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Social motivation in infancy is associated with familial recurrence of ASD.

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Title: Social motivation in infancy is associated with familial recurrence of ASD.
Authors: Marrus, Natasha (AUTHOR), Botteron, Kelly N. (AUTHOR), Hawks, Zoë (AUTHOR), Pruett Jr., John R. (AUTHOR), Elison, Jed T. (AUTHOR), Jackson, Joshua J. (AUTHOR), Markson, Lori (AUTHOR), Eggebrecht, Adam T. (AUTHOR), Burrows, Catherine A. (AUTHOR), Zwaigenbaum, Lonnie (AUTHOR), Dager, Stephen R. (AUTHOR), Estes, Annette M. (AUTHOR), Hazlett, Heather Cody (AUTHOR), Schultz, Robert T. (AUTHOR), Piven, Joseph (AUTHOR), Constantino, John N. (AUTHOR)
Source: Development & Psychopathology. Feb2024, Vol. 36 Issue 1, p101-111. 11p.
Subjects: Autism spectrum disorders, Infants, Psychometrics, Motivation (Psychology)
Abstract: Pre-diagnostic deficits in social motivation are hypothesized to contribute to autism spectrum disorder (ASD), a heritable neurodevelopmental condition. We evaluated psychometric properties of a social motivation index (SMI) using parent-report item-level data from 597 participants in a prospective cohort of infant siblings at high and low familial risk for ASD. We tested whether lower SMI scores at 6, 12, and 24 months were associated with a 24-month ASD diagnosis and whether social motivation's course differed relative to familial ASD liability. The SMI displayed good internal consistency and temporal stability. Children diagnosed with ASD displayed lower mean SMI T-scores at all ages and a decrease in mean T-scores across age. Lower group-level 6-month scores corresponded with higher familial ASD liability. Among high-risk infants, strong decline in SMI T-scores was associated with 10-fold odds of diagnosis. Infant social motivation is quantifiable by parental report, differentiates children with versus without later ASD by age 6 months, and tracks with familial ASD liability, consistent with a diagnostic and susceptibility marker of ASD. Early decrements and decline in social motivation indicate increased likelihood of ASD, highlighting social motivation's importance to risk assessment and clarification of the ontogeny of ASD. [ABSTRACT FROM AUTHOR]
Copyright of Development & Psychopathology is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Social motivation in infancy is associated with familial recurrence of ASD.
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  Data: <searchLink fieldCode="AR" term="%22Marrus%2C+Natasha%22">Marrus, Natasha</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Botteron%2C+Kelly+N%2E%22">Botteron, Kelly N.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hawks%2C+Zoë%22">Hawks, Zoë</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pruett+Jr%2E%2C+John+R%2E%22">Pruett Jr., John R.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Elison%2C+Jed+T%2E%22">Elison, Jed T.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jackson%2C+Joshua+J%2E%22">Jackson, Joshua J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Markson%2C+Lori%22">Markson, Lori</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Eggebrecht%2C+Adam+T%2E%22">Eggebrecht, Adam T.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Burrows%2C+Catherine+A%2E%22">Burrows, Catherine A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zwaigenbaum%2C+Lonnie%22">Zwaigenbaum, Lonnie</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dager%2C+Stephen+R%2E%22">Dager, Stephen R.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Estes%2C+Annette+M%2E%22">Estes, Annette M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hazlett%2C+Heather+Cody%22">Hazlett, Heather Cody</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Schultz%2C+Robert+T%2E%22">Schultz, Robert T.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Piven%2C+Joseph%22">Piven, Joseph</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Constantino%2C+John+N%2E%22">Constantino, John N.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Development+%26+Psychopathology%22">Development & Psychopathology</searchLink>. Feb2024, Vol. 36 Issue 1, p101-111. 11p.
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  Data: <searchLink fieldCode="DE" term="%22Autism+spectrum+disorders%22">Autism spectrum disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Infants%22">Infants</searchLink><br /><searchLink fieldCode="DE" term="%22Psychometrics%22">Psychometrics</searchLink><br /><searchLink fieldCode="DE" term="%22Motivation+%28Psychology%29%22">Motivation (Psychology)</searchLink>
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  Label: Abstract
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  Data: Pre-diagnostic deficits in social motivation are hypothesized to contribute to autism spectrum disorder (ASD), a heritable neurodevelopmental condition. We evaluated psychometric properties of a social motivation index (SMI) using parent-report item-level data from 597 participants in a prospective cohort of infant siblings at high and low familial risk for ASD. We tested whether lower SMI scores at 6, 12, and 24 months were associated with a 24-month ASD diagnosis and whether social motivation's course differed relative to familial ASD liability. The SMI displayed good internal consistency and temporal stability. Children diagnosed with ASD displayed lower mean SMI T-scores at all ages and a decrease in mean T-scores across age. Lower group-level 6-month scores corresponded with higher familial ASD liability. Among high-risk infants, strong decline in SMI T-scores was associated with 10-fold odds of diagnosis. Infant social motivation is quantifiable by parental report, differentiates children with versus without later ASD by age 6 months, and tracks with familial ASD liability, consistent with a diagnostic and susceptibility marker of ASD. Early decrements and decline in social motivation indicate increased likelihood of ASD, highlighting social motivation's importance to risk assessment and clarification of the ontogeny of ASD. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Development & Psychopathology is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1017/S0954579422001006
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      – Code: eng
        Text: English
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      – SubjectFull: Autism spectrum disorders
        Type: general
      – SubjectFull: Infants
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      – SubjectFull: Psychometrics
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      – SubjectFull: Motivation (Psychology)
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      – TitleFull: Social motivation in infancy is associated with familial recurrence of ASD.
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              Text: Feb2024
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