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Difficulties during delivery, brain ventricle enlargement and cognitive impairment in first episode psychosis.

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Title: Difficulties during delivery, brain ventricle enlargement and cognitive impairment in first episode psychosis.
Authors: Costas-Carrera, Ana, Verdolini, Norma, Garcia-Rizo, Clemente, Mezquida, Gisela, Janssen, Joost, Valli, Isabel, Corripio, Iluminada, Sanchez-Torres, Ana M., Bioque, Miquel, Lobo, Antonio, Gonzalez-Pinto, Ana, Rapado-Castro, Marta, Vieta, Eduard, De la Serna, Helena, Mane, Anna, Roldan, Alexandra, Crossley, Nicolas, Penades, Rafael, Cuesta, Manuel J., Parellada, Mara
Source: Psychological Medicine. May2024, Vol. 54 Issue 7, p1339-1349. 11p.
Subjects: Risk assessment, Hydrocephalus, Brain, Magnetic resonance imaging, Cognition disorders, Memory, Psychoses, Pregnancy complications, Comparative studies
Abstract: Background: Patients with a first episode of psychosis (FEP) display clinical, cognitive, and structural brain abnormalities at illness onset. Ventricular enlargement has been identified in schizophrenia since the initial development of neuroimaging techniques. Obstetric abnormalities have been associated with an increased risk of developing psychosis but also with cognitive impairment and brain structure abnormalities. Difficulties during delivery are associated with a higher risk of birth asphyxia leading to brain structural abnormalities, such as ventriculomegaly, which has been related to cognitive disturbances. Methods: We examined differences in ventricular size between 142 FEP patients and 123 healthy control participants using magnetic resonance imaging. Obstetric complications were evaluated using the Lewis–Murray scale. We examined the impact of obstetric difficulties during delivery on ventricle size as well as the possible relationship between ventricle size and cognitive impairment in both groups. Results: FEP patients displayed significantly larger third ventricle size compared with healthy controls. Third ventricle enlargement was associated with diagnosis (higher volume in patients), with difficulties during delivery (higher volume in subjects with difficulties), and was highest in patients with difficulties during delivery. Verbal memory was significantly associated with third ventricle to brain ratio. Conclusions: Our results suggest that difficulties during delivery might be significant contributors to the ventricular enlargement historically described in schizophrenia. Thus, obstetric complications may contribute to the development of psychosis through changes in brain architecture. [ABSTRACT FROM AUTHOR]
Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Difficulties during delivery, brain ventricle enlargement and cognitive impairment in first episode psychosis.
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  Data: <searchLink fieldCode="AR" term="%22Costas-Carrera%2C+Ana%22">Costas-Carrera, Ana</searchLink><br /><searchLink fieldCode="AR" term="%22Verdolini%2C+Norma%22">Verdolini, Norma</searchLink><br /><searchLink fieldCode="AR" term="%22Garcia-Rizo%2C+Clemente%22">Garcia-Rizo, Clemente</searchLink><br /><searchLink fieldCode="AR" term="%22Mezquida%2C+Gisela%22">Mezquida, Gisela</searchLink><br /><searchLink fieldCode="AR" term="%22Janssen%2C+Joost%22">Janssen, Joost</searchLink><br /><searchLink fieldCode="AR" term="%22Valli%2C+Isabel%22">Valli, Isabel</searchLink><br /><searchLink fieldCode="AR" term="%22Corripio%2C+Iluminada%22">Corripio, Iluminada</searchLink><br /><searchLink fieldCode="AR" term="%22Sanchez-Torres%2C+Ana+M%2E%22">Sanchez-Torres, Ana M.</searchLink><br /><searchLink fieldCode="AR" term="%22Bioque%2C+Miquel%22">Bioque, Miquel</searchLink><br /><searchLink fieldCode="AR" term="%22Lobo%2C+Antonio%22">Lobo, Antonio</searchLink><br /><searchLink fieldCode="AR" term="%22Gonzalez-Pinto%2C+Ana%22">Gonzalez-Pinto, Ana</searchLink><br /><searchLink fieldCode="AR" term="%22Rapado-Castro%2C+Marta%22">Rapado-Castro, Marta</searchLink><br /><searchLink fieldCode="AR" term="%22Vieta%2C+Eduard%22">Vieta, Eduard</searchLink><br /><searchLink fieldCode="AR" term="%22De+la+Serna%2C+Helena%22">De la Serna, Helena</searchLink><br /><searchLink fieldCode="AR" term="%22Mane%2C+Anna%22">Mane, Anna</searchLink><br /><searchLink fieldCode="AR" term="%22Roldan%2C+Alexandra%22">Roldan, Alexandra</searchLink><br /><searchLink fieldCode="AR" term="%22Crossley%2C+Nicolas%22">Crossley, Nicolas</searchLink><br /><searchLink fieldCode="AR" term="%22Penades%2C+Rafael%22">Penades, Rafael</searchLink><br /><searchLink fieldCode="AR" term="%22Cuesta%2C+Manuel+J%2E%22">Cuesta, Manuel J.</searchLink><br /><searchLink fieldCode="AR" term="%22Parellada%2C+Mara%22">Parellada, Mara</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Psychological+Medicine%22">Psychological Medicine</searchLink>. May2024, Vol. 54 Issue 7, p1339-1349. 11p.
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  Data: <searchLink fieldCode="DE" term="%22Risk+assessment%22">Risk assessment</searchLink><br /><searchLink fieldCode="DE" term="%22Hydrocephalus%22">Hydrocephalus</searchLink><br /><searchLink fieldCode="DE" term="%22Brain%22">Brain</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Cognition+disorders%22">Cognition disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Memory%22">Memory</searchLink><br /><searchLink fieldCode="DE" term="%22Psychoses%22">Psychoses</searchLink><br /><searchLink fieldCode="DE" term="%22Pregnancy+complications%22">Pregnancy complications</searchLink><br /><searchLink fieldCode="DE" term="%22Comparative+studies%22">Comparative studies</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Background: Patients with a first episode of psychosis (FEP) display clinical, cognitive, and structural brain abnormalities at illness onset. Ventricular enlargement has been identified in schizophrenia since the initial development of neuroimaging techniques. Obstetric abnormalities have been associated with an increased risk of developing psychosis but also with cognitive impairment and brain structure abnormalities. Difficulties during delivery are associated with a higher risk of birth asphyxia leading to brain structural abnormalities, such as ventriculomegaly, which has been related to cognitive disturbances. Methods: We examined differences in ventricular size between 142 FEP patients and 123 healthy control participants using magnetic resonance imaging. Obstetric complications were evaluated using the Lewis–Murray scale. We examined the impact of obstetric difficulties during delivery on ventricle size as well as the possible relationship between ventricle size and cognitive impairment in both groups. Results: FEP patients displayed significantly larger third ventricle size compared with healthy controls. Third ventricle enlargement was associated with diagnosis (higher volume in patients), with difficulties during delivery (higher volume in subjects with difficulties), and was highest in patients with difficulties during delivery. Verbal memory was significantly associated with third ventricle to brain ratio. Conclusions: Our results suggest that difficulties during delivery might be significant contributors to the ventricular enlargement historically described in schizophrenia. Thus, obstetric complications may contribute to the development of psychosis through changes in brain architecture. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1017/S0033291723003185
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        Text: English
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              Text: May2024
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