View in EDS HTML Full Text PDF Full Text

Atypical brain responses to 40‐Hz click trains in girls with Rett syndrome: Auditory steady‐state response and sustained wave.

Saved in:
Bibliographic Details
Title: Atypical brain responses to 40‐Hz click trains in girls with Rett syndrome: Auditory steady‐state response and sustained wave.
Authors: Neklyudova, Anastasia (AUTHOR), Kuramagomedova, Rabiat (AUTHOR), Voinova, Victoria (AUTHOR), Sysoeva, Olga (AUTHOR)
Source: Psychiatry & Clinical Neurosciences. May2024, Vol. 78 Issue 5, p282-290. 9p.
Subjects: Auditory evoked response, Rett syndrome, Acoustic stimulation, Auditory perception, Interstimulus interval, Girls
Abstract: Aim: The current study aimed to infer neurophysiological mechanisms of auditory processing in children with Rett syndrome (RTT)—rare neurodevelopmental disorders caused by MECP2 mutations. We examined two brain responses elicited by 40‐Hz click trains: auditory steady‐state response (ASSR), which reflects fine temporal analysis of auditory input, and sustained wave (SW), which is associated with integral processing of the auditory signal. Methods: We recorded electroencephalogram findings in 43 patients with RTT (aged 2.92–17.1 years) and 43 typically developing children of the same age during 40‐Hz click train auditory stimulation, which lasted for 500 ms and was presented with interstimulus intervals of 500 to 800 ms. Mixed‐model ancova with age as a covariate was used to compare amplitude of ASSR and SW between groups, taking into account the temporal dynamics and topography of the responses. Results: Amplitude of SW was atypically small in children with RTT starting from early childhood, with the difference from typically developing children decreasing with age. ASSR showed a different pattern of developmental changes: the between‐group difference was negligible in early childhood but increased with age as ASSR increased in the typically developing group, but not in those with RTT. Moreover, ASSR was associated with expressive speech development in patients, so that children who could use words had more pronounced ASSR. Conclusion: ASSR and SW show promise as noninvasive electrophysiological biomarkers of auditory processing that have clinical relevance and can shed light onto the link between genetic impairment and the RTT phenotype. [ABSTRACT FROM AUTHOR]
Copyright of Psychiatry & Clinical Neurosciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 177040679
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Atypical brain responses to 40‐Hz click trains in girls with Rett syndrome: Auditory steady‐state response and sustained wave.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Neklyudova%2C+Anastasia%22">Neklyudova, Anastasia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kuramagomedova%2C+Rabiat%22">Kuramagomedova, Rabiat</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Voinova%2C+Victoria%22">Voinova, Victoria</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sysoeva%2C+Olga%22">Sysoeva, Olga</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Psychiatry+%26+Clinical+Neurosciences%22">Psychiatry & Clinical Neurosciences</searchLink>. May2024, Vol. 78 Issue 5, p282-290. 9p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Auditory+evoked+response%22">Auditory evoked response</searchLink><br /><searchLink fieldCode="DE" term="%22Rett+syndrome%22">Rett syndrome</searchLink><br /><searchLink fieldCode="DE" term="%22Acoustic+stimulation%22">Acoustic stimulation</searchLink><br /><searchLink fieldCode="DE" term="%22Auditory+perception%22">Auditory perception</searchLink><br /><searchLink fieldCode="DE" term="%22Interstimulus+interval%22">Interstimulus interval</searchLink><br /><searchLink fieldCode="DE" term="%22Girls%22">Girls</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Aim: The current study aimed to infer neurophysiological mechanisms of auditory processing in children with Rett syndrome (RTT)—rare neurodevelopmental disorders caused by MECP2 mutations. We examined two brain responses elicited by 40‐Hz click trains: auditory steady‐state response (ASSR), which reflects fine temporal analysis of auditory input, and sustained wave (SW), which is associated with integral processing of the auditory signal. Methods: We recorded electroencephalogram findings in 43 patients with RTT (aged 2.92–17.1 years) and 43 typically developing children of the same age during 40‐Hz click train auditory stimulation, which lasted for 500 ms and was presented with interstimulus intervals of 500 to 800 ms. Mixed‐model ancova with age as a covariate was used to compare amplitude of ASSR and SW between groups, taking into account the temporal dynamics and topography of the responses. Results: Amplitude of SW was atypically small in children with RTT starting from early childhood, with the difference from typically developing children decreasing with age. ASSR showed a different pattern of developmental changes: the between‐group difference was negligible in early childhood but increased with age as ASSR increased in the typically developing group, but not in those with RTT. Moreover, ASSR was associated with expressive speech development in patients, so that children who could use words had more pronounced ASSR. Conclusion: ASSR and SW show promise as noninvasive electrophysiological biomarkers of auditory processing that have clinical relevance and can shed light onto the link between genetic impairment and the RTT phenotype. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Psychiatry & Clinical Neurosciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=177040679
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/pcn.13638
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 9
        StartPage: 282
    Subjects:
      – SubjectFull: Auditory evoked response
        Type: general
      – SubjectFull: Rett syndrome
        Type: general
      – SubjectFull: Acoustic stimulation
        Type: general
      – SubjectFull: Auditory perception
        Type: general
      – SubjectFull: Interstimulus interval
        Type: general
      – SubjectFull: Girls
        Type: general
    Titles:
      – TitleFull: Atypical brain responses to 40‐Hz click trains in girls with Rett syndrome: Auditory steady‐state response and sustained wave.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Neklyudova, Anastasia
      – PersonEntity:
          Name:
            NameFull: Kuramagomedova, Rabiat
      – PersonEntity:
          Name:
            NameFull: Voinova, Victoria
      – PersonEntity:
          Name:
            NameFull: Sysoeva, Olga
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 05
              Text: May2024
              Type: published
              Y: 2024
          Identifiers:
            – Type: issn-print
              Value: 13231316
          Numbering:
            – Type: volume
              Value: 78
            – Type: issue
              Value: 5
          Titles:
            – TitleFull: Psychiatry & Clinical Neurosciences
              Type: main
ResultId 1