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Inflammatory Response and Glia Activation in Developing Rat Hippocampus after Status Epilepticus.

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Title: Inflammatory Response and Glia Activation in Developing Rat Hippocampus after Status Epilepticus.
Authors: Ravizza, Teresa, Rizzi, Massimo, Perego, Carlo, Richichi, Cristina, Velísk&#xU+01D2;vá, Jana, Moshé, Solomon L., de Simoni, M. Grazia, Vezzani, Annamaria
Source: Epilepsia (Series 4). Jul2005 Supplement 5, Vol. 46, p113-117. 5p.
Subjects: Microglia, Astrocytes, Cytokines, Neuroglia, Tumor necrosis factors, Amino acids
Abstract: Purpose: We investigated the activation of microglia and astrocytes, induction of cytokines, and hippocampal neuronal damage, 4 and 24 h after kainic acid–induced status epilepticus (SE) in postnatal day (PN) 9, 15, and 21 rats. Methods: Limbic seizures were induced by systemic injection of kainic acid. Glia activation and neuronal cell loss were studied by using immunocytochemistry and Western blot. Cytokine expression was analyzed by reverse transcriptase–polymerase chain reaction (RT-PCR) followed by Southern blot quantification. Results: After SE onset, hippocampal glia activation, cytokine expression, and neuronal damage are all age-dependent phenomena. In the hippocampus, neuronal injury occurs only when cytokines are induced in glia, and cytokine synthesis precedes the appearance of degenerating neurons. Neuronal injury is more pronounced when interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) are produced in addition to IL-1β. Conclusions: This study shows that cytokine induction in rat brain after sustained seizures is age dependent, and it is associated with the appearance of cell injury. [ABSTRACT FROM AUTHOR]
Copyright of Epilepsia (Series 4) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Inflammatory Response and Glia Activation in Developing Rat Hippocampus after Status Epilepticus.
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  Data: <searchLink fieldCode="AR" term="%22Ravizza%2C+Teresa%22">Ravizza, Teresa</searchLink><br /><searchLink fieldCode="AR" term="%22Rizzi%2C+Massimo%22">Rizzi, Massimo</searchLink><br /><searchLink fieldCode="AR" term="%22Perego%2C+Carlo%22">Perego, Carlo</searchLink><br /><searchLink fieldCode="AR" term="%22Richichi%2C+Cristina%22">Richichi, Cristina</searchLink><br /><searchLink fieldCode="AR" term="%22Velísk%26#xU%2B01D2%3Bvá%2C+Jana%22">Velísk&#xU+01D2;vá, Jana</searchLink><br /><searchLink fieldCode="AR" term="%22Moshé%2C+Solomon+L%2E%22">Moshé, Solomon L.</searchLink><br /><searchLink fieldCode="AR" term="%22de+Simoni%2C+M%2E+Grazia%22">de Simoni, M. Grazia</searchLink><br /><searchLink fieldCode="AR" term="%22Vezzani%2C+Annamaria%22">Vezzani, Annamaria</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Epilepsia+%28Series+4%29%22">Epilepsia (Series 4)</searchLink>. Jul2005 Supplement 5, Vol. 46, p113-117. 5p.
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  Data: <searchLink fieldCode="DE" term="%22Microglia%22">Microglia</searchLink><br /><searchLink fieldCode="DE" term="%22Astrocytes%22">Astrocytes</searchLink><br /><searchLink fieldCode="DE" term="%22Cytokines%22">Cytokines</searchLink><br /><searchLink fieldCode="DE" term="%22Neuroglia%22">Neuroglia</searchLink><br /><searchLink fieldCode="DE" term="%22Tumor+necrosis+factors%22">Tumor necrosis factors</searchLink><br /><searchLink fieldCode="DE" term="%22Amino+acids%22">Amino acids</searchLink>
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  Data: Purpose: We investigated the activation of microglia and astrocytes, induction of cytokines, and hippocampal neuronal damage, 4 and 24 h after kainic acid–induced status epilepticus (SE) in postnatal day (PN) 9, 15, and 21 rats. Methods: Limbic seizures were induced by systemic injection of kainic acid. Glia activation and neuronal cell loss were studied by using immunocytochemistry and Western blot. Cytokine expression was analyzed by reverse transcriptase–polymerase chain reaction (RT-PCR) followed by Southern blot quantification. Results: After SE onset, hippocampal glia activation, cytokine expression, and neuronal damage are all age-dependent phenomena. In the hippocampus, neuronal injury occurs only when cytokines are induced in glia, and cytokine synthesis precedes the appearance of degenerating neurons. Neuronal injury is more pronounced when interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) are produced in addition to IL-1β. Conclusions: This study shows that cytokine induction in rat brain after sustained seizures is age dependent, and it is associated with the appearance of cell injury. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Epilepsia (Series 4) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1111/j.1528-1167.2005.01006.x
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      – Code: eng
        Text: English
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      – SubjectFull: Cytokines
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      – SubjectFull: Amino acids
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              Text: Jul2005 Supplement 5
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              Y: 2005
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