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Does childhood adversity alter opioid drug reward? A conceptual replication in outpatients before surgery.

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Title: Does childhood adversity alter opioid drug reward? A conceptual replication in outpatients before surgery.
Authors: Carlyle, Molly, Kvande, Malin, Meier, Isabell M., Trøstheim, Martin, Buen, Kaja, Jensen, Eira Nordeng, Ernst, Gernot, Leknes, Siri, Eikemo, Marie
Source: Addiction Research & Theory. Feb2024, Vol. 32 Issue 1, p46-57. 12p.
Subjects: Adverse childhood experiences, Preoperative care, Statistics, Scientific observation, Intravenous therapy, Analysis of variance, Alcoholism, Substance abuse, Multiple regression analysis, Surgery, Patients, Mental health, Oxycodone, Pearson correlation (Statistics), Reward (Psychology), Mental depression, Scale analysis (Psychology), Questionnaires, Social classes, Loneliness, Opioid analgesics, Anxiety, Pain catastrophizing, Data analysis software, Data analysis, Logistic regression analysis, Outpatient services in hospitals, Psychopharmacology
Geographic Terms: Norway
Abstract: Opioid analgesic treatment during surgery entails the risk of persistent use. Experiences of childhood adversity have been shown to increase opioid reward in preclinical models, a finding recently extended to healthy humans. We tested whether childhood adversity similarly increased opioid reward, operationalized as drug-induced feeling good and drug liking, in outpatients receiving opioids on the operating table. This observational study recruited patients entering a Norwegian hospital for an outpatient surgical procedure. An opioid intravenous opioid analgesic (remifentanil [Minto model, effect-site concentration: 5 ng/ml], or oxycodone [5 mg]) was administered in the minutes before general anesthesia. Verbal numerical ratings of feeling good and anxious were collected 1 min before, and 1–3 min after opioid infusion. Ratings of drug liking, disliking, and feelinghigh were also collected after infusion. Patients (n = 151) completed measures of childhood adversity at a later date. Regression analyses revealed a modest yet significant negative association between childhood adversity and post-opioid liking (b = −0.06, p = 0.046) but no significant effect on feeling good (b = 0.01, p = 0.690) after the pre-operative opioid dose. Exploratory analyses showed that more childhood adversity was significantly associated with higher reports of anxiety, depression, loneliness, and pain catastrophising, however not with alcohol or other drug use, or with any other subjective drug effects. Ratings of feeling good and drug liking of medically prescribed opioids given before surgery were not higher after childhood adversity, and previous findings were not conceptually replicated. The discrepancy between current and prior results may be due to the context and stress related to the impending surgery, the short duration of drug exposure, and the relatively limited levels of high childhood adversity in the current sample compared to the original study. Exploratory analysis was consistent with the possibility of a nonlinear relationship between positive opioid effects and childhood adversity scores. Future research should assess the link between childhood adversity, subjective effects, and use of the prescribed opioids after surgery. [ABSTRACT FROM AUTHOR]
Copyright of Addiction Research & Theory is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Does childhood adversity alter opioid drug reward? A conceptual replication in outpatients before surgery.
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  Data: <searchLink fieldCode="JN" term="%22Addiction+Research+%26+Theory%22">Addiction Research & Theory</searchLink>. Feb2024, Vol. 32 Issue 1, p46-57. 12p.
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  Data: Opioid analgesic treatment during surgery entails the risk of persistent use. Experiences of childhood adversity have been shown to increase opioid reward in preclinical models, a finding recently extended to healthy humans. We tested whether childhood adversity similarly increased opioid reward, operationalized as drug-induced feeling good and drug liking, in outpatients receiving opioids on the operating table. This observational study recruited patients entering a Norwegian hospital for an outpatient surgical procedure. An opioid intravenous opioid analgesic (remifentanil [Minto model, effect-site concentration: 5 ng/ml], or oxycodone [5 mg]) was administered in the minutes before general anesthesia. Verbal numerical ratings of feeling good and anxious were collected 1 min before, and 1–3 min after opioid infusion. Ratings of drug liking, disliking, and feelinghigh were also collected after infusion. Patients (n = 151) completed measures of childhood adversity at a later date. Regression analyses revealed a modest yet significant negative association between childhood adversity and post-opioid liking (b = −0.06, p = 0.046) but no significant effect on feeling good (b = 0.01, p = 0.690) after the pre-operative opioid dose. Exploratory analyses showed that more childhood adversity was significantly associated with higher reports of anxiety, depression, loneliness, and pain catastrophising, however not with alcohol or other drug use, or with any other subjective drug effects. Ratings of feeling good and drug liking of medically prescribed opioids given before surgery were not higher after childhood adversity, and previous findings were not conceptually replicated. The discrepancy between current and prior results may be due to the context and stress related to the impending surgery, the short duration of drug exposure, and the relatively limited levels of high childhood adversity in the current sample compared to the original study. Exploratory analysis was consistent with the possibility of a nonlinear relationship between positive opioid effects and childhood adversity scores. Future research should assess the link between childhood adversity, subjective effects, and use of the prescribed opioids after surgery. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Addiction Research & Theory is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/16066359.2023.2211348
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 12
        StartPage: 46
    Subjects:
      – SubjectFull: Adverse childhood experiences
        Type: general
      – SubjectFull: Preoperative care
        Type: general
      – SubjectFull: Statistics
        Type: general
      – SubjectFull: Scientific observation
        Type: general
      – SubjectFull: Intravenous therapy
        Type: general
      – SubjectFull: Analysis of variance
        Type: general
      – SubjectFull: Alcoholism
        Type: general
      – SubjectFull: Substance abuse
        Type: general
      – SubjectFull: Multiple regression analysis
        Type: general
      – SubjectFull: Surgery
        Type: general
      – SubjectFull: Patients
        Type: general
      – SubjectFull: Mental health
        Type: general
      – SubjectFull: Oxycodone
        Type: general
      – SubjectFull: Pearson correlation (Statistics)
        Type: general
      – SubjectFull: Reward (Psychology)
        Type: general
      – SubjectFull: Mental depression
        Type: general
      – SubjectFull: Scale analysis (Psychology)
        Type: general
      – SubjectFull: Questionnaires
        Type: general
      – SubjectFull: Social classes
        Type: general
      – SubjectFull: Loneliness
        Type: general
      – SubjectFull: Opioid analgesics
        Type: general
      – SubjectFull: Anxiety
        Type: general
      – SubjectFull: Pain catastrophizing
        Type: general
      – SubjectFull: Data analysis software
        Type: general
      – SubjectFull: Data analysis
        Type: general
      – SubjectFull: Logistic regression analysis
        Type: general
      – SubjectFull: Outpatient services in hospitals
        Type: general
      – SubjectFull: Psychopharmacology
        Type: general
      – SubjectFull: Norway
        Type: general
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      – TitleFull: Does childhood adversity alter opioid drug reward? A conceptual replication in outpatients before surgery.
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              Text: Feb2024
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