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Phasic dopamine signals are reduced in the spontaneously hypertensive rat and increased by methylphenidate.

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Title: Phasic dopamine signals are reduced in the spontaneously hypertensive rat and increased by methylphenidate.
Authors: Li, Yu‐Ting (AUTHOR), Huang, Yi‐Ling (AUTHOR), Chen, Jia‐Jin Jason (AUTHOR), Hyland, Brian Ian (AUTHOR), Wickens, Jeffery R. (AUTHOR)
Source: European Journal of Neuroscience. Apr2024, Vol. 59 Issue 7, p1567-1584. 18p.
Subjects: Dopaminergic neurons, Dopamine, Methylphenidate, Attention-deficit hyperactivity disorder, Reinforcement (Psychology), Dopamine uptake inhibitors, Electric stimulation
Abstract: The spontaneously hypertensive rat (SHR) is a selectively bred animal strain that is frequently used to model attention‐deficit hyperactivity disorder (ADHD) because of certain genetically determined behavioural characteristics. To test the hypothesis that the characteristically altered response to positive reinforcement in SHRs may be due to altered phasic dopamine response to reward, we measured phasic dopamine signals in the SHRs and Sprague Dawley (SD) rats using in vivo fast‐scan cyclic voltammetry. The effects of the dopamine reuptake inhibitor, methylphenidate, on these signals were also studied. Phasic dopamine signals during the pairing of a sensory cue with electrical stimulation of midbrain dopamine neurons were significantly smaller in the SHRs than in the SD rats. Over repeated pairings, the dopamine response to the sensory cue increased, whereas the response to the electrical stimulation of dopamine neurons decreased, similarly in both strains. However, the final amplitude of the response to the sensory cue after pairing was significantly smaller in SHRs than in the SD rats. Methylphenidate increased responses to sensory cues to a significantly greater extent in the SHRs than in the SD rats, due largely to differences in the low dose effect. At a higher dose, methylphenidate increased responses to sensory cues and electrical stimulation similarly in SHRs and SD rats. The smaller dopamine responses may explain the reduced salience of reward‐predicting cues previously reported in the SHR, whereas the action of methylphenidate on the cue response suggests a potential mechanism for the therapeutic effects of low‐dose methylphenidate in ADHD. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Label: Title
  Group: Ti
  Data: Phasic dopamine signals are reduced in the spontaneously hypertensive rat and increased by methylphenidate.
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  Data: <searchLink fieldCode="AR" term="%22Li%2C+Yu‐Ting%22">Li, Yu‐Ting</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Huang%2C+Yi‐Ling%22">Huang, Yi‐Ling</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+Jia‐Jin+Jason%22">Chen, Jia‐Jin Jason</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hyland%2C+Brian+Ian%22">Hyland, Brian Ian</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wickens%2C+Jeffery+R%2E%22">Wickens, Jeffery R.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Apr2024, Vol. 59 Issue 7, p1567-1584. 18p.
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  Data: <searchLink fieldCode="DE" term="%22Dopaminergic+neurons%22">Dopaminergic neurons</searchLink><br /><searchLink fieldCode="DE" term="%22Dopamine%22">Dopamine</searchLink><br /><searchLink fieldCode="DE" term="%22Methylphenidate%22">Methylphenidate</searchLink><br /><searchLink fieldCode="DE" term="%22Attention-deficit+hyperactivity+disorder%22">Attention-deficit hyperactivity disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Reinforcement+%28Psychology%29%22">Reinforcement (Psychology)</searchLink><br /><searchLink fieldCode="DE" term="%22Dopamine+uptake+inhibitors%22">Dopamine uptake inhibitors</searchLink><br /><searchLink fieldCode="DE" term="%22Electric+stimulation%22">Electric stimulation</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: The spontaneously hypertensive rat (SHR) is a selectively bred animal strain that is frequently used to model attention‐deficit hyperactivity disorder (ADHD) because of certain genetically determined behavioural characteristics. To test the hypothesis that the characteristically altered response to positive reinforcement in SHRs may be due to altered phasic dopamine response to reward, we measured phasic dopamine signals in the SHRs and Sprague Dawley (SD) rats using in vivo fast‐scan cyclic voltammetry. The effects of the dopamine reuptake inhibitor, methylphenidate, on these signals were also studied. Phasic dopamine signals during the pairing of a sensory cue with electrical stimulation of midbrain dopamine neurons were significantly smaller in the SHRs than in the SD rats. Over repeated pairings, the dopamine response to the sensory cue increased, whereas the response to the electrical stimulation of dopamine neurons decreased, similarly in both strains. However, the final amplitude of the response to the sensory cue after pairing was significantly smaller in SHRs than in the SD rats. Methylphenidate increased responses to sensory cues to a significantly greater extent in the SHRs than in the SD rats, due largely to differences in the low dose effect. At a higher dose, methylphenidate increased responses to sensory cues and electrical stimulation similarly in SHRs and SD rats. The smaller dopamine responses may explain the reduced salience of reward‐predicting cues previously reported in the SHR, whereas the action of methylphenidate on the cue response suggests a potential mechanism for the therapeutic effects of low‐dose methylphenidate in ADHD. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1111/ejn.16269
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      – Code: eng
        Text: English
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      – SubjectFull: Dopaminergic neurons
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      – SubjectFull: Methylphenidate
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      – SubjectFull: Attention-deficit hyperactivity disorder
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      – SubjectFull: Dopamine uptake inhibitors
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      – SubjectFull: Electric stimulation
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      – TitleFull: Phasic dopamine signals are reduced in the spontaneously hypertensive rat and increased by methylphenidate.
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            NameFull: Li, Yu‐Ting
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            NameFull: Huang, Yi‐Ling
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            NameFull: Hyland, Brian Ian
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              Text: Apr2024
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              Y: 2024
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