Food cue reward salience does not explain Hyperphagia in adolescents with Prader-Willi syndrome.
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| Title: | Food cue reward salience does not explain Hyperphagia in adolescents with Prader-Willi syndrome. |
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| Authors: | Deweese, Menton M. (AUTHOR), Roof, Elizabeth (AUTHOR), Key, Alexandra P. (AUTHOR) |
| Source: | Developmental Neuropsychology. Oct2023, Vol. 48 Issue 7, p335-346. 12p. 2 Graphs. |
| Subjects: | Prader-Willi syndrome, Hyperphagia, Teenagers, Evoked potentials (Electrophysiology), Food of animal origin |
| Abstract: | Prader-Willi Syndrome (PWS) is characterized by hyperphagia, an extreme and persistent hunger that emerges in early childhood. We used event-related potentials (ERPs) to objectively investigate brain responses to low- and high-calorie foods, animals, and household objects in 20 satiated adolescents with PWS. Late Positive Potential (LPP) responses to food images did not differ from non-food images. Rather, we observed larger ERPs to high-calorie foods relative to animal images (p=.001) in an earlier time window. These responses correlated with greater severity of hyperphagia (p =.01). Thus, hyperphagia associated with PWS may be due to altered satiety regulation rather than increased motivational salience. [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | Prader-Willi Syndrome (PWS) is characterized by hyperphagia, an extreme and persistent hunger that emerges in early childhood. We used event-related potentials (ERPs) to objectively investigate brain responses to low- and high-calorie foods, animals, and household objects in 20 satiated adolescents with PWS. Late Positive Potential (LPP) responses to food images did not differ from non-food images. Rather, we observed larger ERPs to high-calorie foods relative to animal images (p=.001) in an earlier time window. These responses correlated with greater severity of hyperphagia (p =.01). Thus, hyperphagia associated with PWS may be due to altered satiety regulation rather than increased motivational salience. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 87565641 |
| DOI: | 10.1080/87565641.2023.2276950 |
