View in EDS HTML Full Text PDF Full Text

DNA methylation at birth and lateral ventricular volume in childhood: a neuroimaging epigenetics study.

Saved in:
Bibliographic Details
Title: DNA methylation at birth and lateral ventricular volume in childhood: a neuroimaging epigenetics study.
Authors: Luo, Mannan (AUTHOR), Walton, Esther (AUTHOR), Neumann, Alexander (AUTHOR), Thio, Chris H. L. (AUTHOR), Felix, Janine F. (AUTHOR), van IJzendoorn, Marinus H. (AUTHOR), Pappa, Irene (AUTHOR), Cecil, Charlotte A. M. (AUTHOR)
Source: Journal of Child Psychology & Psychiatry. Jan2024, Vol. 65 Issue 1, p77-90. 14p.
Subjects: Biomarkers, Schizophrenia, DNA methylation, Heart ventricles, Genome-wide association studies, Peripheral circulation, Neural development, Cord blood, Genes, Descriptive statistics, Heart physiology, Epigenomics, Neuroradiology
Abstract: Background: Lateral ventricular volume (LVV) enlargement has been repeatedly linked to schizophrenia; yet, what biological factors shape LVV during early development remain unclear. DNA methylation (DNAm), an essential process for neurodevelopment that is altered in schizophrenia, is a key molecular system of interest. Methods: In this study, we conducted the first epigenome‐wide association study of neonatal DNAm in cord blood with LVV in childhood (measured using T1‐weighted brain scans at 10 years), based on data from a large population‐based birth cohort, the Generation R Study (N = 840). Employing both probe‐level and methylation profile score (MPS) approaches, we further examined whether epigenetic modifications identified at birth in cord blood are: (a) also observed cross‐sectionally in childhood using peripheral blood DNAm at age of 10 years (Generation R, N = 370) and (b) prospectively associated with LVV measured in young adulthood in an all‐male sample from the Avon Longitudinal Study of Parents and Children (ALSPAC, N = 114). Results: At birth, DNAm levels at four CpGs (annotated to potassium channel tetramerization domain containing 3, KCTD3; SHH signaling and ciliogenesis regulator, SDCCAG8; glutaredoxin, GLRX) prospectively associated with childhood LVV after genome‐wide correction; these genes have been implicated in brain development and psychiatric traits including schizophrenia. An MPS capturing a broader epigenetic profile of LVV – but not individual top hits – showed significant cross‐sectional associations with LVV in childhood in Generation R and prospectively associated with LVV in early adulthood within ALSPAC. Conclusions: This study finds suggestive evidence that DNAm at birth prospectively associates with LVV at different life stages, albeit with small effect sizes. The prediction of MPS on LVV in a childhood sample and an independent male adult sample further underscores the stability and reproducibility of DNAm as a potential marker for LVV. Future studies with larger samples and comparable time points across development are needed to further elucidate how DNAm associates with this clinically relevant brain structure and risk for neuropsychiatric disorders, and what factors explain the identified DNAm profile of LVV at birth. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Child Psychology & Psychiatry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 174271091
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: DNA methylation at birth and lateral ventricular volume in childhood: a neuroimaging epigenetics study.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Luo%2C+Mannan%22">Luo, Mannan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Walton%2C+Esther%22">Walton, Esther</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Neumann%2C+Alexander%22">Neumann, Alexander</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Thio%2C+Chris+H%2E+L%2E%22">Thio, Chris H. L.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Felix%2C+Janine+F%2E%22">Felix, Janine F.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22van+IJzendoorn%2C+Marinus+H%2E%22">van IJzendoorn, Marinus H.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pappa%2C+Irene%22">Pappa, Irene</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cecil%2C+Charlotte+A%2E+M%2E%22">Cecil, Charlotte A. M.</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Journal+of+Child+Psychology+%26+Psychiatry%22">Journal of Child Psychology & Psychiatry</searchLink>. Jan2024, Vol. 65 Issue 1, p77-90. 14p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Biomarkers%22">Biomarkers</searchLink><br /><searchLink fieldCode="DE" term="%22Schizophrenia%22">Schizophrenia</searchLink><br /><searchLink fieldCode="DE" term="%22DNA+methylation%22">DNA methylation</searchLink><br /><searchLink fieldCode="DE" term="%22Heart+ventricles%22">Heart ventricles</searchLink><br /><searchLink fieldCode="DE" term="%22Genome-wide+association+studies%22">Genome-wide association studies</searchLink><br /><searchLink fieldCode="DE" term="%22Peripheral+circulation%22">Peripheral circulation</searchLink><br /><searchLink fieldCode="DE" term="%22Neural+development%22">Neural development</searchLink><br /><searchLink fieldCode="DE" term="%22Cord+blood%22">Cord blood</searchLink><br /><searchLink fieldCode="DE" term="%22Genes%22">Genes</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Heart+physiology%22">Heart physiology</searchLink><br /><searchLink fieldCode="DE" term="%22Epigenomics%22">Epigenomics</searchLink><br /><searchLink fieldCode="DE" term="%22Neuroradiology%22">Neuroradiology</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: Lateral ventricular volume (LVV) enlargement has been repeatedly linked to schizophrenia; yet, what biological factors shape LVV during early development remain unclear. DNA methylation (DNAm), an essential process for neurodevelopment that is altered in schizophrenia, is a key molecular system of interest. Methods: In this study, we conducted the first epigenome‐wide association study of neonatal DNAm in cord blood with LVV in childhood (measured using T1‐weighted brain scans at 10 years), based on data from a large population‐based birth cohort, the Generation R Study (N = 840). Employing both probe‐level and methylation profile score (MPS) approaches, we further examined whether epigenetic modifications identified at birth in cord blood are: (a) also observed cross‐sectionally in childhood using peripheral blood DNAm at age of 10 years (Generation R, N = 370) and (b) prospectively associated with LVV measured in young adulthood in an all‐male sample from the Avon Longitudinal Study of Parents and Children (ALSPAC, N = 114). Results: At birth, DNAm levels at four CpGs (annotated to potassium channel tetramerization domain containing 3, KCTD3; SHH signaling and ciliogenesis regulator, SDCCAG8; glutaredoxin, GLRX) prospectively associated with childhood LVV after genome‐wide correction; these genes have been implicated in brain development and psychiatric traits including schizophrenia. An MPS capturing a broader epigenetic profile of LVV – but not individual top hits – showed significant cross‐sectional associations with LVV in childhood in Generation R and prospectively associated with LVV in early adulthood within ALSPAC. Conclusions: This study finds suggestive evidence that DNAm at birth prospectively associates with LVV at different life stages, albeit with small effect sizes. The prediction of MPS on LVV in a childhood sample and an independent male adult sample further underscores the stability and reproducibility of DNAm as a potential marker for LVV. Future studies with larger samples and comparable time points across development are needed to further elucidate how DNAm associates with this clinically relevant brain structure and risk for neuropsychiatric disorders, and what factors explain the identified DNAm profile of LVV at birth. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Child Psychology & Psychiatry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=174271091
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/jcpp.13866
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 14
        StartPage: 77
    Subjects:
      – SubjectFull: Biomarkers
        Type: general
      – SubjectFull: Schizophrenia
        Type: general
      – SubjectFull: DNA methylation
        Type: general
      – SubjectFull: Heart ventricles
        Type: general
      – SubjectFull: Genome-wide association studies
        Type: general
      – SubjectFull: Peripheral circulation
        Type: general
      – SubjectFull: Neural development
        Type: general
      – SubjectFull: Cord blood
        Type: general
      – SubjectFull: Genes
        Type: general
      – SubjectFull: Descriptive statistics
        Type: general
      – SubjectFull: Heart physiology
        Type: general
      – SubjectFull: Epigenomics
        Type: general
      – SubjectFull: Neuroradiology
        Type: general
    Titles:
      – TitleFull: DNA methylation at birth and lateral ventricular volume in childhood: a neuroimaging epigenetics study.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Luo, Mannan
      – PersonEntity:
          Name:
            NameFull: Walton, Esther
      – PersonEntity:
          Name:
            NameFull: Neumann, Alexander
      – PersonEntity:
          Name:
            NameFull: Thio, Chris H. L.
      – PersonEntity:
          Name:
            NameFull: Felix, Janine F.
      – PersonEntity:
          Name:
            NameFull: van IJzendoorn, Marinus H.
      – PersonEntity:
          Name:
            NameFull: Pappa, Irene
      – PersonEntity:
          Name:
            NameFull: Cecil, Charlotte A. M.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 01
              Text: Jan2024
              Type: published
              Y: 2024
          Identifiers:
            – Type: issn-print
              Value: 00219630
          Numbering:
            – Type: volume
              Value: 65
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Journal of Child Psychology & Psychiatry
              Type: main
ResultId 1