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Functional brain network alterations in the co-occurrence of autism spectrum disorder and attention deficit hyperactivity disorder.

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Title: Functional brain network alterations in the co-occurrence of autism spectrum disorder and attention deficit hyperactivity disorder.
Authors: Lin, Qiwen, Shi, Yafei, Huang, Huiyuan, Jiao, Bingqing, Kuang, Changyi, Chen, Jiawen, Rao, Yuyang, Zhu, Yunpeng, Liu, Wenting, Huang, Ruiwang, Lin, Jiabao, Ma, Lijun
Source: European Child & Adolescent Psychiatry. Feb2024, Vol. 33 Issue 2, p369-380. 12p.
Subjects: Diagnosis of autism, Brain mapping, Magnetic resonance imaging, Attention-deficit hyperactivity disorder, Comparative studies, Autism, Descriptive statistics, Research funding, Comorbidity, Disease complications
Abstract: Autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) are two highly prevalent and commonly co-occurring neurodevelopmental disorders. The neural mechanisms underpinning the comorbidity of ASD and ADHD (ASD + ADHD) remain unclear. We focused on the topological organization and functional connectivity of brain networks in ASD + ADHD patients versus ASD patients without ADHD (ASD-only). Resting-state functional magnetic resonance imaging (rs-fMRI) data from 114 ASD and 161 typically developing (TD) individuals were obtained from the Autism Brain Imaging Data Exchange II. The ASD patients comprised 40 ASD + ADHD and 74 ASD-only individuals. We constructed functional brain networks for each group and performed graph-theory and network-based statistic (NBS) analyses. Group differences between ASD + ADHD and ASD-only were analyzed at three levels: nodal, global, and connectivity. At the nodal level, ASD + ADHD exhibited topological disorganization in the temporal and occipital regions, compared with ASD-only. At the global level, ASD + ADHD and ASD-only displayed no significant differences. At the connectivity level, the NBS analysis revealed that ASD + ADHD showed enhanced functional connectivity between the prefrontal and frontoparietal regions, as well as between the orbitofrontal and occipital regions, compared with ASD-only. The hippocampus was the shared region in aberrant functional connectivity patterns in ASD + ADHD and ASD-only compared with TD. These findings suggests that ASD + ADHD displays altered topology and functional connectivity in the brain regions that undertake social cognition, language processing, and sensory processing. [ABSTRACT FROM AUTHOR]
Copyright of European Child & Adolescent Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Functional brain network alterations in the co-occurrence of autism spectrum disorder and attention deficit hyperactivity disorder.
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  Data: <searchLink fieldCode="AR" term="%22Lin%2C+Qiwen%22">Lin, Qiwen</searchLink><br /><searchLink fieldCode="AR" term="%22Shi%2C+Yafei%22">Shi, Yafei</searchLink><br /><searchLink fieldCode="AR" term="%22Huang%2C+Huiyuan%22">Huang, Huiyuan</searchLink><br /><searchLink fieldCode="AR" term="%22Jiao%2C+Bingqing%22">Jiao, Bingqing</searchLink><br /><searchLink fieldCode="AR" term="%22Kuang%2C+Changyi%22">Kuang, Changyi</searchLink><br /><searchLink fieldCode="AR" term="%22Chen%2C+Jiawen%22">Chen, Jiawen</searchLink><br /><searchLink fieldCode="AR" term="%22Rao%2C+Yuyang%22">Rao, Yuyang</searchLink><br /><searchLink fieldCode="AR" term="%22Zhu%2C+Yunpeng%22">Zhu, Yunpeng</searchLink><br /><searchLink fieldCode="AR" term="%22Liu%2C+Wenting%22">Liu, Wenting</searchLink><br /><searchLink fieldCode="AR" term="%22Huang%2C+Ruiwang%22">Huang, Ruiwang</searchLink><br /><searchLink fieldCode="AR" term="%22Lin%2C+Jiabao%22">Lin, Jiabao</searchLink><br /><searchLink fieldCode="AR" term="%22Ma%2C+Lijun%22">Ma, Lijun</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22European+Child+%26+Adolescent+Psychiatry%22">European Child & Adolescent Psychiatry</searchLink>. Feb2024, Vol. 33 Issue 2, p369-380. 12p.
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  Data: Autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) are two highly prevalent and commonly co-occurring neurodevelopmental disorders. The neural mechanisms underpinning the comorbidity of ASD and ADHD (ASD + ADHD) remain unclear. We focused on the topological organization and functional connectivity of brain networks in ASD + ADHD patients versus ASD patients without ADHD (ASD-only). Resting-state functional magnetic resonance imaging (rs-fMRI) data from 114 ASD and 161 typically developing (TD) individuals were obtained from the Autism Brain Imaging Data Exchange II. The ASD patients comprised 40 ASD + ADHD and 74 ASD-only individuals. We constructed functional brain networks for each group and performed graph-theory and network-based statistic (NBS) analyses. Group differences between ASD + ADHD and ASD-only were analyzed at three levels: nodal, global, and connectivity. At the nodal level, ASD + ADHD exhibited topological disorganization in the temporal and occipital regions, compared with ASD-only. At the global level, ASD + ADHD and ASD-only displayed no significant differences. At the connectivity level, the NBS analysis revealed that ASD + ADHD showed enhanced functional connectivity between the prefrontal and frontoparietal regions, as well as between the orbitofrontal and occipital regions, compared with ASD-only. The hippocampus was the shared region in aberrant functional connectivity patterns in ASD + ADHD and ASD-only compared with TD. These findings suggests that ASD + ADHD displays altered topology and functional connectivity in the brain regions that undertake social cognition, language processing, and sensory processing. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of European Child & Adolescent Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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              Text: Feb2024
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