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Effects of HSYA on serum and brain cholesterol levels in AD rats based on quantitative proteomics.

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Title: Effects of HSYA on serum and brain cholesterol levels in AD rats based on quantitative proteomics.
Authors: Wang, Chunhui (AUTHOR), Hou, Jiawei (AUTHOR), Zhang, Mengyu (AUTHOR), Zheng, Yanjie (AUTHOR), Ye, Hongxia (AUTHOR), Qi, Yanqiang (AUTHOR), Guo, Li (AUTHOR), Hu, Yanli (AUTHOR)
Source: International Journal of Neuroscience. Dec2023, Vol. 133 Issue 12, p1411-1423. 13p.
Subjects: Blood cholesterol, Western immunoblotting, Hydroxycholesterols, Proteomics, Rats, Alzheimer's disease, Learning ability
Abstract: Backgroud: Hydroxysafflor yellow A (HSYA) has a certain improvement effect on Alzheimer's disease (AD) rats, but its specific mechanism is still unclear. The purpose of this study was to observe the regulatory effect of HSYA on learning and memory ability of AD rats induced by Aβ1-42. Materials and methods: Morris water maze test was used to evaluate the effect of HSYA on the learning and memory ability of AD model rats. To explore the effective targets and potential molecular mechanisms of HSYA in AD treatment based on quantitative proteomics. Results: Through the Morris water maze experiment, we found that after HSYA treatment, the learning ability of rats in the model group has been significantly improved. Quantitative proteomics results showed that among the 11 common differential proteins between the "model/sham operation" comparison group and the "HSYA treatment/model" comparison group, the cholesterol synthesis rate-limiting enzyme mevalonate decarboxylase (Mvd) Western Blot results are consistent with the results of quantitative proteomics analysis. We found that HSYA can inhibit the expression of BACE protein in hippocampus of AD rats and decrease the level of Aβ1-42. Besides, HSYA could also reduce cholesterol levels in serum and hippocampus. Conclusion: In summary, HSYA can effectively improve learning and memory disorders in AD rats, and exert neuroprotective effects by effectively controlling serum and brain cholesterol to down-regulate the expression of BACE and thus reduce the content of Aβ1-42. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: Effects of HSYA on serum and brain cholesterol levels in AD rats based on quantitative proteomics.
– Name: Author
  Label: Authors
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  Data: <searchLink fieldCode="AR" term="%22Wang%2C+Chunhui%22">Wang, Chunhui</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hou%2C+Jiawei%22">Hou, Jiawei</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Mengyu%22">Zhang, Mengyu</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zheng%2C+Yanjie%22">Zheng, Yanjie</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ye%2C+Hongxia%22">Ye, Hongxia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Qi%2C+Yanqiang%22">Qi, Yanqiang</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Guo%2C+Li%22">Guo, Li</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hu%2C+Yanli%22">Hu, Yanli</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Neuroscience%22">International Journal of Neuroscience</searchLink>. Dec2023, Vol. 133 Issue 12, p1411-1423. 13p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Blood+cholesterol%22">Blood cholesterol</searchLink><br /><searchLink fieldCode="DE" term="%22Western+immunoblotting%22">Western immunoblotting</searchLink><br /><searchLink fieldCode="DE" term="%22Hydroxycholesterols%22">Hydroxycholesterols</searchLink><br /><searchLink fieldCode="DE" term="%22Proteomics%22">Proteomics</searchLink><br /><searchLink fieldCode="DE" term="%22Rats%22">Rats</searchLink><br /><searchLink fieldCode="DE" term="%22Alzheimer's+disease%22">Alzheimer's disease</searchLink><br /><searchLink fieldCode="DE" term="%22Learning+ability%22">Learning ability</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Backgroud: Hydroxysafflor yellow A (HSYA) has a certain improvement effect on Alzheimer's disease (AD) rats, but its specific mechanism is still unclear. The purpose of this study was to observe the regulatory effect of HSYA on learning and memory ability of AD rats induced by Aβ1-42. Materials and methods: Morris water maze test was used to evaluate the effect of HSYA on the learning and memory ability of AD model rats. To explore the effective targets and potential molecular mechanisms of HSYA in AD treatment based on quantitative proteomics. Results: Through the Morris water maze experiment, we found that after HSYA treatment, the learning ability of rats in the model group has been significantly improved. Quantitative proteomics results showed that among the 11 common differential proteins between the "model/sham operation" comparison group and the "HSYA treatment/model" comparison group, the cholesterol synthesis rate-limiting enzyme mevalonate decarboxylase (Mvd) Western Blot results are consistent with the results of quantitative proteomics analysis. We found that HSYA can inhibit the expression of BACE protein in hippocampus of AD rats and decrease the level of Aβ1-42. Besides, HSYA could also reduce cholesterol levels in serum and hippocampus. Conclusion: In summary, HSYA can effectively improve learning and memory disorders in AD rats, and exert neuroprotective effects by effectively controlling serum and brain cholesterol to down-regulate the expression of BACE and thus reduce the content of Aβ1-42. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1080/00207454.2022.2082964
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        Text: English
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        PageCount: 13
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      – SubjectFull: Blood cholesterol
        Type: general
      – SubjectFull: Western immunoblotting
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      – SubjectFull: Hydroxycholesterols
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      – SubjectFull: Proteomics
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      – SubjectFull: Alzheimer's disease
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      – SubjectFull: Learning ability
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      – TitleFull: Effects of HSYA on serum and brain cholesterol levels in AD rats based on quantitative proteomics.
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              Text: Dec2023
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