Bridging gaps in brain disconnection in childhood ADHD: From macroscale connectomes to microscale biological architectures.
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| Title: | Bridging gaps in brain disconnection in childhood ADHD: From macroscale connectomes to microscale biological architectures. |
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| Authors: | Chen, Boxuan (AUTHOR), Qin, Shaozheng (AUTHOR) |
| Source: | Psychiatry & Clinical Neurosciences. May2024, Vol. 78 Issue 5, p271-272. 2p. |
| Subjects: | Attention-deficit hyperactivity disorder |
| Abstract: | This article discusses the neuropathological mechanisms underlying childhood ADHD, focusing on the connection between macroscopic brain connectome aberrations and microscopic biological architectures. The study used neuroimaging data to examine functional connectivity in ADHD children and found perturbations in cortical gradients compared to typically developing peers. These gradient perturbations were associated with neurotransmitter receptors and genetic transcriptional expressions linked to episodic memory and emotional regulation. The article suggests further research into the specific mechanisms underlying brain connectome aberrations in ADHD and the developmental trajectories of these abnormalities. Early detection and interventions are important for managing ADHD and reducing its impact. [Extracted from the article] |
| Copyright of Psychiatry & Clinical Neurosciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | This article discusses the neuropathological mechanisms underlying childhood ADHD, focusing on the connection between macroscopic brain connectome aberrations and microscopic biological architectures. The study used neuroimaging data to examine functional connectivity in ADHD children and found perturbations in cortical gradients compared to typically developing peers. These gradient perturbations were associated with neurotransmitter receptors and genetic transcriptional expressions linked to episodic memory and emotional regulation. The article suggests further research into the specific mechanisms underlying brain connectome aberrations in ADHD and the developmental trajectories of these abnormalities. Early detection and interventions are important for managing ADHD and reducing its impact. [Extracted from the article] |
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| ISSN: | 13231316 |
| DOI: | 10.1111/pcn.13662 |
