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Abnormal white matter along fibers by automated fiber quantification in patients undergoing hemodialysis.

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Title: Abnormal white matter along fibers by automated fiber quantification in patients undergoing hemodialysis.
Authors: Chen, Hui Juan (AUTHOR), Qiu, Jie (AUTHOR), Xu, Xiaoling (AUTHOR), Guo, Yihao (AUTHOR), Fu, Lili (AUTHOR), Fu, Qingqing (AUTHOR), Wu, Yanglei (AUTHOR), Qi, Yonghui (AUTHOR), Chen, Feng (AUTHOR)
Source: Neurological Sciences. Dec2023, Vol. 44 Issue 12, p4499-4509. 11p.
Subjects: White matter (Nerve tissue), Hemodialysis patients, Diffusion tensor imaging, Chronic kidney failure, Pyramidal tract, Hemodialysis
Abstract: Background: Abnormal white matter has been reported in patients with end-stage renal disease (ESRD). However, few studies have investigated the relationship between specific damage segments and cognition in ESRD. This study aimed to delineate white matter alterations in ESRD and its relationship with cognition. Methods: A total of 36 patients undergoing hemodialysis and 25 healthy controls underwent diffusion tensor imaging (DTI) and a series of neuropsychiatric tests. Automated fiber quantification was used to extract distinct DTI indices, and the relationship between the specific segment of the white matter and clinical properties was investigated. Furthermore, a support vector machine was applied to differentiate patients with ESRD from healthy controls. Results: Fractional anisotropy values decreased in multiple fiber bundles, including bilateral thalamic radiata, cingulum cingulate, inferior fronto-occipital fasciculus (IFOF), uncinate, Callosum_Forceps_Major/Callosum_Forceps_Minor (CFMaj/CFMin), and left uncinate from the tract level in patients with ESRD. Specific damaged segments were detected in 8 fiber bundles, including bilateral thalamic radiation, cingulum cingulate, IFOF, CFMin, and left corticospinal tract. Few alterations in these fiber bundles were correlated with cognition impairment and hemoglobin levels. The tract profiles of the left thalamic radiata and left cingulum cingulate could be used to differentiate hemodialysis patients from healthy controls, with an accuracy of 76.9% and 67.6%, respectively. Conclusions: This study revealed white matter damage in hemodialysis patients. This damage occurred in specific segments of the tract, especially in the left thalamic radiata and left cingulum cingulate, which might become a new biomarker for patients with ESRD and cognition impairment. [ABSTRACT FROM AUTHOR]
Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Abnormal white matter along fibers by automated fiber quantification in patients undergoing hemodialysis.
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  Data: <searchLink fieldCode="AR" term="%22Chen%2C+Hui+Juan%22">Chen, Hui Juan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Qiu%2C+Jie%22">Qiu, Jie</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Xu%2C+Xiaoling%22">Xu, Xiaoling</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Guo%2C+Yihao%22">Guo, Yihao</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fu%2C+Lili%22">Fu, Lili</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fu%2C+Qingqing%22">Fu, Qingqing</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wu%2C+Yanglei%22">Wu, Yanglei</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Qi%2C+Yonghui%22">Qi, Yonghui</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+Feng%22">Chen, Feng</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. Dec2023, Vol. 44 Issue 12, p4499-4509. 11p.
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  Data: <searchLink fieldCode="DE" term="%22White+matter+%28Nerve+tissue%29%22">White matter (Nerve tissue)</searchLink><br /><searchLink fieldCode="DE" term="%22Hemodialysis+patients%22">Hemodialysis patients</searchLink><br /><searchLink fieldCode="DE" term="%22Diffusion+tensor+imaging%22">Diffusion tensor imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Chronic+kidney+failure%22">Chronic kidney failure</searchLink><br /><searchLink fieldCode="DE" term="%22Pyramidal+tract%22">Pyramidal tract</searchLink><br /><searchLink fieldCode="DE" term="%22Hemodialysis%22">Hemodialysis</searchLink>
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  Data: Background: Abnormal white matter has been reported in patients with end-stage renal disease (ESRD). However, few studies have investigated the relationship between specific damage segments and cognition in ESRD. This study aimed to delineate white matter alterations in ESRD and its relationship with cognition. Methods: A total of 36 patients undergoing hemodialysis and 25 healthy controls underwent diffusion tensor imaging (DTI) and a series of neuropsychiatric tests. Automated fiber quantification was used to extract distinct DTI indices, and the relationship between the specific segment of the white matter and clinical properties was investigated. Furthermore, a support vector machine was applied to differentiate patients with ESRD from healthy controls. Results: Fractional anisotropy values decreased in multiple fiber bundles, including bilateral thalamic radiata, cingulum cingulate, inferior fronto-occipital fasciculus (IFOF), uncinate, Callosum_Forceps_Major/Callosum_Forceps_Minor (CFMaj/CFMin), and left uncinate from the tract level in patients with ESRD. Specific damaged segments were detected in 8 fiber bundles, including bilateral thalamic radiation, cingulum cingulate, IFOF, CFMin, and left corticospinal tract. Few alterations in these fiber bundles were correlated with cognition impairment and hemoglobin levels. The tract profiles of the left thalamic radiata and left cingulum cingulate could be used to differentiate hemodialysis patients from healthy controls, with an accuracy of 76.9% and 67.6%, respectively. Conclusions: This study revealed white matter damage in hemodialysis patients. This damage occurred in specific segments of the tract, especially in the left thalamic radiata and left cingulum cingulate, which might become a new biomarker for patients with ESRD and cognition impairment. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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              Text: Dec2023
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