Sensitivity of memory subtests and learning slopes from the ADAS-Cog to distinguish along the continuum of the NIA-AA Research Framework for Alzheimer's Disease.
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| Title: | Sensitivity of memory subtests and learning slopes from the ADAS-Cog to distinguish along the continuum of the NIA-AA Research Framework for Alzheimer's Disease. |
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| Authors: | Hammers, Dustin B (AUTHOR), Kostadinova, Ralitsa V (AUTHOR), Spencer, Robert J (AUTHOR), Ikanga, Jean N (AUTHOR), Unverzagt, Frederick W (AUTHOR), Risacher, Shannon L (AUTHOR), Apostolova, Liana G (AUTHOR) |
| Source: | Aging, Neuropsychology & Cognition. 2023, Vol. 30 Issue 6, p866-884. 19p. |
| Subjects: | Alzheimer's disease, Wechsler Adult Intelligence Scale, Short-term memory, Memory, Learning |
| Abstract: | Despite extensive use of the Alzheimer's Disease (AD) Assessment Scale – Cognitive Subscale (ADAS-Cog) in AD research, exploration of memory subtests or process scores from the measure has been limited. The current study sought to establish validity for the ADAS-Cog Word Recall Immediate and Delayed Memory subtests and learning slope scores by showing that they are sensitive to AD biomarker status. Word Recall subtest and learning slope scores were calculated for 441 participants from the Alzheimer's Disease Neuroimaging Initiative (aged 55 to 90). All participants were categorized using the NIA-AA Research Framework – based on PET-imaging of β-amyloid (A) and tau (T) deposition – as Normal AD Biomarkers (A-T-), Alzheimer's Pathologic Change (A + T-), or Alzheimer's disease (A + T+). Memory subtest and learning slope performances were compared between biomarker status groups, and with regard to how well they discriminated samples with (A + T+) and without (A-T-) biomarkers. Lower Word Recall memory subtest scores – and scores for a particular learning slope calculation, the Learning Ratio – were observed for the AD (A + T+) group than the other biomarker groups. Memory subtest and Learning Ratio scores further displayed fair to good receiver operator characteristics when differentiating those with and without AD biomarkers. When comparing across learning slopes, the Learning Ratio metric consistently outperformed others. ADAS-Cog memory subtests and the Learning Ratio score are sensitive to AD biomarker status along the continuum of the NIA-AA Research Framework, and the results offer criterion validity for use of these subtests and process scores as unique markers of memory capacity. [ABSTRACT FROM AUTHOR] |
| Copyright of Aging, Neuropsychology & Cognition is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 173858826 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Sensitivity of memory subtests and learning slopes from the ADAS-Cog to distinguish along the continuum of the NIA-AA Research Framework for Alzheimer's Disease. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Hammers%2C+Dustin+B%22">Hammers, Dustin B</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kostadinova%2C+Ralitsa+V%22">Kostadinova, Ralitsa V</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Spencer%2C+Robert+J%22">Spencer, Robert J</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ikanga%2C+Jean+N%22">Ikanga, Jean N</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Unverzagt%2C+Frederick+W%22">Unverzagt, Frederick W</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Risacher%2C+Shannon+L%22">Risacher, Shannon L</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Apostolova%2C+Liana+G%22">Apostolova, Liana G</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Aging%2C+Neuropsychology+%26+Cognition%22">Aging, Neuropsychology & Cognition</searchLink>. 2023, Vol. 30 Issue 6, p866-884. 19p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Alzheimer's+disease%22">Alzheimer's disease</searchLink><br /><searchLink fieldCode="DE" term="%22Wechsler+Adult+Intelligence+Scale%22">Wechsler Adult Intelligence Scale</searchLink><br /><searchLink fieldCode="DE" term="%22Short-term+memory%22">Short-term memory</searchLink><br /><searchLink fieldCode="DE" term="%22Memory%22">Memory</searchLink><br /><searchLink fieldCode="DE" term="%22Learning%22">Learning</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Despite extensive use of the Alzheimer's Disease (AD) Assessment Scale – Cognitive Subscale (ADAS-Cog) in AD research, exploration of memory subtests or process scores from the measure has been limited. The current study sought to establish validity for the ADAS-Cog Word Recall Immediate and Delayed Memory subtests and learning slope scores by showing that they are sensitive to AD biomarker status. Word Recall subtest and learning slope scores were calculated for 441 participants from the Alzheimer's Disease Neuroimaging Initiative (aged 55 to 90). All participants were categorized using the NIA-AA Research Framework – based on PET-imaging of β-amyloid (A) and tau (T) deposition – as Normal AD Biomarkers (A-T-), Alzheimer's Pathologic Change (A + T-), or Alzheimer's disease (A + T+). Memory subtest and learning slope performances were compared between biomarker status groups, and with regard to how well they discriminated samples with (A + T+) and without (A-T-) biomarkers. Lower Word Recall memory subtest scores – and scores for a particular learning slope calculation, the Learning Ratio – were observed for the AD (A + T+) group than the other biomarker groups. Memory subtest and Learning Ratio scores further displayed fair to good receiver operator characteristics when differentiating those with and without AD biomarkers. When comparing across learning slopes, the Learning Ratio metric consistently outperformed others. ADAS-Cog memory subtests and the Learning Ratio score are sensitive to AD biomarker status along the continuum of the NIA-AA Research Framework, and the results offer criterion validity for use of these subtests and process scores as unique markers of memory capacity. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Aging, Neuropsychology & Cognition is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1080/13825585.2022.2120957 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 19 StartPage: 866 Subjects: – SubjectFull: Alzheimer's disease Type: general – SubjectFull: Wechsler Adult Intelligence Scale Type: general – SubjectFull: Short-term memory Type: general – SubjectFull: Memory Type: general – SubjectFull: Learning Type: general Titles: – TitleFull: Sensitivity of memory subtests and learning slopes from the ADAS-Cog to distinguish along the continuum of the NIA-AA Research Framework for Alzheimer's Disease. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Hammers, Dustin B – PersonEntity: Name: NameFull: Kostadinova, Ralitsa V – PersonEntity: Name: NameFull: Spencer, Robert J – PersonEntity: Name: NameFull: Ikanga, Jean N – PersonEntity: Name: NameFull: Unverzagt, Frederick W – PersonEntity: Name: NameFull: Risacher, Shannon L – PersonEntity: Name: NameFull: Apostolova, Liana G IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 11 Text: 2023 Type: published Y: 2023 Identifiers: – Type: issn-print Value: 13825585 Numbering: – Type: volume Value: 30 – Type: issue Value: 6 Titles: – TitleFull: Aging, Neuropsychology & Cognition Type: main |
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