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Epilepsy and the risk of adverse cardiovascular events: A nationwide cohort study.

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Title: Epilepsy and the risk of adverse cardiovascular events: A nationwide cohort study.
Authors: Mayer, Josephine (AUTHOR), Fawzy, Ameenathul M. (AUTHOR), Bisson, Arnaud (AUTHOR), Pasi, Marco (AUTHOR), Bodin, Alexandre (AUTHOR), Vigny, Pascal (AUTHOR), Herbert, Julien (AUTHOR), Marson, Anthony G. (AUTHOR), Lip, Gregory Y. H. (AUTHOR), Fauchier, Laurent (AUTHOR)
Source: European Journal of Neurology. Mar2024, Vol. 31 Issue 3, p1-10. 10p.
Subjects: Epilepsy, Cohort analysis, Cardiovascular diseases risk factors, Ischemic stroke, Public hospitals, People with epilepsy
Abstract: Background and purpose: Epilepsy is associated with higher morbidity and mortality compared to people without epilepsy. We performed a retrospective cross‐sectional and longitudinal cohort study to evaluate cardiovascular comorbidity and incident vascular events in people with epilepsy (PWE). Methods: Data were extracted from the French Hospital National Database. PWE (n = 682,349) who were hospitalized between January 2014 and December 2022 were matched on age, sex, and year of hospitalization with 682,349 patients without epilepsy. Follow‐up was conducted from the date of first hospitalization with epilepsy until the date of each outcome or date of last news in the absence of the outcome. Primary outcome was the incidence of all‐cause death, cardiovascular death, myocardial infarction, hospitalization for heart failure, ischaemic stroke (IS), new onset atrial fibrillation, sustained ventricular tachycardia or fibrillation (VT/VF), and cardiac arrest. Results: A diagnosis of epilepsy was associated with higher numbers of cardiovascular risk factors and adverse cardiovascular events compared to controls. People with epilepsy had a higher incidence of all‐cause death (incidence rate ratio [IRR] = 2.69, 95% confidence interval [CI] = 2.67–2.72), cardiovascular death (IRR = 2.16, 95% CI = 2.11–2.20), heart failure (IRR = 1.26, 95% CI = 1.25–1.28), IS (IRR = 2.08, 95% CI = 2.04–2.13), VT/VF (IRR = 1.10, 95% CI = 1.04–1.16), and cardiac arrest (IRR = 2.12, 95% CI = 2.04–2.20). When accounting for all‐cause death as a competing risk, subdistribution hazard ratios for ischaemic stroke of 1.59 (95% CI = 1.55–1.63) and for cardiac arrest of 1.73 (95% CI = 1.58–1.89) demonstrated higher risk in PWE. Conclusions: The prevalence and incident rates of cardiovascular outcomes were significantly higher in PWE. Targeting cardiovascular health could help reduce excess morbidity and mortality in PWE. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Epilepsy and the risk of adverse cardiovascular events: A nationwide cohort study.
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  Data: <searchLink fieldCode="AR" term="%22Mayer%2C+Josephine%22">Mayer, Josephine</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fawzy%2C+Ameenathul+M%2E%22">Fawzy, Ameenathul M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bisson%2C+Arnaud%22">Bisson, Arnaud</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pasi%2C+Marco%22">Pasi, Marco</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bodin%2C+Alexandre%22">Bodin, Alexandre</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vigny%2C+Pascal%22">Vigny, Pascal</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Herbert%2C+Julien%22">Herbert, Julien</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Marson%2C+Anthony+G%2E%22">Marson, Anthony G.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lip%2C+Gregory+Y%2E+H%2E%22">Lip, Gregory Y. H.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fauchier%2C+Laurent%22">Fauchier, Laurent</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neurology%22">European Journal of Neurology</searchLink>. Mar2024, Vol. 31 Issue 3, p1-10. 10p.
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  Data: <searchLink fieldCode="DE" term="%22Epilepsy%22">Epilepsy</searchLink><br /><searchLink fieldCode="DE" term="%22Cohort+analysis%22">Cohort analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Cardiovascular+diseases+risk+factors%22">Cardiovascular diseases risk factors</searchLink><br /><searchLink fieldCode="DE" term="%22Ischemic+stroke%22">Ischemic stroke</searchLink><br /><searchLink fieldCode="DE" term="%22Public+hospitals%22">Public hospitals</searchLink><br /><searchLink fieldCode="DE" term="%22People+with+epilepsy%22">People with epilepsy</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background and purpose: Epilepsy is associated with higher morbidity and mortality compared to people without epilepsy. We performed a retrospective cross‐sectional and longitudinal cohort study to evaluate cardiovascular comorbidity and incident vascular events in people with epilepsy (PWE). Methods: Data were extracted from the French Hospital National Database. PWE (n = 682,349) who were hospitalized between January 2014 and December 2022 were matched on age, sex, and year of hospitalization with 682,349 patients without epilepsy. Follow‐up was conducted from the date of first hospitalization with epilepsy until the date of each outcome or date of last news in the absence of the outcome. Primary outcome was the incidence of all‐cause death, cardiovascular death, myocardial infarction, hospitalization for heart failure, ischaemic stroke (IS), new onset atrial fibrillation, sustained ventricular tachycardia or fibrillation (VT/VF), and cardiac arrest. Results: A diagnosis of epilepsy was associated with higher numbers of cardiovascular risk factors and adverse cardiovascular events compared to controls. People with epilepsy had a higher incidence of all‐cause death (incidence rate ratio [IRR] = 2.69, 95% confidence interval [CI] = 2.67–2.72), cardiovascular death (IRR = 2.16, 95% CI = 2.11–2.20), heart failure (IRR = 1.26, 95% CI = 1.25–1.28), IS (IRR = 2.08, 95% CI = 2.04–2.13), VT/VF (IRR = 1.10, 95% CI = 1.04–1.16), and cardiac arrest (IRR = 2.12, 95% CI = 2.04–2.20). When accounting for all‐cause death as a competing risk, subdistribution hazard ratios for ischaemic stroke of 1.59 (95% CI = 1.55–1.63) and for cardiac arrest of 1.73 (95% CI = 1.58–1.89) demonstrated higher risk in PWE. Conclusions: The prevalence and incident rates of cardiovascular outcomes were significantly higher in PWE. Targeting cardiovascular health could help reduce excess morbidity and mortality in PWE. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1111/ene.16116
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      – Code: eng
        Text: English
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        PageCount: 10
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    Subjects:
      – SubjectFull: Epilepsy
        Type: general
      – SubjectFull: Cohort analysis
        Type: general
      – SubjectFull: Cardiovascular diseases risk factors
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      – SubjectFull: Ischemic stroke
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      – SubjectFull: Public hospitals
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      – SubjectFull: People with epilepsy
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      – TitleFull: Epilepsy and the risk of adverse cardiovascular events: A nationwide cohort study.
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              Text: Mar2024
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