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Frontotemporal-spectrum disorders and functional independence in non-demented ALS patients.

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Title: Frontotemporal-spectrum disorders and functional independence in non-demented ALS patients.
Authors: Aiello, Edoardo Nicolò (AUTHOR), Solca, Federica (AUTHOR), Torre, Silvia (AUTHOR), Gentile, Francesco (AUTHOR), Scheveger, Francesco (AUTHOR), Olivero, Marco (AUTHOR), Colombo, Eleonora (AUTHOR), Maranzano, Alessio (AUTHOR), Manzoni, Martina (AUTHOR), Morelli, Claudia (AUTHOR), Doretti, Alberto (AUTHOR), Verde, Federico (AUTHOR), Silani, Vincenzo (AUTHOR), Ticozzi, Nicola (AUTHOR), Poletti, Barbara (AUTHOR)
Source: Neurological Sciences. Mar2024, Vol. 45 Issue 3, p1087-1095. 9p.
Subjects: Amyotrophic lateral sclerosis, Frontotemporal dementia, Activities of daily living, Linguistic change, Apathy, Disease duration
Geographic Terms: Lawton (Okla.), Turin (Italy), Milan (Italy)
Abstract: Background: The present study aimed at determining whether, net of motor confounders, neuropsychological features affect functional independence (FI) in activities of daily living (ADLs) in non-demented amyotrophic lateral sclerosis (ALS) patients. Methods: N = 88 ALS patients without frontotemporal dementia were assessed for FI—Katz's Basic ADL Scale (BADL) and Lawton-Brody's Instrumental ADL Scale (IADL)—, cognition—Edinburgh Cognitive and Behavioural ALS Screen (ECAS)—and behaviour—Beaumont Behavioural Inventory and Dimensional Apathy Scale. The association between cognitive and behavioural measures and BADL/IADL scores was assessed by covarying for demographics, anxiety and depression levels, disease duration and motor confounders—i.e. ALS Functional Rating Scale-Revised (ALSFRS-R) scores, progression rate and both King's and Milano-Torino stages. Results: Higher scores on the ECAS-Language were associated with higher IADL scores (p = 0.005), whilst higher apathetic features—as measured by the Dimensional Apathy Scale (DAS)—were inversely related to the BADL (p = 0.003). Whilst IADL scores were related to all ECAS-Language tasks, the DAS-Initiation was the only subscale associated with BADL scores. Patients with abnormal ECAS-Language (p = 0.023) and DAS (p = 0.008) scores were more functionally dependent than those without. Discussion: Among non-motor features, language changes and apathetic features detrimentally affect FI in non-demented ALS patients. [ABSTRACT FROM AUTHOR]
Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Frontotemporal-spectrum disorders and functional independence in non-demented ALS patients.
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  Data: <searchLink fieldCode="AR" term="%22Aiello%2C+Edoardo+Nicolò%22">Aiello, Edoardo Nicolò</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Solca%2C+Federica%22">Solca, Federica</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Torre%2C+Silvia%22">Torre, Silvia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gentile%2C+Francesco%22">Gentile, Francesco</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Scheveger%2C+Francesco%22">Scheveger, Francesco</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Olivero%2C+Marco%22">Olivero, Marco</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Colombo%2C+Eleonora%22">Colombo, Eleonora</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Maranzano%2C+Alessio%22">Maranzano, Alessio</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Manzoni%2C+Martina%22">Manzoni, Martina</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Morelli%2C+Claudia%22">Morelli, Claudia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Doretti%2C+Alberto%22">Doretti, Alberto</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Verde%2C+Federico%22">Verde, Federico</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Silani%2C+Vincenzo%22">Silani, Vincenzo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ticozzi%2C+Nicola%22">Ticozzi, Nicola</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Poletti%2C+Barbara%22">Poletti, Barbara</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. Mar2024, Vol. 45 Issue 3, p1087-1095. 9p.
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  Data: <searchLink fieldCode="DE" term="%22Amyotrophic+lateral+sclerosis%22">Amyotrophic lateral sclerosis</searchLink><br /><searchLink fieldCode="DE" term="%22Frontotemporal+dementia%22">Frontotemporal dementia</searchLink><br /><searchLink fieldCode="DE" term="%22Activities+of+daily+living%22">Activities of daily living</searchLink><br /><searchLink fieldCode="DE" term="%22Linguistic+change%22">Linguistic change</searchLink><br /><searchLink fieldCode="DE" term="%22Apathy%22">Apathy</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+duration%22">Disease duration</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22Lawton+%28Okla%2E%29%22">Lawton (Okla.)</searchLink><br /><searchLink fieldCode="DE" term="%22Turin+%28Italy%29%22">Turin (Italy)</searchLink><br /><searchLink fieldCode="DE" term="%22Milan+%28Italy%29%22">Milan (Italy)</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Background: The present study aimed at determining whether, net of motor confounders, neuropsychological features affect functional independence (FI) in activities of daily living (ADLs) in non-demented amyotrophic lateral sclerosis (ALS) patients. Methods: N = 88 ALS patients without frontotemporal dementia were assessed for FI—Katz's Basic ADL Scale (BADL) and Lawton-Brody's Instrumental ADL Scale (IADL)—, cognition—Edinburgh Cognitive and Behavioural ALS Screen (ECAS)—and behaviour—Beaumont Behavioural Inventory and Dimensional Apathy Scale. The association between cognitive and behavioural measures and BADL/IADL scores was assessed by covarying for demographics, anxiety and depression levels, disease duration and motor confounders—i.e. ALS Functional Rating Scale-Revised (ALSFRS-R) scores, progression rate and both King's and Milano-Torino stages. Results: Higher scores on the ECAS-Language were associated with higher IADL scores (p = 0.005), whilst higher apathetic features—as measured by the Dimensional Apathy Scale (DAS)—were inversely related to the BADL (p = 0.003). Whilst IADL scores were related to all ECAS-Language tasks, the DAS-Initiation was the only subscale associated with BADL scores. Patients with abnormal ECAS-Language (p = 0.023) and DAS (p = 0.008) scores were more functionally dependent than those without. Discussion: Among non-motor features, language changes and apathetic features detrimentally affect FI in non-demented ALS patients. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s10072-023-07074-3
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        Text: English
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        StartPage: 1087
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      – SubjectFull: Amyotrophic lateral sclerosis
        Type: general
      – SubjectFull: Frontotemporal dementia
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              Text: Mar2024
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