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Brief exposure to enriched environment rapidly shapes the glutamate synapses in the rat brain: A metaplastic fingerprint.

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Title: Brief exposure to enriched environment rapidly shapes the glutamate synapses in the rat brain: A metaplastic fingerprint.
Authors: Pintori, Nicholas (AUTHOR), Piva, Alessandro (AUTHOR), Mottarlini, Francesca (AUTHOR), Díaz, Fernando Castillo (AUTHOR), Maggi, Coralie (AUTHOR), Caffino, Lucia (AUTHOR), Fumagalli, Fabio (AUTHOR), Chiamulera, Cristiano (AUTHOR)
Source: European Journal of Neuroscience. Mar2024, Vol. 59 Issue 5, p982-995. 14p.
Subjects: Electroencephalography, Glutamate receptors, Synapses, Methyl aspartate receptors, Environmental enrichment, Glutamate transporters, AMPA receptors, Cholinergic receptors, Dopamine
Abstract: Environmental enrichment (EE) has been shown to produce beneficial effects in addiction disorders; however, due to its configurational complexity, the underlying mechanisms are not yet fully elucidated. Recent evidence suggests that EE, acting as a metaplastic agent, may affect glutamatergic mechanisms underlying appetitive memory and, in turn, modulate reward‐seeking behaviours: here, we have investigated such a possibility following a brief EE exposure. Adult male Sprague–Dawley rats were exposed to EE for 22 h and the expression of critical elements of the glutamate synapse was measured 2 h after the end of EE in the medial prefrontal cortex (mPFC), nucleus accumbens (NAc) and hippocampus (Hipp) brain areas, which are critical for reward and memory. We focused our investigation on the expression of NMDA and AMPA receptor subunits, their scaffolding proteins SAP102 and SAP97, vesicular and membrane glutamate transporters vGluT1 and GLT‐1, and critical structural components such as proteins involved in morphology and function of glutamatergic synapses, PSD95 and Arc/Arg3.1. Our findings demonstrate that a brief EE exposure induces metaplastic changes in glutamatergic mPFC, NAc and Hipp. Such changes are area‐specific and involve postsynaptic NMDA/AMPA receptor subunit composition, as well as changes in the expression of their main scaffolding proteins, thus influencing the retention of such receptors at synaptic sites. Our data indicate that brief EE exposure is sufficient to dynamically modulate the glutamatergic synapses in mPFC‐NAc‐Hipp circuits, which may modulate rewarding and memory processes. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Brief exposure to enriched environment rapidly shapes the glutamate synapses in the rat brain: A metaplastic fingerprint.
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  Data: <searchLink fieldCode="AR" term="%22Pintori%2C+Nicholas%22">Pintori, Nicholas</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Piva%2C+Alessandro%22">Piva, Alessandro</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mottarlini%2C+Francesca%22">Mottarlini, Francesca</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Díaz%2C+Fernando+Castillo%22">Díaz, Fernando Castillo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Maggi%2C+Coralie%22">Maggi, Coralie</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Caffino%2C+Lucia%22">Caffino, Lucia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fumagalli%2C+Fabio%22">Fumagalli, Fabio</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chiamulera%2C+Cristiano%22">Chiamulera, Cristiano</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Mar2024, Vol. 59 Issue 5, p982-995. 14p.
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  Data: <searchLink fieldCode="DE" term="%22Electroencephalography%22">Electroencephalography</searchLink><br /><searchLink fieldCode="DE" term="%22Glutamate+receptors%22">Glutamate receptors</searchLink><br /><searchLink fieldCode="DE" term="%22Synapses%22">Synapses</searchLink><br /><searchLink fieldCode="DE" term="%22Methyl+aspartate+receptors%22">Methyl aspartate receptors</searchLink><br /><searchLink fieldCode="DE" term="%22Environmental+enrichment%22">Environmental enrichment</searchLink><br /><searchLink fieldCode="DE" term="%22Glutamate+transporters%22">Glutamate transporters</searchLink><br /><searchLink fieldCode="DE" term="%22AMPA+receptors%22">AMPA receptors</searchLink><br /><searchLink fieldCode="DE" term="%22Cholinergic+receptors%22">Cholinergic receptors</searchLink><br /><searchLink fieldCode="DE" term="%22Dopamine%22">Dopamine</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Environmental enrichment (EE) has been shown to produce beneficial effects in addiction disorders; however, due to its configurational complexity, the underlying mechanisms are not yet fully elucidated. Recent evidence suggests that EE, acting as a metaplastic agent, may affect glutamatergic mechanisms underlying appetitive memory and, in turn, modulate reward‐seeking behaviours: here, we have investigated such a possibility following a brief EE exposure. Adult male Sprague–Dawley rats were exposed to EE for 22 h and the expression of critical elements of the glutamate synapse was measured 2 h after the end of EE in the medial prefrontal cortex (mPFC), nucleus accumbens (NAc) and hippocampus (Hipp) brain areas, which are critical for reward and memory. We focused our investigation on the expression of NMDA and AMPA receptor subunits, their scaffolding proteins SAP102 and SAP97, vesicular and membrane glutamate transporters vGluT1 and GLT‐1, and critical structural components such as proteins involved in morphology and function of glutamatergic synapses, PSD95 and Arc/Arg3.1. Our findings demonstrate that a brief EE exposure induces metaplastic changes in glutamatergic mPFC, NAc and Hipp. Such changes are area‐specific and involve postsynaptic NMDA/AMPA receptor subunit composition, as well as changes in the expression of their main scaffolding proteins, thus influencing the retention of such receptors at synaptic sites. Our data indicate that brief EE exposure is sufficient to dynamically modulate the glutamatergic synapses in mPFC‐NAc‐Hipp circuits, which may modulate rewarding and memory processes. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=176077650
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        Value: 10.1111/ejn.16279
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      – Code: eng
        Text: English
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        PageCount: 14
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      – SubjectFull: Electroencephalography
        Type: general
      – SubjectFull: Glutamate receptors
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      – SubjectFull: Synapses
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      – SubjectFull: Methyl aspartate receptors
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      – SubjectFull: Environmental enrichment
        Type: general
      – SubjectFull: Glutamate transporters
        Type: general
      – SubjectFull: AMPA receptors
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      – SubjectFull: Cholinergic receptors
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      – SubjectFull: Dopamine
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      – TitleFull: Brief exposure to enriched environment rapidly shapes the glutamate synapses in the rat brain: A metaplastic fingerprint.
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              Text: Mar2024
              Type: published
              Y: 2024
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