View in EDS HTML Full Text PDF Full Text

Association of psychological distress and DNA methylation: A 5‐year longitudinal population‐based twin study.

Saved in:
Bibliographic Details
Title: Association of psychological distress and DNA methylation: A 5‐year longitudinal population‐based twin study.
Authors: Hong, Xuanming (AUTHOR), Miao, Ke (AUTHOR), Cao, Weihua (AUTHOR), Lv, Jun (AUTHOR), Yu, Canqing (AUTHOR), Huang, Tao (AUTHOR), Sun, Dianjianyi (AUTHOR), Liao, Chunxiao (AUTHOR), Pang, Yuanjie (AUTHOR), Hu, Runhua (AUTHOR), Pang, Zengchang (AUTHOR), Yu, Min (AUTHOR), Wang, Hua (AUTHOR), Wu, Xianping (AUTHOR), Liu, Yu (AUTHOR), Gao, Wenjing (AUTHOR), Li, Liming (AUTHOR)
Source: Psychiatry & Clinical Neurosciences. Jan2024, Vol. 78 Issue 1, p51-59. 9p.
Subjects: DNA methylation, Psychological distress, Twin studies, False discovery rate, False memory syndrome
Abstract: Aim: To identify the psychological distress (PD)–associated 5′‐cytosine‐phosphate‐guanine‐3′ sites (CpGs), and investigate the temporal relationship between dynamic changes in DNA methylation (DNAm) and PD. Methods: This study included 1084 twins from the Chinese National Twin Register (CNTR). The CNTR conducted epidemiological investigations and blood withdrawal twice in 2013 and 2018. These included twins were used to perform epigenome‐wide association studies (EWASs) and to validate the previously reported PD‐associated CpGs selected from previous EWASs in PubMed, Embase, and the EWAS catalog. Next, a cross‐lagged study was performed to examine the temporality between changes in DNAm and PD in 308 twins who completed both 2013 and 2018 surveys. Results: The EWAS analysis of our study identified 25 CpGs. In the validation analysis, 741 CpGs from 29 previous EWASs on PD were selected for validation, and 101 CpGs were validated to be significant at a false discovery rate <0.05. The cross‐lagged analysis found a unidirectional path from PD to DNAm at 14 CpGs, while no sites showed significance from DNAm to PD. Conclusions: This study identified and validated PD‐related CpGs in a Chinese twin population, and suggested that PD may be the cause of changes in DNAm over time. The findings provide new insights into the molecular mechanisms underlying PD pathophysiology. [ABSTRACT FROM AUTHOR]
Copyright of Psychiatry & Clinical Neurosciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 174660638
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Association of psychological distress and DNA methylation: A 5‐year longitudinal population‐based twin study.
– Name: Author
  Label: Authors
  Group: Au
  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Hong%2C+Xuanming%22&quot;&gt;Hong, Xuanming&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Miao%2C+Ke%22&quot;&gt;Miao, Ke&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Cao%2C+Weihua%22&quot;&gt;Cao, Weihua&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Lv%2C+Jun%22&quot;&gt;Lv, Jun&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Yu%2C+Canqing%22&quot;&gt;Yu, Canqing&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Huang%2C+Tao%22&quot;&gt;Huang, Tao&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Sun%2C+Dianjianyi%22&quot;&gt;Sun, Dianjianyi&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Liao%2C+Chunxiao%22&quot;&gt;Liao, Chunxiao&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Pang%2C+Yuanjie%22&quot;&gt;Pang, Yuanjie&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Hu%2C+Runhua%22&quot;&gt;Hu, Runhua&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Pang%2C+Zengchang%22&quot;&gt;Pang, Zengchang&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Yu%2C+Min%22&quot;&gt;Yu, Min&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Wang%2C+Hua%22&quot;&gt;Wang, Hua&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Wu%2C+Xianping%22&quot;&gt;Wu, Xianping&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Liu%2C+Yu%22&quot;&gt;Liu, Yu&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Gao%2C+Wenjing%22&quot;&gt;Gao, Wenjing&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Li%2C+Liming%22&quot;&gt;Li, Liming&lt;/searchLink&gt; (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Psychiatry+%26+Clinical+Neurosciences%22&quot;&gt;Psychiatry &amp; Clinical Neurosciences&lt;/searchLink&gt;. Jan2024, Vol. 78 Issue 1, p51-59. 9p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22DNA+methylation%22&quot;&gt;DNA methylation&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Psychological+distress%22&quot;&gt;Psychological distress&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Twin+studies%22&quot;&gt;Twin studies&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22False+discovery+rate%22&quot;&gt;False discovery rate&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22False+memory+syndrome%22&quot;&gt;False memory syndrome&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Aim: To identify the psychological distress (PD)–associated 5′‐cytosine‐phosphate‐guanine‐3′ sites (CpGs), and investigate the temporal relationship between dynamic changes in DNA methylation (DNAm) and PD. Methods: This study included 1084 twins from the Chinese National Twin Register (CNTR). The CNTR conducted epidemiological investigations and blood withdrawal twice in 2013 and 2018. These included twins were used to perform epigenome‐wide association studies (EWASs) and to validate the previously reported PD‐associated CpGs selected from previous EWASs in PubMed, Embase, and the EWAS catalog. Next, a cross‐lagged study was performed to examine the temporality between changes in DNAm and PD in 308 twins who completed both 2013 and 2018 surveys. Results: The EWAS analysis of our study identified 25 CpGs. In the validation analysis, 741 CpGs from 29 previous EWASs on PD were selected for validation, and 101 CpGs were validated to be significant at a false discovery rate &lt;0.05. The cross‐lagged analysis found a unidirectional path from PD to DNAm at 14 CpGs, while no sites showed significance from DNAm to PD. Conclusions: This study identified and validated PD‐related CpGs in a Chinese twin population, and suggested that PD may be the cause of changes in DNAm over time. The findings provide new insights into the molecular mechanisms underlying PD pathophysiology. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: &lt;i&gt;Copyright of Psychiatry &amp; Clinical Neurosciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=174660638
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/pcn.13606
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 9
        StartPage: 51
    Subjects:
      – SubjectFull: DNA methylation
        Type: general
      – SubjectFull: Psychological distress
        Type: general
      – SubjectFull: Twin studies
        Type: general
      – SubjectFull: False discovery rate
        Type: general
      – SubjectFull: False memory syndrome
        Type: general
    Titles:
      – TitleFull: Association of psychological distress and DNA methylation: A 5‐year longitudinal population‐based twin study.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Hong, Xuanming
      – PersonEntity:
          Name:
            NameFull: Miao, Ke
      – PersonEntity:
          Name:
            NameFull: Cao, Weihua
      – PersonEntity:
          Name:
            NameFull: Lv, Jun
      – PersonEntity:
          Name:
            NameFull: Yu, Canqing
      – PersonEntity:
          Name:
            NameFull: Huang, Tao
      – PersonEntity:
          Name:
            NameFull: Sun, Dianjianyi
      – PersonEntity:
          Name:
            NameFull: Liao, Chunxiao
      – PersonEntity:
          Name:
            NameFull: Pang, Yuanjie
      – PersonEntity:
          Name:
            NameFull: Hu, Runhua
      – PersonEntity:
          Name:
            NameFull: Pang, Zengchang
      – PersonEntity:
          Name:
            NameFull: Yu, Min
      – PersonEntity:
          Name:
            NameFull: Wang, Hua
      – PersonEntity:
          Name:
            NameFull: Wu, Xianping
      – PersonEntity:
          Name:
            NameFull: Liu, Yu
      – PersonEntity:
          Name:
            NameFull: Gao, Wenjing
      – PersonEntity:
          Name:
            NameFull: Li, Liming
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 01
              Text: Jan2024
              Type: published
              Y: 2024
          Identifiers:
            – Type: issn-print
              Value: 13231316
          Numbering:
            – Type: volume
              Value: 78
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Psychiatry & Clinical Neurosciences
              Type: main
ResultId 1