View in EDS HTML Full Text PDF Full Text

A naturalistic effectiveness study of maintenance therapies for the bipolar disorders.

Saved in:
Bibliographic Details
Title: A naturalistic effectiveness study of maintenance therapies for the bipolar disorders.
Authors: Spoelma, Michael J. (AUTHOR), Leidreiter, Joanne (AUTHOR), Bayes, Adam (AUTHOR), Jebejian, Artin (AUTHOR), Parker, Gordon (AUTHOR)
Source: Acta Psychiatrica Scandinavica. Feb2024, Vol. 149 Issue 2, p98-109. 12p.
Subjects: Bipolar disorder, Lamotrigine, Lithium carbonate, Olanzapine
Abstract: Background: Treatment decision‐making for individuals with bipolar disorder can be difficult. Recommendations from clinical practice guidelines can be affected by multiple methodological limitations, while pharmaco‐epidemiological data suggest great variety in prescription practices across regions. Given these inconsistencies, this study aimed to provide an alternative perspective on the effectiveness of common bipolar disorder maintenance treatments through considering naturalistic data. Methods: A total of 246 individuals with bipolar disorder (84 bipolar I [BP‐I], 162 bipolar II [BP‐II]) were recruited through clinics and/or websites. All were euthymic and had trialled at least one mood stabiliser. They completed an online survey containing questions on demographics, clinical variables, symptomatology, and the effectiveness/side effect profiles of any mood stabilisers (MSTs) or atypical antipsychotics (AAPs) that they have taken. Results: Lithium and lamotrigine were the most commonly prescribed MSTs and the most effective at mood stabilisation. Lithium and lamotrigine appeared marginally more effective for BP‐I and BP‐II respectively, however, only the latter difference was statistically significant. Furthermore, lamotrigine had the more favourable side effect profile. Amongst the AAPs, quetiapine and olanzapine were the most commonly prescribed, but they were negligibly superior to other AAPs. Conclusion: This study clearly established a preference for lamotrigine in the maintenance treatment of BP‐II. While the literature consistently emphasises the primacy of lithium in bipolar disorder treatment, its side effect profile as observed in this study remains a concern. Future research considering moderators of treatment response and concomitant medications could help to identify further nuances to consider for treatment decision‐making. [ABSTRACT FROM AUTHOR]
Copyright of Acta Psychiatrica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 174779928
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: A naturalistic effectiveness study of maintenance therapies for the bipolar disorders.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Spoelma%2C+Michael+J%2E%22">Spoelma, Michael J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Leidreiter%2C+Joanne%22">Leidreiter, Joanne</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bayes%2C+Adam%22">Bayes, Adam</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jebejian%2C+Artin%22">Jebejian, Artin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Parker%2C+Gordon%22">Parker, Gordon</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Acta+Psychiatrica+Scandinavica%22">Acta Psychiatrica Scandinavica</searchLink>. Feb2024, Vol. 149 Issue 2, p98-109. 12p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Bipolar+disorder%22">Bipolar disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Lamotrigine%22">Lamotrigine</searchLink><br /><searchLink fieldCode="DE" term="%22Lithium+carbonate%22">Lithium carbonate</searchLink><br /><searchLink fieldCode="DE" term="%22Olanzapine%22">Olanzapine</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: Treatment decision‐making for individuals with bipolar disorder can be difficult. Recommendations from clinical practice guidelines can be affected by multiple methodological limitations, while pharmaco‐epidemiological data suggest great variety in prescription practices across regions. Given these inconsistencies, this study aimed to provide an alternative perspective on the effectiveness of common bipolar disorder maintenance treatments through considering naturalistic data. Methods: A total of 246 individuals with bipolar disorder (84 bipolar I [BP‐I], 162 bipolar II [BP‐II]) were recruited through clinics and/or websites. All were euthymic and had trialled at least one mood stabiliser. They completed an online survey containing questions on demographics, clinical variables, symptomatology, and the effectiveness/side effect profiles of any mood stabilisers (MSTs) or atypical antipsychotics (AAPs) that they have taken. Results: Lithium and lamotrigine were the most commonly prescribed MSTs and the most effective at mood stabilisation. Lithium and lamotrigine appeared marginally more effective for BP‐I and BP‐II respectively, however, only the latter difference was statistically significant. Furthermore, lamotrigine had the more favourable side effect profile. Amongst the AAPs, quetiapine and olanzapine were the most commonly prescribed, but they were negligibly superior to other AAPs. Conclusion: This study clearly established a preference for lamotrigine in the maintenance treatment of BP‐II. While the literature consistently emphasises the primacy of lithium in bipolar disorder treatment, its side effect profile as observed in this study remains a concern. Future research considering moderators of treatment response and concomitant medications could help to identify further nuances to consider for treatment decision‐making. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Acta Psychiatrica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=174779928
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/acps.13646
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 12
        StartPage: 98
    Subjects:
      – SubjectFull: Bipolar disorder
        Type: general
      – SubjectFull: Lamotrigine
        Type: general
      – SubjectFull: Lithium carbonate
        Type: general
      – SubjectFull: Olanzapine
        Type: general
    Titles:
      – TitleFull: A naturalistic effectiveness study of maintenance therapies for the bipolar disorders.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Spoelma, Michael J.
      – PersonEntity:
          Name:
            NameFull: Leidreiter, Joanne
      – PersonEntity:
          Name:
            NameFull: Bayes, Adam
      – PersonEntity:
          Name:
            NameFull: Jebejian, Artin
      – PersonEntity:
          Name:
            NameFull: Parker, Gordon
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 02
              Text: Feb2024
              Type: published
              Y: 2024
          Identifiers:
            – Type: issn-print
              Value: 0001690X
          Numbering:
            – Type: volume
              Value: 149
            – Type: issue
              Value: 2
          Titles:
            – TitleFull: Acta Psychiatrica Scandinavica
              Type: main
ResultId 1