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Pregnancy, fertile life factors, and associated clinical course in PRKN early-onset Parkinson's disease.

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Title: Pregnancy, fertile life factors, and associated clinical course in PRKN early-onset Parkinson's disease.
Authors: Bovenzi, Roberta (AUTHOR), Conti, Matteo (AUTHOR), Degoli, Giulia Rebecca (AUTHOR), Cerroni, Rocco (AUTHOR), Artusi, Carlo Alberto (AUTHOR), Pierantozzi, Mariangela (AUTHOR), Stefani, Alessandro (AUTHOR), Mercuri, Nicola Biagio (AUTHOR), Schirinzi, Tommaso (AUTHOR)
Source: Neurological Sciences. Feb2024, Vol. 45 Issue 2, p591-599. 9p.
Subjects: Parkinson's disease, Pregnancy, Patient experience, Childbearing age, Menstrual cycle, Menstruation disorders, Infertility
Abstract: Introduction: As the most common cause of autosomal recessive early onset Parkinson's disease (EOPD), parkin type Parkinson's disease (PRKN-PD) may affect female patients in childbearing age. Accordingly, issues related to fertility must be adequately addressed. Here, we landscaped fertile life factors and pregnancy course of a PRKN-PD cohort, including both novel cases directly observed at our center and published ones. Methods: Six patients with confirmed PRKN-PD were examined by a structured interview on reproductive factors and associated modifications of PD disturbances, including one case followed up throughout pregnancy which was described in greater detail. Six studies reporting fertile life factors of nine PRKN-PD patients were reviewed collecting homogeneous data on fertile life and pregnancy course. Results: PRKN-PD female patients experienced motor fluctuations with the menstrual cycle, pregnancy, and puerperium, which suggests a role for sex hormones in PD clinical burden. In some cases, abortion and miscarriages occurred during the organogenesis phase in patients receiving oral antiparkinsonian therapy; however, levodopa/benserazide monotherapy resulted to be the safest choice in pregnancy. Conclusion: Collectively these data disclose the importance of pre-conception counseling in childbearing age PRKN-PD patients and EOPD in general. [ABSTRACT FROM AUTHOR]
Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Pregnancy, fertile life factors, and associated clinical course in PRKN early-onset Parkinson's disease.
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  Data: <searchLink fieldCode="AR" term="%22Bovenzi%2C+Roberta%22">Bovenzi, Roberta</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Conti%2C+Matteo%22">Conti, Matteo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Degoli%2C+Giulia+Rebecca%22">Degoli, Giulia Rebecca</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cerroni%2C+Rocco%22">Cerroni, Rocco</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Artusi%2C+Carlo+Alberto%22">Artusi, Carlo Alberto</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pierantozzi%2C+Mariangela%22">Pierantozzi, Mariangela</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Stefani%2C+Alessandro%22">Stefani, Alessandro</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mercuri%2C+Nicola+Biagio%22">Mercuri, Nicola Biagio</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Schirinzi%2C+Tommaso%22">Schirinzi, Tommaso</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. Feb2024, Vol. 45 Issue 2, p591-599. 9p.
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  Data: <searchLink fieldCode="DE" term="%22Parkinson's+disease%22">Parkinson's disease</searchLink><br /><searchLink fieldCode="DE" term="%22Pregnancy%22">Pregnancy</searchLink><br /><searchLink fieldCode="DE" term="%22Patient+experience%22">Patient experience</searchLink><br /><searchLink fieldCode="DE" term="%22Childbearing+age%22">Childbearing age</searchLink><br /><searchLink fieldCode="DE" term="%22Menstrual+cycle%22">Menstrual cycle</searchLink><br /><searchLink fieldCode="DE" term="%22Menstruation+disorders%22">Menstruation disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Infertility%22">Infertility</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Introduction: As the most common cause of autosomal recessive early onset Parkinson's disease (EOPD), parkin type Parkinson's disease (PRKN-PD) may affect female patients in childbearing age. Accordingly, issues related to fertility must be adequately addressed. Here, we landscaped fertile life factors and pregnancy course of a PRKN-PD cohort, including both novel cases directly observed at our center and published ones. Methods: Six patients with confirmed PRKN-PD were examined by a structured interview on reproductive factors and associated modifications of PD disturbances, including one case followed up throughout pregnancy which was described in greater detail. Six studies reporting fertile life factors of nine PRKN-PD patients were reviewed collecting homogeneous data on fertile life and pregnancy course. Results: PRKN-PD female patients experienced motor fluctuations with the menstrual cycle, pregnancy, and puerperium, which suggests a role for sex hormones in PD clinical burden. In some cases, abortion and miscarriages occurred during the organogenesis phase in patients receiving oral antiparkinsonian therapy; however, levodopa/benserazide monotherapy resulted to be the safest choice in pregnancy. Conclusion: Collectively these data disclose the importance of pre-conception counseling in childbearing age PRKN-PD patients and EOPD in general. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – SubjectFull: Patient experience
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      – SubjectFull: Childbearing age
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              Text: Feb2024
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