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Prominent mitochondrial pathology in a case of refractory dermatomyositis: coincidence or concause?

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Title: Prominent mitochondrial pathology in a case of refractory dermatomyositis: coincidence or concause?
Authors: Lauletta, Antonio (AUTHOR), De Carolis, Lanfranco (AUTHOR), Teresi, Valentina (AUTHOR), Fionda, Laura (AUTHOR), Leonardi, Luca (AUTHOR), Ceccanti, Marco (AUTHOR), Costanzo, Rocco (AUTHOR), Rossini, Elena (AUTHOR), Tufano, Laura (AUTHOR), Merlonghi, Gioia (AUTHOR), Morino, Stefania (AUTHOR), Garibaldi, Matteo (AUTHOR)
Source: Neurological Sciences. Dec2023, Vol. 44 Issue 12, p4525-4529. 5p.
Subjects: Dermatomyositis, Inclusion body myositis, Polymyositis, Mitochondrial pathology, Muscle weakness, Coincidence, Patient-professional relations
Abstract: Introduction: Mitochondrial alterations are a common finding in muscle biopsy of sporadic inclusion body myositis (s-IBM) and polymyositis with mitochondrial pathology (PM-Mito). Both disorders generally have poor treatment response. Nevertheless, mitochondrial myopathology has been rarely reported in dermatomyositis (DM) outside areas of perifascicular atrophy and a relationship with therapeutic outcome is not established. Methods: We report on clinical, immunological, radiological, and myopathological findings of a case of severe, treatment-refractory anti-Mi-2-positive DM. Results: A 77-year-old woman developed anti-Mi-2 DM with severe diffuse muscle weakness associated with abundant mitochondrial abnormalities at muscle biopsy, beside the typical features of inflammatory myopathy. The patient was poorly responsive to multiple-line therapies and finally anti-JAK (anti-Janus activated kinase) was administered, leading to partial clinical improvement. Discussion: Given the usual satisfactory treatment response and favorable outcome of anti-Mi-2 DM, we suppose that mitochondrial dysfunction on muscle biopsy could represent a marker of disease severity in DM, predicting a worse response to treatment and a poor clinical outcome. JAK-inhibitors could represent a good treatment option in refractory anti-Mi-2 DM with mitochondrial abnormalities. [ABSTRACT FROM AUTHOR]
Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Prominent mitochondrial pathology in a case of refractory dermatomyositis: coincidence or concause?
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  Data: <searchLink fieldCode="AR" term="%22Lauletta%2C+Antonio%22">Lauletta, Antonio</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22De+Carolis%2C+Lanfranco%22">De Carolis, Lanfranco</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Teresi%2C+Valentina%22">Teresi, Valentina</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fionda%2C+Laura%22">Fionda, Laura</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Leonardi%2C+Luca%22">Leonardi, Luca</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ceccanti%2C+Marco%22">Ceccanti, Marco</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Costanzo%2C+Rocco%22">Costanzo, Rocco</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rossini%2C+Elena%22">Rossini, Elena</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tufano%2C+Laura%22">Tufano, Laura</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Merlonghi%2C+Gioia%22">Merlonghi, Gioia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Morino%2C+Stefania%22">Morino, Stefania</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Garibaldi%2C+Matteo%22">Garibaldi, Matteo</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. Dec2023, Vol. 44 Issue 12, p4525-4529. 5p.
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  Data: <searchLink fieldCode="DE" term="%22Dermatomyositis%22">Dermatomyositis</searchLink><br /><searchLink fieldCode="DE" term="%22Inclusion+body+myositis%22">Inclusion body myositis</searchLink><br /><searchLink fieldCode="DE" term="%22Polymyositis%22">Polymyositis</searchLink><br /><searchLink fieldCode="DE" term="%22Mitochondrial+pathology%22">Mitochondrial pathology</searchLink><br /><searchLink fieldCode="DE" term="%22Muscle+weakness%22">Muscle weakness</searchLink><br /><searchLink fieldCode="DE" term="%22Coincidence%22">Coincidence</searchLink><br /><searchLink fieldCode="DE" term="%22Patient-professional+relations%22">Patient-professional relations</searchLink>
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  Label: Abstract
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  Data: Introduction: Mitochondrial alterations are a common finding in muscle biopsy of sporadic inclusion body myositis (s-IBM) and polymyositis with mitochondrial pathology (PM-Mito). Both disorders generally have poor treatment response. Nevertheless, mitochondrial myopathology has been rarely reported in dermatomyositis (DM) outside areas of perifascicular atrophy and a relationship with therapeutic outcome is not established. Methods: We report on clinical, immunological, radiological, and myopathological findings of a case of severe, treatment-refractory anti-Mi-2-positive DM. Results: A 77-year-old woman developed anti-Mi-2 DM with severe diffuse muscle weakness associated with abundant mitochondrial abnormalities at muscle biopsy, beside the typical features of inflammatory myopathy. The patient was poorly responsive to multiple-line therapies and finally anti-JAK (anti-Janus activated kinase) was administered, leading to partial clinical improvement. Discussion: Given the usual satisfactory treatment response and favorable outcome of anti-Mi-2 DM, we suppose that mitochondrial dysfunction on muscle biopsy could represent a marker of disease severity in DM, predicting a worse response to treatment and a poor clinical outcome. JAK-inhibitors could represent a good treatment option in refractory anti-Mi-2 DM with mitochondrial abnormalities. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s10072-023-07035-w
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        StartPage: 4525
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      – SubjectFull: Dermatomyositis
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