Prevalence and correlates of fatigue in amyotrophic lateral sclerosis: A systematic review and meta-analysis.
Saved in:
| Title: | Prevalence and correlates of fatigue in amyotrophic lateral sclerosis: A systematic review and meta-analysis. |
|---|---|
| Authors: | Hamad, Abdullah Ashraf (AUTHOR), Amer, Basma Ehab (AUTHOR), Abbas, Nagham Bushara (AUTHOR), Alnajjar, Asmaa Zakria (AUTHOR), Meshref, Mostafa (AUTHOR) |
| Source: | Neurological Sciences. Feb2024, Vol. 45 Issue 2, p485-493. 9p. |
| Subjects: | Amyotrophic lateral sclerosis, Fatigue (Physiology), Motor neuron diseases |
| Abstract: | Objectives: This systematic review and meta-analysis aimed to determine the frequency and correlates of fatigue in patients with amyotrophic lateral sclerosis (ALS). Methods: Three databases were searched up to 2nd May 2023 to identify studies reporting fatigue frequency in ALS. Studies included had to identify ALS patients through one of ALS diagnostic criteria and measure fatigue by a validated tool with a specific cut-off value. Meta-analysis was conducted using RStudio's "meta" package with a random-effects model. Subgroup analyses and meta-regression explored the relationship between fatigue frequency in ALS and different covariates. Results: Eleven studies, compromising 1072 patients, met the inclusion criteria and were included in our analysis. The pooled frequency of fatigue across all studies was 48% (95% CI = 40% to 57%). Our subgroup analysis based on the ALSFRS-R revealed a higher frequency of fatigue in studies with lower scores (< 30) compared to those with higher scores (≥ 30), with a pooled frequency of 62% (95% CI = 43% to 79%) and 43% (95% CI = 37% to 49%), respectively. Also, the meta-regression analysis showed a significant negative association between fatigue and ALSFRS-R mean (P = 0.02). The included studies reported an association between fatigue and lower functional status and poorer quality of life in patients with ALS. Conclusion: Our findings suggest that fatigue is prevalent in almost half of ALS patients and is associated with lower functional status and poorer quality of life, highlighting the importance of assessing and managing fatigue in ALS patients. [ABSTRACT FROM AUTHOR] |
| Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
|
Full text is not displayed to guests.
Login for full access.
|
|
| FullText | Links: – Type: pdflink Text: Availability: 1 |
|---|---|
| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 174819446 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Prevalence and correlates of fatigue in amyotrophic lateral sclerosis: A systematic review and meta-analysis. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Hamad%2C+Abdullah+Ashraf%22">Hamad, Abdullah Ashraf</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Amer%2C+Basma+Ehab%22">Amer, Basma Ehab</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Abbas%2C+Nagham+Bushara%22">Abbas, Nagham Bushara</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Alnajjar%2C+Asmaa+Zakria%22">Alnajjar, Asmaa Zakria</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Meshref%2C+Mostafa%22">Meshref, Mostafa</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. Feb2024, Vol. 45 Issue 2, p485-493. 9p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Amyotrophic+lateral+sclerosis%22">Amyotrophic lateral sclerosis</searchLink><br /><searchLink fieldCode="DE" term="%22Fatigue+%28Physiology%29%22">Fatigue (Physiology)</searchLink><br /><searchLink fieldCode="DE" term="%22Motor+neuron+diseases%22">Motor neuron diseases</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Objectives: This systematic review and meta-analysis aimed to determine the frequency and correlates of fatigue in patients with amyotrophic lateral sclerosis (ALS). Methods: Three databases were searched up to 2nd May 2023 to identify studies reporting fatigue frequency in ALS. Studies included had to identify ALS patients through one of ALS diagnostic criteria and measure fatigue by a validated tool with a specific cut-off value. Meta-analysis was conducted using RStudio's "meta" package with a random-effects model. Subgroup analyses and meta-regression explored the relationship between fatigue frequency in ALS and different covariates. Results: Eleven studies, compromising 1072 patients, met the inclusion criteria and were included in our analysis. The pooled frequency of fatigue across all studies was 48% (95% CI = 40% to 57%). Our subgroup analysis based on the ALSFRS-R revealed a higher frequency of fatigue in studies with lower scores (< 30) compared to those with higher scores (≥ 30), with a pooled frequency of 62% (95% CI = 43% to 79%) and 43% (95% CI = 37% to 49%), respectively. Also, the meta-regression analysis showed a significant negative association between fatigue and ALSFRS-R mean (P = 0.02). The included studies reported an association between fatigue and lower functional status and poorer quality of life in patients with ALS. Conclusion: Our findings suggest that fatigue is prevalent in almost half of ALS patients and is associated with lower functional status and poorer quality of life, highlighting the importance of assessing and managing fatigue in ALS patients. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=174819446 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10072-023-07119-7 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 9 StartPage: 485 Subjects: – SubjectFull: Amyotrophic lateral sclerosis Type: general – SubjectFull: Fatigue (Physiology) Type: general – SubjectFull: Motor neuron diseases Type: general Titles: – TitleFull: Prevalence and correlates of fatigue in amyotrophic lateral sclerosis: A systematic review and meta-analysis. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Hamad, Abdullah Ashraf – PersonEntity: Name: NameFull: Amer, Basma Ehab – PersonEntity: Name: NameFull: Abbas, Nagham Bushara – PersonEntity: Name: NameFull: Alnajjar, Asmaa Zakria – PersonEntity: Name: NameFull: Meshref, Mostafa IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 02 Text: Feb2024 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 15901874 Numbering: – Type: volume Value: 45 – Type: issue Value: 2 Titles: – TitleFull: Neurological Sciences Type: main |
| ResultId | 1 |
