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Lessons in waste management: Deciphering the dual role of Crustacean Rh1 protein in ammonia and CO2 excretion.

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Title: Lessons in waste management: Deciphering the dual role of Crustacean Rh1 protein in ammonia and CO2 excretion.
Authors: Clifford, Alexander M. (AUTHOR)
Source: Acta Physiologica. Feb2024, Vol. 240 Issue 2, p1-3. 3p.
Subjects: Waste management, Ammonia, Excretion, Crustacea, Renal tubular transport disorders, Proteins, ATP-binding cassette transporters
Abstract: The article in Acta Physiologica explores the dual role of the Crustacean Rh1 protein in ammonia and CO2 excretion in the European green crab. The regulation of ammonia and CO2 is crucial for homeostasis in aquatic organisms, as their accumulation can be detrimental to cellular function. The article discusses the traditional views on NH3/NH4+ transport and the discovery of Rh glycoproteins as ammonia transport facilitators. It also examines the involvement of Rh proteins in CO2 transport and presents the findings of a study on the Crustacean specific isoform Rh1 protein. The study utilizes various techniques to investigate the dual function of Rh1, including cloning, mutagenesis, and expression experiments. The authors demonstrate the transport capacity of Rh1 for both ammonia and CO2 and observe the expression patterns of CmRh1 in the gills of the green crab. The article suggests the existence of subcellular reorganization and a potential sensing mechanism for NH3 and/or NH4+ in response to high environmental ammonia. It also highlights the need for further research to understand the mechanisms of Rh protein-mediated CO2 transport and its universality across different species. Overall, the study contributes to our understanding of Rh glycoproteins and their role in waste management. [Extracted from the article]
Copyright of Acta Physiologica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Lessons in waste management: Deciphering the dual role of Crustacean Rh1 protein in ammonia and CO<subscript>2</subscript> excretion.
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  Data: <searchLink fieldCode="AR" term="%22Clifford%2C+Alexander+M%2E%22">Clifford, Alexander M.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Acta+Physiologica%22">Acta Physiologica</searchLink>. Feb2024, Vol. 240 Issue 2, p1-3. 3p.
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  Data: <searchLink fieldCode="DE" term="%22Waste+management%22">Waste management</searchLink><br /><searchLink fieldCode="DE" term="%22Ammonia%22">Ammonia</searchLink><br /><searchLink fieldCode="DE" term="%22Excretion%22">Excretion</searchLink><br /><searchLink fieldCode="DE" term="%22Crustacea%22">Crustacea</searchLink><br /><searchLink fieldCode="DE" term="%22Renal+tubular+transport+disorders%22">Renal tubular transport disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Proteins%22">Proteins</searchLink><br /><searchLink fieldCode="DE" term="%22ATP-binding+cassette+transporters%22">ATP-binding cassette transporters</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The article in Acta Physiologica explores the dual role of the Crustacean Rh1 protein in ammonia and CO2 excretion in the European green crab. The regulation of ammonia and CO2 is crucial for homeostasis in aquatic organisms, as their accumulation can be detrimental to cellular function. The article discusses the traditional views on NH3/NH4+ transport and the discovery of Rh glycoproteins as ammonia transport facilitators. It also examines the involvement of Rh proteins in CO2 transport and presents the findings of a study on the Crustacean specific isoform Rh1 protein. The study utilizes various techniques to investigate the dual function of Rh1, including cloning, mutagenesis, and expression experiments. The authors demonstrate the transport capacity of Rh1 for both ammonia and CO2 and observe the expression patterns of CmRh1 in the gills of the green crab. The article suggests the existence of subcellular reorganization and a potential sensing mechanism for NH3 and/or NH4+ in response to high environmental ammonia. It also highlights the need for further research to understand the mechanisms of Rh protein-mediated CO2 transport and its universality across different species. Overall, the study contributes to our understanding of Rh glycoproteins and their role in waste management. [Extracted from the article]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of Acta Physiologica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1111/apha.14079
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        Text: English
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      – SubjectFull: Waste management
        Type: general
      – SubjectFull: Ammonia
        Type: general
      – SubjectFull: Excretion
        Type: general
      – SubjectFull: Crustacea
        Type: general
      – SubjectFull: Renal tubular transport disorders
        Type: general
      – SubjectFull: Proteins
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      – SubjectFull: ATP-binding cassette transporters
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      – TitleFull: Lessons in waste management: Deciphering the dual role of Crustacean Rh1 protein in ammonia and CO2 excretion.
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              Text: Feb2024
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              Y: 2024
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