View in EDS HTML Full Text PDF Full Text

Neurocognitive development after pediatric brain tumor - a longitudinal, retrospective cohort study.

Saved in:
Bibliographic Details
Title: Neurocognitive development after pediatric brain tumor - a longitudinal, retrospective cohort study.
Authors: Tonning Olsson, Ingrid (AUTHOR), Lundgren, Johan (AUTHOR), Hjorth, Lars (AUTHOR), Munck Af Rosenschöld, Per (AUTHOR), Hammar, Åsa (AUTHOR), Perrin, Sean (AUTHOR)
Source: Child Neuropsychology. Feb2024, Vol. 30 Issue 1, p22-44. 23p.
Subjects: Brain tumors, Disabilities, Verbal learning, Cohort analysis, Multilevel models
Abstract: Survivors of Pediatric Brain Tumors (PBTs) treated with cranial radiation therapy (CRT) often experience a decline in neurocognitive test scores. Less is known about the neurocognitive development of non-irradiated survivors of PBTs. The aim of this study was to statistically model neurocognitive development after PBT in both irradiated and non-irradiated survivors and to find clinical variables associated with the rate of decline in neurocognitive scores. A total of 151 survivors were included in the study. Inclusion criteria: Diagnosis of PBT between 2001 and 2013 or earlier diagnosis of PBT and turning 18 years of age between 2006 and 2013. Exclusion criteria: Death within a year from diagnosis, neurocutaneous syndromes, severe intellectual disability. Clinical neurocognitive data were collected retrospectively from medical records. Multilevel linear modeling was used to evaluate the rate of decline in neurocognitive measures and factors associated with the same. A decline was found in most measures for both irradiated and non-irradiated survivors. Ventriculo-peritoneal (VP) shunting and treatment with whole-brain radiation therapy (WBRT) were associated with a faster decline in neurocognitive scores. Male sex and supratentorial lateral tumor were associated with lower scores. Verbal learning measures were either stable or improving. Survivors of PBTs show a pattern of decline in neurocognitive scores irrespective of treatment received, which suggests the need for routine screening for neurocognitive rehabilitation. However, survivors treated with WBRT and/or a VP shunt declined at a faster rate and appear to be at the highest risk of negative neurocognitive outcomes and to have the greatest need for neurocognitive rehabilitation. [ABSTRACT FROM AUTHOR]
Copyright of Child Neuropsychology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 174662221
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Neurocognitive development after pediatric brain tumor - a longitudinal, retrospective cohort study.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Tonning+Olsson%2C+Ingrid%22">Tonning Olsson, Ingrid</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lundgren%2C+Johan%22">Lundgren, Johan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hjorth%2C+Lars%22">Hjorth, Lars</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Munck+Af+Rosenschöld%2C+Per%22">Munck Af Rosenschöld, Per</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hammar%2C+Åsa%22">Hammar, Åsa</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Perrin%2C+Sean%22">Perrin, Sean</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Child+Neuropsychology%22">Child Neuropsychology</searchLink>. Feb2024, Vol. 30 Issue 1, p22-44. 23p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Brain+tumors%22">Brain tumors</searchLink><br /><searchLink fieldCode="DE" term="%22Disabilities%22">Disabilities</searchLink><br /><searchLink fieldCode="DE" term="%22Verbal+learning%22">Verbal learning</searchLink><br /><searchLink fieldCode="DE" term="%22Cohort+analysis%22">Cohort analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Multilevel+models%22">Multilevel models</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Survivors of Pediatric Brain Tumors (PBTs) treated with cranial radiation therapy (CRT) often experience a decline in neurocognitive test scores. Less is known about the neurocognitive development of non-irradiated survivors of PBTs. The aim of this study was to statistically model neurocognitive development after PBT in both irradiated and non-irradiated survivors and to find clinical variables associated with the rate of decline in neurocognitive scores. A total of 151 survivors were included in the study. Inclusion criteria: Diagnosis of PBT between 2001 and 2013 or earlier diagnosis of PBT and turning 18 years of age between 2006 and 2013. Exclusion criteria: Death within a year from diagnosis, neurocutaneous syndromes, severe intellectual disability. Clinical neurocognitive data were collected retrospectively from medical records. Multilevel linear modeling was used to evaluate the rate of decline in neurocognitive measures and factors associated with the same. A decline was found in most measures for both irradiated and non-irradiated survivors. Ventriculo-peritoneal (VP) shunting and treatment with whole-brain radiation therapy (WBRT) were associated with a faster decline in neurocognitive scores. Male sex and supratentorial lateral tumor were associated with lower scores. Verbal learning measures were either stable or improving. Survivors of PBTs show a pattern of decline in neurocognitive scores irrespective of treatment received, which suggests the need for routine screening for neurocognitive rehabilitation. However, survivors treated with WBRT and/or a VP shunt declined at a faster rate and appear to be at the highest risk of negative neurocognitive outcomes and to have the greatest need for neurocognitive rehabilitation. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Child Neuropsychology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=174662221
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/09297049.2023.2172149
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 23
        StartPage: 22
    Subjects:
      – SubjectFull: Brain tumors
        Type: general
      – SubjectFull: Disabilities
        Type: general
      – SubjectFull: Verbal learning
        Type: general
      – SubjectFull: Cohort analysis
        Type: general
      – SubjectFull: Multilevel models
        Type: general
    Titles:
      – TitleFull: Neurocognitive development after pediatric brain tumor - a longitudinal, retrospective cohort study.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Tonning Olsson, Ingrid
      – PersonEntity:
          Name:
            NameFull: Lundgren, Johan
      – PersonEntity:
          Name:
            NameFull: Hjorth, Lars
      – PersonEntity:
          Name:
            NameFull: Munck Af Rosenschöld, Per
      – PersonEntity:
          Name:
            NameFull: Hammar, Åsa
      – PersonEntity:
          Name:
            NameFull: Perrin, Sean
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 02
              Text: Feb2024
              Type: published
              Y: 2024
          Identifiers:
            – Type: issn-print
              Value: 09297049
          Numbering:
            – Type: volume
              Value: 30
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Child Neuropsychology
              Type: main
ResultId 1