Obesity in pregnancy—Long‐term effects on offspring hypothalamic‐pituitary‐adrenal axis and associations with placental cortisol metabolism: A systematic review.
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| Title: | Obesity in pregnancy—Long‐term effects on offspring hypothalamic‐pituitary‐adrenal axis and associations with placental cortisol metabolism: A systematic review. |
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| Authors: | Volqvartz, Tabia (AUTHOR), Andersen, Helena Hørdum Breum (AUTHOR), Pedersen, Lars Henning (AUTHOR), Larsen, Agnete (AUTHOR) |
| Source: | European Journal of Neuroscience. Dec2023, Vol. 58 Issue 11, p4393-4422. 30p. |
| Subjects: | Hypothalamic-pituitary-adrenal axis, Cord blood, Placenta, Hydrocortisone, Overweight children |
| Abstract: | Obesity, affecting one in three pregnant women worldwide, is not only a major obstetric risk factor. The resulting low‐grade inflammation may have a long‐term impact on the offspring's HPA axis through dysregulation of maternal, placental and fetal corticosteroid metabolism, and children born of obese mothers have increased risk of diabetes and cardiovascular disease. The long‐term effects of maternal obesity on offspring neurodevelopment are, however, undetermined and could depend on the specific effects on placental and fetal cortisol metabolism. This systematic review evaluates how maternal obesity affects placental cortisol metabolism and the offspring's HPA axis. Pubmed, Embase and Scopus were searched for original studies on maternal BMI, obesity, and cortisol metabolism and transfer. Fifteen studies were included after the screening of 4556 identified records. Studies were small with heterogeneous exposures and outcomes. Two studies found that maternal obesity reduced placental HSD11β2 activity. In one study, umbilical cord blood cortisol levels were affected by maternal BMI. In three studies, an altered cortisol response was consistently seen among offspring in childhood (n = 2) or adulthood (n = 1). Maternal BMI was not associated with placental HSD11β1 or HSD11β2 mRNA expression, or placental HSD11β2 methylation. In conclusion, high maternal BMI is associated with reduced placental HSD11β2 activity and a dampened cortisol level among offspring, but the data is sparse. Further investigations are needed to clarify whether the HPA axis is affected by prenatal factors including maternal obesity and investigate if adverse effects can be ameliorated by optimising the intrauterine environment. [ABSTRACT FROM AUTHOR] |
| Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 173988680 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Obesity in pregnancy—Long‐term effects on offspring hypothalamic‐pituitary‐adrenal axis and associations with placental cortisol metabolism: A systematic review. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Volqvartz%2C+Tabia%22">Volqvartz, Tabia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Andersen%2C+Helena+Hørdum+Breum%22">Andersen, Helena Hørdum Breum</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pedersen%2C+Lars+Henning%22">Pedersen, Lars Henning</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Larsen%2C+Agnete%22">Larsen, Agnete</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Dec2023, Vol. 58 Issue 11, p4393-4422. 30p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Hypothalamic-pituitary-adrenal+axis%22">Hypothalamic-pituitary-adrenal axis</searchLink><br /><searchLink fieldCode="DE" term="%22Cord+blood%22">Cord blood</searchLink><br /><searchLink fieldCode="DE" term="%22Placenta%22">Placenta</searchLink><br /><searchLink fieldCode="DE" term="%22Hydrocortisone%22">Hydrocortisone</searchLink><br /><searchLink fieldCode="DE" term="%22Overweight+children%22">Overweight children</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Obesity, affecting one in three pregnant women worldwide, is not only a major obstetric risk factor. The resulting low‐grade inflammation may have a long‐term impact on the offspring's HPA axis through dysregulation of maternal, placental and fetal corticosteroid metabolism, and children born of obese mothers have increased risk of diabetes and cardiovascular disease. The long‐term effects of maternal obesity on offspring neurodevelopment are, however, undetermined and could depend on the specific effects on placental and fetal cortisol metabolism. This systematic review evaluates how maternal obesity affects placental cortisol metabolism and the offspring's HPA axis. Pubmed, Embase and Scopus were searched for original studies on maternal BMI, obesity, and cortisol metabolism and transfer. Fifteen studies were included after the screening of 4556 identified records. Studies were small with heterogeneous exposures and outcomes. Two studies found that maternal obesity reduced placental HSD11β2 activity. In one study, umbilical cord blood cortisol levels were affected by maternal BMI. In three studies, an altered cortisol response was consistently seen among offspring in childhood (n = 2) or adulthood (n = 1). Maternal BMI was not associated with placental HSD11β1 or HSD11β2 mRNA expression, or placental HSD11β2 methylation. In conclusion, high maternal BMI is associated with reduced placental HSD11β2 activity and a dampened cortisol level among offspring, but the data is sparse. Further investigations are needed to clarify whether the HPA axis is affected by prenatal factors including maternal obesity and investigate if adverse effects can be ameliorated by optimising the intrauterine environment. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=173988680 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/ejn.16184 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 30 StartPage: 4393 Subjects: – SubjectFull: Hypothalamic-pituitary-adrenal axis Type: general – SubjectFull: Cord blood Type: general – SubjectFull: Placenta Type: general – SubjectFull: Hydrocortisone Type: general – SubjectFull: Overweight children Type: general Titles: – TitleFull: Obesity in pregnancy—Long‐term effects on offspring hypothalamic‐pituitary‐adrenal axis and associations with placental cortisol metabolism: A systematic review. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Volqvartz, Tabia – PersonEntity: Name: NameFull: Andersen, Helena Hørdum Breum – PersonEntity: Name: NameFull: Pedersen, Lars Henning – PersonEntity: Name: NameFull: Larsen, Agnete IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 12 Text: Dec2023 Type: published Y: 2023 Identifiers: – Type: issn-print Value: 0953816X Numbering: – Type: volume Value: 58 – Type: issue Value: 11 Titles: – TitleFull: European Journal of Neuroscience Type: main |
| ResultId | 1 |
