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Divergent molecular networks program functionally distinct CD8+ skin-resident memory T cells.

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Title: Divergent molecular networks program functionally distinct CD8+ skin-resident memory T cells.
Authors: Park, Simone L., Christo, Susan N., Wells, Alexandria C., Gandolfo, Luke C., Zaid, Ali, Alexandre, Yannick O., Burn, Thomas N., Schröder, Jan, Collins, Nicholas, Seong-Ji Han, Guillaume, Stéphane M., Evrard, Maximilien, Castellucci, Clara, Davies, Brooke, Osman, Maleika, Obers, Andreas, McDonald, Keely M., Huimeng Wang, Mueller, Scott N., Kannourakis, George
Source: Science (pre-March 2025). 12/1/2023, Vol. 382 Issue 6674, p1073-1079. 7p. 4 Diagrams.
Subjects: Immunologic memory, CD8 antigen, Cell determination, T cells, Immune response, Interleukin-17
Abstract: Skin-resident CD8+ T cells include distinct interferon-γ–producing [tissue-resident memory T type 1 (TRM1)] and interleukin-17 (IL-17)–producing (TRM17) subsets that differentially contribute to immune responses. However, whether these populations use common mechanisms to establish tissue residence is unknown. In this work, we show that TRM1 and TRM17 cells navigate divergent trajectories to acquire tissue residency in the skin. TRM1 cells depend on a T-bet–Hobit–IL-15 axis, whereas TRM17 cells develop independently of these factors. Instead, c-Maf commands a tissue-resident program in TRM17 cells parallel to that induced by Hobit in TRM1 cells, with an ICOS–c-Maf–IL-7 axis pivotal to TRM17 cell commitment. Accordingly, by targeting this pathway, skin TRM17 cells can be ablated without compromising their TRM1 counterparts. Thus, skin-resident T cells rely on distinct molecular circuitries, which can be exploited to strategically modulate local immunity. [ABSTRACT FROM AUTHOR]
Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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PubTypeId: academicJournal
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  Data: Divergent molecular networks program functionally distinct CD8<superscript>+</superscript> skin-resident memory T cells.
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  Data: <searchLink fieldCode="AR" term="%22Park%2C+Simone+L%2E%22">Park, Simone L.</searchLink><br /><searchLink fieldCode="AR" term="%22Christo%2C+Susan+N%2E%22">Christo, Susan N.</searchLink><br /><searchLink fieldCode="AR" term="%22Wells%2C+Alexandria+C%2E%22">Wells, Alexandria C.</searchLink><br /><searchLink fieldCode="AR" term="%22Gandolfo%2C+Luke+C%2E%22">Gandolfo, Luke C.</searchLink><br /><searchLink fieldCode="AR" term="%22Zaid%2C+Ali%22">Zaid, Ali</searchLink><br /><searchLink fieldCode="AR" term="%22Alexandre%2C+Yannick+O%2E%22">Alexandre, Yannick O.</searchLink><br /><searchLink fieldCode="AR" term="%22Burn%2C+Thomas+N%2E%22">Burn, Thomas N.</searchLink><br /><searchLink fieldCode="AR" term="%22Schröder%2C+Jan%22">Schröder, Jan</searchLink><br /><searchLink fieldCode="AR" term="%22Collins%2C+Nicholas%22">Collins, Nicholas</searchLink><br /><searchLink fieldCode="AR" term="%22Seong-Ji+Han%22">Seong-Ji Han</searchLink><br /><searchLink fieldCode="AR" term="%22Guillaume%2C+Stéphane+M%2E%22">Guillaume, Stéphane M.</searchLink><br /><searchLink fieldCode="AR" term="%22Evrard%2C+Maximilien%22">Evrard, Maximilien</searchLink><br /><searchLink fieldCode="AR" term="%22Castellucci%2C+Clara%22">Castellucci, Clara</searchLink><br /><searchLink fieldCode="AR" term="%22Davies%2C+Brooke%22">Davies, Brooke</searchLink><br /><searchLink fieldCode="AR" term="%22Osman%2C+Maleika%22">Osman, Maleika</searchLink><br /><searchLink fieldCode="AR" term="%22Obers%2C+Andreas%22">Obers, Andreas</searchLink><br /><searchLink fieldCode="AR" term="%22McDonald%2C+Keely+M%2E%22">McDonald, Keely M.</searchLink><br /><searchLink fieldCode="AR" term="%22Huimeng+Wang%22">Huimeng Wang</searchLink><br /><searchLink fieldCode="AR" term="%22Mueller%2C+Scott+N%2E%22">Mueller, Scott N.</searchLink><br /><searchLink fieldCode="AR" term="%22Kannourakis%2C+George%22">Kannourakis, George</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 12/1/2023, Vol. 382 Issue 6674, p1073-1079. 7p. 4 Diagrams.
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  Data: <searchLink fieldCode="DE" term="%22Immunologic+memory%22">Immunologic memory</searchLink><br /><searchLink fieldCode="DE" term="%22CD8+antigen%22">CD8 antigen</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+determination%22">Cell determination</searchLink><br /><searchLink fieldCode="DE" term="%22T+cells%22">T cells</searchLink><br /><searchLink fieldCode="DE" term="%22Immune+response%22">Immune response</searchLink><br /><searchLink fieldCode="DE" term="%22Interleukin-17%22">Interleukin-17</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Skin-resident CD8+ T cells include distinct interferon-γ–producing [tissue-resident memory T type 1 (TRM1)] and interleukin-17 (IL-17)–producing (TRM17) subsets that differentially contribute to immune responses. However, whether these populations use common mechanisms to establish tissue residence is unknown. In this work, we show that TRM1 and TRM17 cells navigate divergent trajectories to acquire tissue residency in the skin. TRM1 cells depend on a T-bet–Hobit–IL-15 axis, whereas TRM17 cells develop independently of these factors. Instead, c-Maf commands a tissue-resident program in TRM17 cells parallel to that induced by Hobit in TRM1 cells, with an ICOS–c-Maf–IL-7 axis pivotal to TRM17 cell commitment. Accordingly, by targeting this pathway, skin TRM17 cells can be ablated without compromising their TRM1 counterparts. Thus, skin-resident T cells rely on distinct molecular circuitries, which can be exploited to strategically modulate local immunity. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1126/science.adi8885
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        Text: English
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        Type: general
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      – SubjectFull: Cell determination
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      – SubjectFull: Interleukin-17
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