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New insights on the potential effect of orexin receptor antagonist suvorexant on Parkinson's disease symptoms.

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Title: New insights on the potential effect of orexin receptor antagonist suvorexant on Parkinson's disease symptoms.
Authors: Al-kuraishy, Hayder M. (AUTHOR), Al-Gareeb, Ali I. (AUTHOR), Alexiou, Athanasios (AUTHOR), Papadakis, Marios (AUTHOR), Saad, Hebatallah M. (AUTHOR), Batiha, Gaber El-Saber (AUTHOR)
Source: Neurological Sciences. May2024, Vol. 45 Issue 5, p2367-2368. 2p.
Subjects: Parkinson's disease, Symptoms, Movement disorders, Sleep duration, Sleep, Neuroleptic malignant syndrome, Sleep disorders
Abstract: This letter discusses the potential effect of the orexin receptor antagonist suvorexant on Parkinson's disease (PD) symptoms. Orexin is a neuropeptide involved in sleep regulation and other functions, and dysregulation of the orexin pathway is associated with the development and progression of PD. The letter suggests that suvorexant, which is approved for the management of sleep disorders, could be effective in treating sleep disorders and non-motor symptoms in PD patients. However, a case report showed that suvorexant use in a PD patient led to severe delirium and nightmares. The authors recommend further clinical trials to evaluate the clinical profile of suvorexant in PD and the efficacy of orexin receptor agonists in preventing PD progression. [Extracted from the article]
Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: New insights on the potential effect of orexin receptor antagonist suvorexant on Parkinson's disease symptoms.
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  Data: <searchLink fieldCode="AR" term="%22Al-kuraishy%2C+Hayder+M%2E%22">Al-kuraishy, Hayder M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Al-Gareeb%2C+Ali+I%2E%22">Al-Gareeb, Ali I.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Alexiou%2C+Athanasios%22">Alexiou, Athanasios</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Papadakis%2C+Marios%22">Papadakis, Marios</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Saad%2C+Hebatallah+M%2E%22">Saad, Hebatallah M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Batiha%2C+Gaber+El-Saber%22">Batiha, Gaber El-Saber</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. May2024, Vol. 45 Issue 5, p2367-2368. 2p.
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  Data: <searchLink fieldCode="DE" term="%22Parkinson's+disease%22">Parkinson's disease</searchLink><br /><searchLink fieldCode="DE" term="%22Symptoms%22">Symptoms</searchLink><br /><searchLink fieldCode="DE" term="%22Movement+disorders%22">Movement disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Sleep+duration%22">Sleep duration</searchLink><br /><searchLink fieldCode="DE" term="%22Sleep%22">Sleep</searchLink><br /><searchLink fieldCode="DE" term="%22Neuroleptic+malignant+syndrome%22">Neuroleptic malignant syndrome</searchLink><br /><searchLink fieldCode="DE" term="%22Sleep+disorders%22">Sleep disorders</searchLink>
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  Data: This letter discusses the potential effect of the orexin receptor antagonist suvorexant on Parkinson's disease (PD) symptoms. Orexin is a neuropeptide involved in sleep regulation and other functions, and dysregulation of the orexin pathway is associated with the development and progression of PD. The letter suggests that suvorexant, which is approved for the management of sleep disorders, could be effective in treating sleep disorders and non-motor symptoms in PD patients. However, a case report showed that suvorexant use in a PD patient led to severe delirium and nightmares. The authors recommend further clinical trials to evaluate the clinical profile of suvorexant in PD and the efficacy of orexin receptor agonists in preventing PD progression. [Extracted from the article]
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  Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1007/s10072-023-07261-2
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        Text: English
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      – SubjectFull: Parkinson's disease
        Type: general
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      – SubjectFull: Movement disorders
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      – SubjectFull: Sleep
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      – SubjectFull: Neuroleptic malignant syndrome
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      – SubjectFull: Sleep disorders
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              Text: May2024
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              Y: 2024
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