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Incidence of SARS-CoV-2 infection in patients with multiple sclerosis who received SARS-CoV-2 vaccines and are under treatment with high-efficacy therapies in Argentina.

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Title: Incidence of SARS-CoV-2 infection in patients with multiple sclerosis who received SARS-CoV-2 vaccines and are under treatment with high-efficacy therapies in Argentina.
Authors: Carnero Contentti, Edgar (AUTHOR), López, Pablo A. (AUTHOR), Pappolla, Agustín (AUTHOR), Alonso, Ricardo (AUTHOR), Silva, Berenice (AUTHOR), Deri, Norma (AUTHOR), Balbuena, María E. (AUTHOR), Burgos, Marcos (AUTHOR), Luetic, Geraldine (AUTHOR), Alvez Pinheiro, Amelia (AUTHOR), Cabrera, Mariela (AUTHOR), Hryb, Javier (AUTHOR), Nofal, Pedro (AUTHOR), Pestchanker, Claudia (AUTHOR), Vrech, Carlos (AUTHOR), Tavolini, Darío (AUTHOR), Tkachuk, Verónica (AUTHOR), Zanga, Gisela (AUTHOR), Marrodan, Mariano (AUTHOR), Ysrraelit, María Célica (AUTHOR)
Source: Neurological Sciences. Feb2024, Vol. 45 Issue 2, p379-389. 11p.
Subjects: COVID-19 vaccines, Breakthrough infections, COVID-19, Multiple sclerosis, SARS-CoV-2
Geographic Terms: Argentina
Abstract: We aimed to evaluate the incidence of SARS-CoV-2 breakthrough infection of SARS-CoV-2 vaccines in people with MS (PwMS) on high-efficacy disease-modifying therapies (HET) included in the national MS registry in Argentina (RelevarEM). Methods: Non-interventional, retrospective cohort study that collected information directly from RelevarEM. Adult PwMS who had been treated for at least 6 months with a HET (ocrelizumab, natalizumab, alemtuzumab, cladribine) who had received at least two doses of SARS-CoV-2 vaccines available in Argentina were included. Full course of vaccination was considered after the second dose of the corresponding vaccines. Cumulative incidence of SARS-CoV-2 infection was reported for the whole cohort by Kaplan–Meier survival curves (which is expressed in percentage) as well as incidence density (which is expressed per 10.000 patients/day with 95% CI). Results: Two hundred twenty-eight PwMS were included. Most frequent first and second dose received was AstraZeneca vaccine, followed by Sputnik vaccine. Most frequent HETs used in included patients were cladribine in 79 (34.8%). We found an incidence density of breakthrough COVID-19 infection of 3.5 × 10.000 patients/day (95% CI 2.3–6.7) after vaccination in Argentina. We described the incidence rate after vaccination for every HET used, it being significantly higher for ocrelizumab compared with other HETs (p = 0.005). Only five patients presented a relapse during the follow-up period with no differences regarding the pre-vaccination period. Conclusions: We found an incidence density of breakthrough COVID-19 infection of 3.5 × 10.000 patients/day (95% CI 2.3–6.7) after vaccination in Argentina. [ABSTRACT FROM AUTHOR]
Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Incidence of SARS-CoV-2 infection in patients with multiple sclerosis who received SARS-CoV-2 vaccines and are under treatment with high-efficacy therapies in Argentina.
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  Data: <searchLink fieldCode="AR" term="%22Carnero+Contentti%2C+Edgar%22">Carnero Contentti, Edgar</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22López%2C+Pablo+A%2E%22">López, Pablo A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pappolla%2C+Agustín%22">Pappolla, Agustín</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Alonso%2C+Ricardo%22">Alonso, Ricardo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Silva%2C+Berenice%22">Silva, Berenice</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Deri%2C+Norma%22">Deri, Norma</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Balbuena%2C+María+E%2E%22">Balbuena, María E.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Burgos%2C+Marcos%22">Burgos, Marcos</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Luetic%2C+Geraldine%22">Luetic, Geraldine</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Alvez+Pinheiro%2C+Amelia%22">Alvez Pinheiro, Amelia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cabrera%2C+Mariela%22">Cabrera, Mariela</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hryb%2C+Javier%22">Hryb, Javier</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nofal%2C+Pedro%22">Nofal, Pedro</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pestchanker%2C+Claudia%22">Pestchanker, Claudia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vrech%2C+Carlos%22">Vrech, Carlos</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tavolini%2C+Darío%22">Tavolini, Darío</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tkachuk%2C+Verónica%22">Tkachuk, Verónica</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zanga%2C+Gisela%22">Zanga, Gisela</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Marrodan%2C+Mariano%22">Marrodan, Mariano</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ysrraelit%2C+María+Célica%22">Ysrraelit, María Célica</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="DE" term="%22COVID-19+vaccines%22">COVID-19 vaccines</searchLink><br /><searchLink fieldCode="DE" term="%22Breakthrough+infections%22">Breakthrough infections</searchLink><br /><searchLink fieldCode="DE" term="%22COVID-19%22">COVID-19</searchLink><br /><searchLink fieldCode="DE" term="%22Multiple+sclerosis%22">Multiple sclerosis</searchLink><br /><searchLink fieldCode="DE" term="%22SARS-CoV-2%22">SARS-CoV-2</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22Argentina%22">Argentina</searchLink>
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  Label: Abstract
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  Data: We aimed to evaluate the incidence of SARS-CoV-2 breakthrough infection of SARS-CoV-2 vaccines in people with MS (PwMS) on high-efficacy disease-modifying therapies (HET) included in the national MS registry in Argentina (RelevarEM). Methods: Non-interventional, retrospective cohort study that collected information directly from RelevarEM. Adult PwMS who had been treated for at least 6 months with a HET (ocrelizumab, natalizumab, alemtuzumab, cladribine) who had received at least two doses of SARS-CoV-2 vaccines available in Argentina were included. Full course of vaccination was considered after the second dose of the corresponding vaccines. Cumulative incidence of SARS-CoV-2 infection was reported for the whole cohort by Kaplan–Meier survival curves (which is expressed in percentage) as well as incidence density (which is expressed per 10.000 patients/day with 95% CI). Results: Two hundred twenty-eight PwMS were included. Most frequent first and second dose received was AstraZeneca vaccine, followed by Sputnik vaccine. Most frequent HETs used in included patients were cladribine in 79 (34.8%). We found an incidence density of breakthrough COVID-19 infection of 3.5 × 10.000 patients/day (95% CI 2.3–6.7) after vaccination in Argentina. We described the incidence rate after vaccination for every HET used, it being significantly higher for ocrelizumab compared with other HETs (p = 0.005). Only five patients presented a relapse during the follow-up period with no differences regarding the pre-vaccination period. Conclusions: We found an incidence density of breakthrough COVID-19 infection of 3.5 × 10.000 patients/day (95% CI 2.3–6.7) after vaccination in Argentina. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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