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The association between varicella zoster virus and dementia: a systematic review and meta-analysis of observational studies.

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Title: The association between varicella zoster virus and dementia: a systematic review and meta-analysis of observational studies.
Authors: Gao, Juan (AUTHOR), Feng, Linya (AUTHOR), Wu, Birong (AUTHOR), Xia, Weihang (AUTHOR), Xie, Peng (AUTHOR), Ma, Shaodi (AUTHOR), Liu, Haixia (AUTHOR), Meng, Muzi (AUTHOR), Sun, Yehuan (AUTHOR)
Source: Neurological Sciences. Jan2024, Vol. 45 Issue 1, p27-36. 10p.
Subjects: Varicella-zoster virus diseases, Varicella-zoster virus, Disease risk factors, Dementia, Scientific observation, Online databases
Geographic Terms: Asia
Abstract: Purpose: The relationship between varicella zoster virus (VZV) infection and the risk of dementia has not been previously studied specifically. Therefore, this study sought to determine the relationship between studying VZV infection and dementia occurring in the general population by conducting an extensive meta-analysis of published cases. Method: A systematic literature search was conducted in seven online databases by October 31, 2022. Heterogeneity was tested by the I2 index. Pooled HR and 95% CI were used to estimate the effect of VZV infection on dementia. Sensitivity analyses and publication bias were also performed. Result: Nine studies involving 3,326,673 subjects were included. VZV infection was associated with an increased risk of dementia (HR = 1.11, 95% CI: 1.02–1.21). The risk of dementia was reduced in those who received antiviral therapy compared to those who did not (HR = 0.84, 95% CI: 0.71–0.99). In addition, VZV infection was found to be associated with an increased risk of developing dementia in the pooled results of the moderate quality study (HR = 1.81,95% CI: 1.27–2.59), and this association persisted when subgroup analyses were performed based on region (Asia: HR = 1.18,95% CI: 1.04–1.33). Conclusions: Our results suggest that VZV infection might increase the risk of developing dementia, but there is no clear mechanism about the true relationship, and since there is no effective treatment for dementia, and our results suggest that some populations can benefit from antiviral therapy, it is at least arguable that patients who develop VZV infection should be treated with appropriate antiviral medications. [ABSTRACT FROM AUTHOR]
Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: The association between varicella zoster virus and dementia: a systematic review and meta-analysis of observational studies.
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  Data: <searchLink fieldCode="AR" term="%22Gao%2C+Juan%22">Gao, Juan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Feng%2C+Linya%22">Feng, Linya</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wu%2C+Birong%22">Wu, Birong</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Xia%2C+Weihang%22">Xia, Weihang</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Xie%2C+Peng%22">Xie, Peng</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ma%2C+Shaodi%22">Ma, Shaodi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Haixia%22">Liu, Haixia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Meng%2C+Muzi%22">Meng, Muzi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sun%2C+Yehuan%22">Sun, Yehuan</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. Jan2024, Vol. 45 Issue 1, p27-36. 10p.
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  Data: <searchLink fieldCode="DE" term="%22Varicella-zoster+virus+diseases%22">Varicella-zoster virus diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Varicella-zoster+virus%22">Varicella-zoster virus</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+risk+factors%22">Disease risk factors</searchLink><br /><searchLink fieldCode="DE" term="%22Dementia%22">Dementia</searchLink><br /><searchLink fieldCode="DE" term="%22Scientific+observation%22">Scientific observation</searchLink><br /><searchLink fieldCode="DE" term="%22Online+databases%22">Online databases</searchLink>
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  Label: Abstract
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  Data: Purpose: The relationship between varicella zoster virus (VZV) infection and the risk of dementia has not been previously studied specifically. Therefore, this study sought to determine the relationship between studying VZV infection and dementia occurring in the general population by conducting an extensive meta-analysis of published cases. Method: A systematic literature search was conducted in seven online databases by October 31, 2022. Heterogeneity was tested by the I2 index. Pooled HR and 95% CI were used to estimate the effect of VZV infection on dementia. Sensitivity analyses and publication bias were also performed. Result: Nine studies involving 3,326,673 subjects were included. VZV infection was associated with an increased risk of dementia (HR = 1.11, 95% CI: 1.02–1.21). The risk of dementia was reduced in those who received antiviral therapy compared to those who did not (HR = 0.84, 95% CI: 0.71–0.99). In addition, VZV infection was found to be associated with an increased risk of developing dementia in the pooled results of the moderate quality study (HR = 1.81,95% CI: 1.27–2.59), and this association persisted when subgroup analyses were performed based on region (Asia: HR = 1.18,95% CI: 1.04–1.33). Conclusions: Our results suggest that VZV infection might increase the risk of developing dementia, but there is no clear mechanism about the true relationship, and since there is no effective treatment for dementia, and our results suggest that some populations can benefit from antiviral therapy, it is at least arguable that patients who develop VZV infection should be treated with appropriate antiviral medications. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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              Text: Jan2024
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