Theta burst stimulation add on to dialectical behavioral therapy in borderline-personality-disorder: methods and design of a randomized, single-blind, placebo-controlled pilot trial.
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| Title: | Theta burst stimulation add on to dialectical behavioral therapy in borderline-personality-disorder: methods and design of a randomized, single-blind, placebo-controlled pilot trial. |
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| Authors: | Kujovic, Milenko (AUTHOR), Benz, Daniel (AUTHOR), Riesbeck, Mathias (AUTHOR), Bahr, Christian (AUTHOR), Kriegs, Christian (AUTHOR), Reinermann, Dirk (AUTHOR), Jänner, Michaela (AUTHOR), Neufang, Susanne (AUTHOR), Margittai, Zsofia (AUTHOR), Kamp, Daniel (AUTHOR), Plewnia, Christian (AUTHOR), Meisenzahl, Eva (AUTHOR) |
| Source: | European Archives of Psychiatry & Clinical Neuroscience. Feb2024, Vol. 274 Issue 1, p87-96. 10p. |
| Subjects: | Behavior therapy, Transcranial magnetic stimulation, Borderline personality disorder, Magnetic resonance imaging, Treatment effectiveness |
| Abstract: | Specialized psychotherapeutic treatments like dialectical behavioral therapy (DBT) are recommended as first treatment for borderline personality disorder (BPD). In recent years, studies have emerged that focus on repetitive transcranial magnetic stimulation (rTMS) in BPD. Both have independently demonstrated efficacy in the treatment of BPD. Intermitted theta burst stimulation (iTBS), a modified design of rTMS, is thought to increase the excitability of neurons and could be a supplement to psychotherapy in addition to being a standalone treatment. However, no studies to date have investigated the combination of DBT and rTMS/iTBS. This study protocol describes the methods and design of a randomized, single-blinded, sham-controlled clinical pilot study in which BPD patients will be randomly assigned to either iTBS or sham during four consecutive weeks (20 sessions in total) in addition to standardized DBT treatment. The stimulation will focus on the unilateral stimulation of the left dorsolateral prefrontal cortex (DLPFC), which plays an important role in the control of impulsivity and risk-taking. Primary outcome is the difference in borderline symptomatology, while secondary target criteria are depressive symptoms, general functional level, impulsivity and self-compassion. Statistical analysis of therapy response will be conducted by Mixed Model Repeated Measurement using a 2 × 2-factorial between-subjects design with the between-subject factor stimulation (TMS vs. Sham) and the within-subject factor time (T0 vs. T1). Furthermore, structural magnetic resonance imaging (MRI) will be conducted and analyzed. The study will provide evidence and insight on whether iTBS has an enhancing effect as add-on to DBT in BPD. Trial registration: drks.de (DRKS00020413) registered 13/01/2020. [ABSTRACT FROM AUTHOR] |
| Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 174799616 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Theta burst stimulation add on to dialectical behavioral therapy in borderline-personality-disorder: methods and design of a randomized, single-blind, placebo-controlled pilot trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Kujovic%2C+Milenko%22">Kujovic, Milenko</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Benz%2C+Daniel%22">Benz, Daniel</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Riesbeck%2C+Mathias%22">Riesbeck, Mathias</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bahr%2C+Christian%22">Bahr, Christian</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kriegs%2C+Christian%22">Kriegs, Christian</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Reinermann%2C+Dirk%22">Reinermann, Dirk</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jänner%2C+Michaela%22">Jänner, Michaela</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Neufang%2C+Susanne%22">Neufang, Susanne</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Margittai%2C+Zsofia%22">Margittai, Zsofia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kamp%2C+Daniel%22">Kamp, Daniel</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Plewnia%2C+Christian%22">Plewnia, Christian</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Meisenzahl%2C+Eva%22">Meisenzahl, Eva</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Archives+of+Psychiatry+%26+Clinical+Neuroscience%22">European Archives of Psychiatry & Clinical Neuroscience</searchLink>. Feb2024, Vol. 274 Issue 1, p87-96. 10p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Behavior+therapy%22">Behavior therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Transcranial+magnetic+stimulation%22">Transcranial magnetic stimulation</searchLink><br /><searchLink fieldCode="DE" term="%22Borderline+personality+disorder%22">Borderline personality disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+effectiveness%22">Treatment effectiveness</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Specialized psychotherapeutic treatments like dialectical behavioral therapy (DBT) are recommended as first treatment for borderline personality disorder (BPD). In recent years, studies have emerged that focus on repetitive transcranial magnetic stimulation (rTMS) in BPD. Both have independently demonstrated efficacy in the treatment of BPD. Intermitted theta burst stimulation (iTBS), a modified design of rTMS, is thought to increase the excitability of neurons and could be a supplement to psychotherapy in addition to being a standalone treatment. However, no studies to date have investigated the combination of DBT and rTMS/iTBS. This study protocol describes the methods and design of a randomized, single-blinded, sham-controlled clinical pilot study in which BPD patients will be randomly assigned to either iTBS or sham during four consecutive weeks (20 sessions in total) in addition to standardized DBT treatment. The stimulation will focus on the unilateral stimulation of the left dorsolateral prefrontal cortex (DLPFC), which plays an important role in the control of impulsivity and risk-taking. Primary outcome is the difference in borderline symptomatology, while secondary target criteria are depressive symptoms, general functional level, impulsivity and self-compassion. Statistical analysis of therapy response will be conducted by Mixed Model Repeated Measurement using a 2 × 2-factorial between-subjects design with the between-subject factor stimulation (TMS vs. Sham) and the within-subject factor time (T0 vs. T1). Furthermore, structural magnetic resonance imaging (MRI) will be conducted and analyzed. The study will provide evidence and insight on whether iTBS has an enhancing effect as add-on to DBT in BPD. Trial registration: drks.de (DRKS00020413) registered 13/01/2020. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=174799616 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00406-023-01692-w Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 10 StartPage: 87 Subjects: – SubjectFull: Behavior therapy Type: general – SubjectFull: Transcranial magnetic stimulation Type: general – SubjectFull: Borderline personality disorder Type: general – SubjectFull: Magnetic resonance imaging Type: general – SubjectFull: Treatment effectiveness Type: general Titles: – TitleFull: Theta burst stimulation add on to dialectical behavioral therapy in borderline-personality-disorder: methods and design of a randomized, single-blind, placebo-controlled pilot trial. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Kujovic, Milenko – PersonEntity: Name: NameFull: Benz, Daniel – PersonEntity: Name: NameFull: Riesbeck, Mathias – PersonEntity: Name: NameFull: Bahr, Christian – PersonEntity: Name: NameFull: Kriegs, Christian – PersonEntity: Name: NameFull: Reinermann, Dirk – PersonEntity: Name: NameFull: Jänner, Michaela – PersonEntity: Name: NameFull: Neufang, Susanne – PersonEntity: Name: NameFull: Margittai, Zsofia – PersonEntity: Name: NameFull: Kamp, Daniel – PersonEntity: Name: NameFull: Plewnia, Christian – PersonEntity: Name: NameFull: Meisenzahl, Eva IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 02 Text: Feb2024 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 09401334 Numbering: – Type: volume Value: 274 – Type: issue Value: 1 Titles: – TitleFull: European Archives of Psychiatry & Clinical Neuroscience Type: main |
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