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Cachd1 interacts with Wnt receptors and regulates neuronal asymmetry in the zebrafish brain.

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Title: Cachd1 interacts with Wnt receptors and regulates neuronal asymmetry in the zebrafish brain.
Authors: Powell, Gareth T., Faro, Ana, Zhao, Yuguang, Stickney, Heather, Novellasdemunt, Laura, Henriques, Pedro, Gestri, Gaia, White, Esther Redhouse, Ren, Jingshan, Lu, Weixian, Young, Rodrigo M., Hawkins, Thomas A., Cavodeassi, Florencia, Schwarz, Quenten, Dreosti, Elena, Raible, David W., Li, Vivian S. W., Wright, Gavin J., Jones, E. Yvonne, Wilson, Stephen W.
Source: Science (pre-March 2025). 5/3/2024, Vol. 384 Issue 6695, p573-579. 7p. 5 Diagrams.
Subjects: Brain function localization, Receptor-interacting proteins, Wnt proteins, Membrane proteins, Nervous system, Cerebral dominance
Abstract: Neurons on the left and right sides of the nervous system often show asymmetric properties, but how such differences arise is poorly understood. Genetic screening in zebrafish revealed that loss of function of the transmembrane protein Cachd1 resulted in right-sided habenula neurons adopting left-sided identity. Cachd1 is expressed in neuronal progenitors, functions downstream of asymmetric environmental signals, and influences timing of the normally asymmetric patterns of neurogenesis. Biochemical and structural analyses demonstrated that Cachd1 can bind simultaneously to Lrp6 and Frizzled family Wnt co-receptors. Consistent with this, lrp6 mutant zebrafish lose asymmetry in the habenulae, and epistasis experiments support a role for Cachd1 in modulating Wnt pathway activity in the brain. These studies identify Cachd1 as a conserved Wnt receptor-interacting protein that regulates lateralized neuronal identity in the zebrafish brain. [ABSTRACT FROM AUTHOR]
Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Cachd1 interacts with Wnt receptors and regulates neuronal asymmetry in the zebrafish brain.
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  Data: <searchLink fieldCode="AR" term="%22Powell%2C+Gareth+T%2E%22">Powell, Gareth T.</searchLink><br /><searchLink fieldCode="AR" term="%22Faro%2C+Ana%22">Faro, Ana</searchLink><br /><searchLink fieldCode="AR" term="%22Zhao%2C+Yuguang%22">Zhao, Yuguang</searchLink><br /><searchLink fieldCode="AR" term="%22Stickney%2C+Heather%22">Stickney, Heather</searchLink><br /><searchLink fieldCode="AR" term="%22Novellasdemunt%2C+Laura%22">Novellasdemunt, Laura</searchLink><br /><searchLink fieldCode="AR" term="%22Henriques%2C+Pedro%22">Henriques, Pedro</searchLink><br /><searchLink fieldCode="AR" term="%22Gestri%2C+Gaia%22">Gestri, Gaia</searchLink><br /><searchLink fieldCode="AR" term="%22White%2C+Esther+Redhouse%22">White, Esther Redhouse</searchLink><br /><searchLink fieldCode="AR" term="%22Ren%2C+Jingshan%22">Ren, Jingshan</searchLink><br /><searchLink fieldCode="AR" term="%22Lu%2C+Weixian%22">Lu, Weixian</searchLink><br /><searchLink fieldCode="AR" term="%22Young%2C+Rodrigo+M%2E%22">Young, Rodrigo M.</searchLink><br /><searchLink fieldCode="AR" term="%22Hawkins%2C+Thomas+A%2E%22">Hawkins, Thomas A.</searchLink><br /><searchLink fieldCode="AR" term="%22Cavodeassi%2C+Florencia%22">Cavodeassi, Florencia</searchLink><br /><searchLink fieldCode="AR" term="%22Schwarz%2C+Quenten%22">Schwarz, Quenten</searchLink><br /><searchLink fieldCode="AR" term="%22Dreosti%2C+Elena%22">Dreosti, Elena</searchLink><br /><searchLink fieldCode="AR" term="%22Raible%2C+David+W%2E%22">Raible, David W.</searchLink><br /><searchLink fieldCode="AR" term="%22Li%2C+Vivian+S%2E+W%2E%22">Li, Vivian S. W.</searchLink><br /><searchLink fieldCode="AR" term="%22Wright%2C+Gavin+J%2E%22">Wright, Gavin J.</searchLink><br /><searchLink fieldCode="AR" term="%22Jones%2C+E%2E+Yvonne%22">Jones, E. Yvonne</searchLink><br /><searchLink fieldCode="AR" term="%22Wilson%2C+Stephen+W%2E%22">Wilson, Stephen W.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 5/3/2024, Vol. 384 Issue 6695, p573-579. 7p. 5 Diagrams.
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  Data: <searchLink fieldCode="DE" term="%22Brain+function+localization%22">Brain function localization</searchLink><br /><searchLink fieldCode="DE" term="%22Receptor-interacting+proteins%22">Receptor-interacting proteins</searchLink><br /><searchLink fieldCode="DE" term="%22Wnt+proteins%22">Wnt proteins</searchLink><br /><searchLink fieldCode="DE" term="%22Membrane+proteins%22">Membrane proteins</searchLink><br /><searchLink fieldCode="DE" term="%22Nervous+system%22">Nervous system</searchLink><br /><searchLink fieldCode="DE" term="%22Cerebral+dominance%22">Cerebral dominance</searchLink>
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  Label: Abstract
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  Data: Neurons on the left and right sides of the nervous system often show asymmetric properties, but how such differences arise is poorly understood. Genetic screening in zebrafish revealed that loss of function of the transmembrane protein Cachd1 resulted in right-sided habenula neurons adopting left-sided identity. Cachd1 is expressed in neuronal progenitors, functions downstream of asymmetric environmental signals, and influences timing of the normally asymmetric patterns of neurogenesis. Biochemical and structural analyses demonstrated that Cachd1 can bind simultaneously to Lrp6 and Frizzled family Wnt co-receptors. Consistent with this, lrp6 mutant zebrafish lose asymmetry in the habenulae, and epistasis experiments support a role for Cachd1 in modulating Wnt pathway activity in the brain. These studies identify Cachd1 as a conserved Wnt receptor-interacting protein that regulates lateralized neuronal identity in the zebrafish brain. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=177022591
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        Value: 10.1126/science.ade6970
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      – Code: eng
        Text: English
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      – SubjectFull: Receptor-interacting proteins
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      – SubjectFull: Wnt proteins
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      – SubjectFull: Cerebral dominance
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      – TitleFull: Cachd1 interacts with Wnt receptors and regulates neuronal asymmetry in the zebrafish brain.
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              Text: 5/3/2024
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