Effectiveness of an intervention to improve ART adherence among men who have sex with men living with HIV: a randomized controlled trial in three public HIV clinics in Mexico.
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| Title: | Effectiveness of an intervention to improve ART adherence among men who have sex with men living with HIV: a randomized controlled trial in three public HIV clinics in Mexico. |
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| Authors: | Andrade-Romo, Zafiro, La Hera-Fuentes, Gina, Ochoa-Sánchez, Luz Edith, Chavira-Razo, Laura, Aramburo-Muro, Tania, Castro-León, Lorena, Amaya-Tapia, Gerardo, Andrade-Pérez, Jorge Santiago, Bautista-Arredondo, Sergio |
| Source: | AIDS Care. Jun2024, Vol. 36 Issue 6, p816-831. 16p. |
| Subjects: | Alcoholism treatment, Substance abuse treatment, Clinical drug trials, Patient compliance, Self-evaluation, Behavior modification, Viral load, Research funding, Evaluation of human services programs, Statistical sampling, HIV-positive persons, CD4 lymphocyte count, HIV infections, Randomized controlled trials, Descriptive statistics, Men who have sex with men, Longitudinal method, Control groups, Pre-tests & post-tests, Health behavior, Anti-HIV agents, Health promotion, Comparative studies, Mental depression |
| Geographic Terms: | Mexico |
| Abstract: | We conducted a parallel-group randomized controlled trial in three HIV clinics in Mexico to evaluate a user-centred habit-formation intervention to improve ART adherence among MSM living with HIV. We randomized 74 participants to the intervention group and 77 to the control group. We measured adherence at one, four, and ten months through medication possession ratio and self-reported adherence. Additionally, we measured viral load, CD4 cell count, major depression disorder symptoms, and alcohol and substance use disorder at baseline, fourth and tenth months. We found no statistically significant effect on adherence between groups. However, the intervention demonstrated positive results in major depression disorder symptoms (21% vs. 6%, p = 0.008) and substance use disorder (11% vs. 1%, p = 0.018) in the fourth month. The latter is relevant because, in addition to its direct benefit, it might also improve the chances of maintaining adequate adherence in the long term. This trial was retrospectively registered at ClinicalTrials.gov (trial number NCT03410680) on 8 January 2018. Trial registration: ClinicalTrials.gov identifier: NCT03410680. [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | We conducted a parallel-group randomized controlled trial in three HIV clinics in Mexico to evaluate a user-centred habit-formation intervention to improve ART adherence among MSM living with HIV. We randomized 74 participants to the intervention group and 77 to the control group. We measured adherence at one, four, and ten months through medication possession ratio and self-reported adherence. Additionally, we measured viral load, CD4 cell count, major depression disorder symptoms, and alcohol and substance use disorder at baseline, fourth and tenth months. We found no statistically significant effect on adherence between groups. However, the intervention demonstrated positive results in major depression disorder symptoms (21% vs. 6%, p = 0.008) and substance use disorder (11% vs. 1%, p = 0.018) in the fourth month. The latter is relevant because, in addition to its direct benefit, it might also improve the chances of maintaining adequate adherence in the long term. This trial was retrospectively registered at ClinicalTrials.gov (trial number NCT03410680) on 8 January 2018. Trial registration: ClinicalTrials.gov identifier: NCT03410680. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 09540121 |
| DOI: | 10.1080/09540121.2023.2299322 |
