Association of the dopamine transporter (DAT1) 10/10-repeat genotype with ADHD symptoms and response inhibition in a general population sample.
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| Title: | Association of the dopamine transporter (DAT1) 10/10-repeat genotype with ADHD symptoms and response inhibition in a general population sample. |
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| Authors: | Cornish, K. M., Manly, T., Savage, R., Swanson, J., Morisano, D., Butler, N., Grant, C., Cross, G., Bentley, L., Hollis, C. P. |
| Source: | Molecular Psychiatry. Jul2005, Vol. 10 Issue 7, p686-698. 13p. |
| Subjects: | Attention-deficit hyperactivity disorder, Dopamine, Genes, Neuropsychology, Short-term memory, Symptoms |
| Abstract: | Association between attention-deficit hyperactivity disorder (ADHD) and the 10-repeat allele of the dopamine transporter gene (DAT1) has been reported in independent clinical samples using a categorical clinical definition of ADHD. The present study adopts a quantitative trait loci (QTL) approach to examine the association between DAT1 and a continuous measure of ADHD behaviours in a general-population sample, as well as to explore whether there is an independent association between DAT1 and performance on neuropsychological tests of attention, response inhibition, and working memory. From an epidemiological sample of 872 boys aged 6–11 years, we recruited 58 boys scoring above the 90th percentile for teacher reported ADHD symptoms (SWAN ADHD scale) and 68 boys scoring below 10th percentile for genotyping and neuropsychological testing. A significant association was found between the DAT1 homozygous 10/10-repeat genotype and high-scoring boys (χ2square=4.6, P<0.03; odds ratio=2.4, 95% CI 1.1–5.0). Using hierarchical linear regression, a significant independent association was found between the DAT1 10/10-repeat genotype and measures of selective attention and response inhibition after adjusting for age, IQ, and ADHD symptoms. There was no association between DAT1 and any component of working memory. Furthermore, performance on tasks of selective attention although associated with DAT1 was not associated with SWAN ADHD high scores after controlling for age and IQ. In contrast, impairment on tasks that tapped sustained attention and the central executive component of working memory were found in high-scoring boys after adjusting for age and IQ. The results suggest that DAT1 is a QTL for continuously distributed ADHD behaviours in the general population and the cognitive endophenotype of response inhibition.Molecular Psychiatry (2005) 10, 686–698. doi:10.1038/sj.mp.4001641 Published online 5 April 2005 [ABSTRACT FROM AUTHOR] |
| Copyright of Molecular Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 17419124 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Association of the dopamine transporter (DAT1) 10/10-repeat genotype with ADHD symptoms and response inhibition in a general population sample. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Cornish%2C+K%2E+M%2E%22">Cornish, K. M.</searchLink><br /><searchLink fieldCode="AR" term="%22Manly%2C+T%2E%22">Manly, T.</searchLink><br /><searchLink fieldCode="AR" term="%22Savage%2C+R%2E%22">Savage, R.</searchLink><br /><searchLink fieldCode="AR" term="%22Swanson%2C+J%2E%22">Swanson, J.</searchLink><br /><searchLink fieldCode="AR" term="%22Morisano%2C+D%2E%22">Morisano, D.</searchLink><br /><searchLink fieldCode="AR" term="%22Butler%2C+N%2E%22">Butler, N.</searchLink><br /><searchLink fieldCode="AR" term="%22Grant%2C+C%2E%22">Grant, C.</searchLink><br /><searchLink fieldCode="AR" term="%22Cross%2C+G%2E%22">Cross, G.</searchLink><br /><searchLink fieldCode="AR" term="%22Bentley%2C+L%2E%22">Bentley, L.</searchLink><br /><searchLink fieldCode="AR" term="%22Hollis%2C+C%2E+P%2E%22">Hollis, C. P.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Molecular+Psychiatry%22">Molecular Psychiatry</searchLink>. Jul2005, Vol. 10 Issue 7, p686-698. 13p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Attention-deficit+hyperactivity+disorder%22">Attention-deficit hyperactivity disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Dopamine%22">Dopamine</searchLink><br /><searchLink fieldCode="DE" term="%22Genes%22">Genes</searchLink><br /><searchLink fieldCode="DE" term="%22Neuropsychology%22">Neuropsychology</searchLink><br /><searchLink fieldCode="DE" term="%22Short-term+memory%22">Short-term memory</searchLink><br /><searchLink fieldCode="DE" term="%22Symptoms%22">Symptoms</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Association between attention-deficit hyperactivity disorder (ADHD) and the 10-repeat allele of the dopamine transporter gene (DAT1) has been reported in independent clinical samples using a categorical clinical definition of ADHD. The present study adopts a quantitative trait loci (QTL) approach to examine the association between DAT1 and a continuous measure of ADHD behaviours in a general-population sample, as well as to explore whether there is an independent association between DAT1 and performance on neuropsychological tests of attention, response inhibition, and working memory. From an epidemiological sample of 872 boys aged 6–11 years, we recruited 58 boys scoring above the 90th percentile for teacher reported ADHD symptoms (SWAN ADHD scale) and 68 boys scoring below 10th percentile for genotyping and neuropsychological testing. A significant association was found between the DAT1 homozygous 10/10-repeat genotype and high-scoring boys (χ2square=4.6, P<0.03; odds ratio=2.4, 95% CI 1.1–5.0). Using hierarchical linear regression, a significant independent association was found between the DAT1 10/10-repeat genotype and measures of selective attention and response inhibition after adjusting for age, IQ, and ADHD symptoms. There was no association between DAT1 and any component of working memory. Furthermore, performance on tasks of selective attention although associated with DAT1 was not associated with SWAN ADHD high scores after controlling for age and IQ. In contrast, impairment on tasks that tapped sustained attention and the central executive component of working memory were found in high-scoring boys after adjusting for age and IQ. The results suggest that DAT1 is a QTL for continuously distributed ADHD behaviours in the general population and the cognitive endophenotype of response inhibition.Molecular Psychiatry (2005) 10, 686–698. doi:10.1038/sj.mp.4001641 Published online 5 April 2005 [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Molecular Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/sj.mp.4001641 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 13 StartPage: 686 Subjects: – SubjectFull: Attention-deficit hyperactivity disorder Type: general – SubjectFull: Dopamine Type: general – SubjectFull: Genes Type: general – SubjectFull: Neuropsychology Type: general – SubjectFull: Short-term memory Type: general – SubjectFull: Symptoms Type: general Titles: – TitleFull: Association of the dopamine transporter (DAT1) 10/10-repeat genotype with ADHD symptoms and response inhibition in a general population sample. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Cornish, K. M. – PersonEntity: Name: NameFull: Manly, T. – PersonEntity: Name: NameFull: Savage, R. – PersonEntity: Name: NameFull: Swanson, J. – PersonEntity: Name: NameFull: Morisano, D. – PersonEntity: Name: NameFull: Butler, N. – PersonEntity: Name: NameFull: Grant, C. – PersonEntity: Name: NameFull: Cross, G. – PersonEntity: Name: NameFull: Bentley, L. – PersonEntity: Name: NameFull: Hollis, C. P. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: Jul2005 Type: published Y: 2005 Identifiers: – Type: issn-print Value: 13594184 Numbering: – Type: volume Value: 10 – Type: issue Value: 7 Titles: – TitleFull: Molecular Psychiatry Type: main |
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