis but no resection, each group consisted of 529 patients, and de novo epilepsy at 1 year was significantly higher in the AVM resection cohort compared to the nonresection cohort (11.5% vs. 3.4%, p <.001). Significance: This analysis of 536 patients provides evidence that de novo epilepsy after brain AVM resection occurs at a 1‐year cumulative incidence of 13.8%, with a total of 19.4% developing de novo epilepsy. Intracerebral hemorrhage was inconsistently associated with postoperative de novo epilepsy. De novo epilepsy was significantly less frequent after AVM diagnosis without resection. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Epilepsia (Series 4) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=173454332 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/epi.17765 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 8 StartPage: 2914 Subjects: – SubjectFull: Cerebral arteriovenous malformations Type: general – SubjectFull: Temporal lobectomy Type: general – SubjectFull: Epilepsy Type: general – SubjectFull: Databases Type: general – SubjectFull: Propensity score matching Type: general – SubjectFull: Cerebral hemorrhage Type: general Titles: – TitleFull: Postoperative de novo epilepsy after resection of brain arteriovenous malformations: A national database study of 536 patients. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Sioutas, Georgios S. – PersonEntity: Name: NameFull: Palepu, Chandrasekhar – PersonEntity: Name: NameFull: Salem, Mohamed M. – PersonEntity: Name: NameFull: Nia, Anna M. – PersonEntity: Name: NameFull: Vivanco‐Suarez, Juan – PersonEntity: Name: NameFull: Burkhardt, Jan‐Karl – PersonEntity: Name: NameFull: Jankowitz, Brian T. – PersonEntity: Name: NameFull: Srinivasan, Visish M. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 11 Text: Nov2023 Type: published Y: 2023 Identifiers: – Type: issn-print Value: 00139580 Numbering: – Type: volume Value: 64 – Type: issue Value: 11 Titles: – TitleFull: Epilepsia (Series 4) Type: main |
| ResultId | 1 |
