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Comparison of migraine with left‐ versus right‐sided headache: A cross‐sectional study.

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Title: Comparison of migraine with left‐ versus right‐sided headache: A cross‐sectional study.
Authors: Sprouse Blum, Adam S., DaSilva, Lauren A., Greenberg, Michael D., Nissenbaum, Alexander J., Shapiro, Robert E., Littenberg, Benjamin
Source: Headache: The Journal of Head & Face Pain. Mar2024, Vol. 64 Issue 3, p259-265. 7p.
Subjects: Cross-sectional method, Data analysis, Questionnaires, Independent variables, Descriptive statistics, Chi-squared test, Mann Whitney U Test, Statistics, Comparative studies, Confidence intervals, Migraine, Comorbidity, Regression analysis
Abstract: Objective: The goal of this study was to clarify whether clinical differences exist between patients with migraine who experience headache that is typically left‐sided ("left‐migraine") versus right‐sided ("right‐migraine") during attacks. Background: Migraine has been associated with unilateral headache for millennia and remains a supportive trait for the clinical diagnosis of migraine of the International Classification of Headache Disorders. It is currently unknown why headache in migraine is commonly unilateral, and whether headache‐sidedness is associated with other clinical features. Methods: This is a cross‐sectional study comparing left‐ versus right‐migraine using all available intake questionnaires of new patients evaluated at an academic tertiary headache center over a 20‐year period. Eligibility was based on patient written responses indicating the typical location of headache during attacks. In our analyses, the side of headache (left or right) was the predictor variable. The outcomes included various migraine characteristics and psychiatric comorbidities. Results: We identified 6527 patients with migraine, of which 340 met study eligibility criteria. Of these, 48.8% (166/340) had left migraine, and 51.2% (174/340) had right migraine. When comparing patients with left‐ versus right‐migraine, patients with left migraine experienced 3.6 fewer headache‐free days (95% confidence interval [CI] 1.3–5.9; p = 0.002) and 2.4 more severe headache days (95% CI 0.8–4.1; p = 0.004) in the previous 4 weeks. No significant differences in age, sex, handedness, migraine characteristics, or psychiatric comorbidities were identified between the two groups. Conclusions: Patients with migraine with typically left‐sided headache during attacks reported a higher burden of headache frequency and severity than those with typically right‐sided headache during attacks. These findings may have implications for our understanding of migraine pathophysiology, treatment, and clinical trial design. Plain Language Summary: In this study, we wanted to learn if patients with migraine who typically experience left‐sided headache during attacks show differences in migraine features or psychiatric comorbidities compared to patients who typically experience right‐sided headache during attacks. We reviewed the intake questionnaires of all new patients diagnosed with migraine at an academic headache center over the last 20 years. Our main finding was that patients with typically left‐sided headache reported more headache days and more severe headache days than patients with typically right‐sided headache. [ABSTRACT FROM AUTHOR]
Copyright of Headache: The Journal of Head & Face Pain is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Comparison of migraine with left‐ versus right‐sided headache: A cross‐sectional study.
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  Data: <searchLink fieldCode="AR" term="%22Sprouse Blum%2C+Adam+S%2E%22">Sprouse Blum, Adam S.</searchLink><br /><searchLink fieldCode="AR" term="%22DaSilva%2C+Lauren+A%2E%22">DaSilva, Lauren A.</searchLink><br /><searchLink fieldCode="AR" term="%22Greenberg%2C+Michael+D%2E%22">Greenberg, Michael D.</searchLink><br /><searchLink fieldCode="AR" term="%22Nissenbaum%2C+Alexander+J%2E%22">Nissenbaum, Alexander J.</searchLink><br /><searchLink fieldCode="AR" term="%22Shapiro%2C+Robert+E%2E%22">Shapiro, Robert E.</searchLink><br /><searchLink fieldCode="AR" term="%22Littenberg%2C+Benjamin%22">Littenberg, Benjamin</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Headache%3A+The+Journal+of+Head+%26+Face+Pain%22">Headache: The Journal of Head & Face Pain</searchLink>. Mar2024, Vol. 64 Issue 3, p259-265. 7p.
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  Data: <searchLink fieldCode="DE" term="%22Cross-sectional+method%22">Cross-sectional method</searchLink><br /><searchLink fieldCode="DE" term="%22Data+analysis%22">Data analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Questionnaires%22">Questionnaires</searchLink><br /><searchLink fieldCode="DE" term="%22Independent+variables%22">Independent variables</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Chi-squared+test%22">Chi-squared test</searchLink><br /><searchLink fieldCode="DE" term="%22Mann+Whitney+U+Test%22">Mann Whitney U Test</searchLink><br /><searchLink fieldCode="DE" term="%22Statistics%22">Statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Comparative+studies%22">Comparative studies</searchLink><br /><searchLink fieldCode="DE" term="%22Confidence+intervals%22">Confidence intervals</searchLink><br /><searchLink fieldCode="DE" term="%22Migraine%22">Migraine</searchLink><br /><searchLink fieldCode="DE" term="%22Comorbidity%22">Comorbidity</searchLink><br /><searchLink fieldCode="DE" term="%22Regression+analysis%22">Regression analysis</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objective: The goal of this study was to clarify whether clinical differences exist between patients with migraine who experience headache that is typically left‐sided ("left‐migraine") versus right‐sided ("right‐migraine") during attacks. Background: Migraine has been associated with unilateral headache for millennia and remains a supportive trait for the clinical diagnosis of migraine of the International Classification of Headache Disorders. It is currently unknown why headache in migraine is commonly unilateral, and whether headache‐sidedness is associated with other clinical features. Methods: This is a cross‐sectional study comparing left‐ versus right‐migraine using all available intake questionnaires of new patients evaluated at an academic tertiary headache center over a 20‐year period. Eligibility was based on patient written responses indicating the typical location of headache during attacks. In our analyses, the side of headache (left or right) was the predictor variable. The outcomes included various migraine characteristics and psychiatric comorbidities. Results: We identified 6527 patients with migraine, of which 340 met study eligibility criteria. Of these, 48.8% (166/340) had left migraine, and 51.2% (174/340) had right migraine. When comparing patients with left‐ versus right‐migraine, patients with left migraine experienced 3.6 fewer headache‐free days (95% confidence interval [CI] 1.3–5.9; p = 0.002) and 2.4 more severe headache days (95% CI 0.8–4.1; p = 0.004) in the previous 4 weeks. No significant differences in age, sex, handedness, migraine characteristics, or psychiatric comorbidities were identified between the two groups. Conclusions: Patients with migraine with typically left‐sided headache during attacks reported a higher burden of headache frequency and severity than those with typically right‐sided headache during attacks. These findings may have implications for our understanding of migraine pathophysiology, treatment, and clinical trial design. Plain Language Summary: In this study, we wanted to learn if patients with migraine who typically experience left‐sided headache during attacks show differences in migraine features or psychiatric comorbidities compared to patients who typically experience right‐sided headache during attacks. We reviewed the intake questionnaires of all new patients diagnosed with migraine at an academic headache center over the last 20 years. Our main finding was that patients with typically left‐sided headache reported more headache days and more severe headache days than patients with typically right‐sided headache. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Headache: The Journal of Head & Face Pain is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=176145999
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    Identifiers:
      – Type: doi
        Value: 10.1111/head.14689
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 7
        StartPage: 259
    Subjects:
      – SubjectFull: Cross-sectional method
        Type: general
      – SubjectFull: Data analysis
        Type: general
      – SubjectFull: Questionnaires
        Type: general
      – SubjectFull: Independent variables
        Type: general
      – SubjectFull: Descriptive statistics
        Type: general
      – SubjectFull: Chi-squared test
        Type: general
      – SubjectFull: Mann Whitney U Test
        Type: general
      – SubjectFull: Statistics
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      – SubjectFull: Comparative studies
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      – SubjectFull: Confidence intervals
        Type: general
      – SubjectFull: Migraine
        Type: general
      – SubjectFull: Comorbidity
        Type: general
      – SubjectFull: Regression analysis
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      – TitleFull: Comparison of migraine with left‐ versus right‐sided headache: A cross‐sectional study.
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              Text: Mar2024
              Type: published
              Y: 2024
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