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Validating the usefulness of Sudoscan in ATTRv: a single centre experience.

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Title: Validating the usefulness of Sudoscan in ATTRv: a single centre experience.
Authors: Moreno-Moraleda, Elena (AUTHOR), González-Moreno, Juan (AUTHOR), Cisneros-Barroso, Eugenia (AUTHOR), Ribot-Sansó, María Antonia (AUTHOR), Ripoll-Vera, Tomás (AUTHOR), Descals, Cristina (AUTHOR), Uson, Mercedes (AUTHOR), Montalà, Joan Carles (AUTHOR), Figuerola, Antoni (AUTHOR), Rodríguez, Adrián (AUTHOR), Losada, Inés (AUTHOR)
Source: Neurological Sciences. Jun2024, Vol. 45 Issue 6, p2859-2867. 9p.
Subjects: Median (Mathematics), Asymptomatic patients, Receiver operating characteristic curves, Kruskal-Wallis Test, Sensitivity & specificity (Statistics)
Abstract: Background: Variant transthyretin amyloidosis (ATTRv) can cause sensorimotor and autonomic neuropathy. Objective quantification of sudomotor function may be essential for early diagnosis and early initiation of treatment. The aim of this study is to evaluate the diagnostic value of the Sudoscan® in ATTRv. Methods: Electrochemical skin conductance (ESC) was measured in V30M ATTRv patients, asymtomatic V30M carriers and healthy controls. Comparisons between the three groups were made using the Kruskal-Wallis test, and ROC curves were used to estimate the discriminatory power of ESC values between groups. Results: ESC was measured in 52 ATTRv patients, 107 asymptomatic carriers and 40 healthy controls. ESC was significantly lower in ATTRv patients compared to asymptomatic carriers and healthy controls in both feet and hands; median values are as follows: 40 µS, 78 µS and 81 µS, respectively (p < 0.001), and 53 µS, 69 µS and 74 µS, respectively (p < 0.001). ESC in feet < 70.5 µS had a sensitivity of 89.7% and specificity of 84.6% to discriminate asymptomatic carriers from patients with ATTRv. Conclusion: The determination of ESC by Sudoscan® is a rapid, noninvasive and easily reproducible technique capable of discriminating patients with ATTRv from asymptomatic carriers and healthy controls with adequate sensitivity and specificity. [ABSTRACT FROM AUTHOR]
Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Validating the usefulness of Sudoscan in ATTRv: a single centre experience.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Moreno-Moraleda%2C+Elena%22&quot;&gt;Moreno-Moraleda, Elena&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Gonz&#225;lez-Moreno%2C+Juan%22&quot;&gt;Gonz&#225;lez-Moreno, Juan&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Cisneros-Barroso%2C+Eugenia%22&quot;&gt;Cisneros-Barroso, Eugenia&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Ribot-Sans&#243;%2C+Mar&#237;a+Antonia%22&quot;&gt;Ribot-Sans&#243;, Mar&#237;a Antonia&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Ripoll-Vera%2C+Tom&#225;s%22&quot;&gt;Ripoll-Vera, Tom&#225;s&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Descals%2C+Cristina%22&quot;&gt;Descals, Cristina&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Uson%2C+Mercedes%22&quot;&gt;Uson, Mercedes&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Montal&#224;%2C+Joan+Carles%22&quot;&gt;Montal&#224;, Joan Carles&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Figuerola%2C+Antoni%22&quot;&gt;Figuerola, Antoni&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Rodr&#237;guez%2C+Adri&#225;n%22&quot;&gt;Rodr&#237;guez, Adri&#225;n&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Losada%2C+In&#233;s%22&quot;&gt;Losada, In&#233;s&lt;/searchLink&gt; (AUTHOR)
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Neurological+Sciences%22&quot;&gt;Neurological Sciences&lt;/searchLink&gt;. Jun2024, Vol. 45 Issue 6, p2859-2867. 9p.
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  Data: Background: Variant transthyretin amyloidosis (ATTRv) can cause sensorimotor and autonomic neuropathy. Objective quantification of sudomotor function may be essential for early diagnosis and early initiation of treatment. The aim of this study is to evaluate the diagnostic value of the Sudoscan&#174; in ATTRv. Methods: Electrochemical skin conductance (ESC) was measured in V30M ATTRv patients, asymtomatic V30M carriers and healthy controls. Comparisons between the three groups were made using the Kruskal-Wallis test, and ROC curves were used to estimate the discriminatory power of ESC values between groups. Results: ESC was measured in 52 ATTRv patients, 107 asymptomatic carriers and 40 healthy controls. ESC was significantly lower in ATTRv patients compared to asymptomatic carriers and healthy controls in both feet and hands; median values are as follows: 40 &#181;S, 78 &#181;S and 81 &#181;S, respectively (p &lt; 0.001), and 53 &#181;S, 69 &#181;S and 74 &#181;S, respectively (p &lt; 0.001). ESC in feet &lt; 70.5 &#181;S had a sensitivity of 89.7% and specificity of 84.6% to discriminate asymptomatic carriers from patients with ATTRv. Conclusion: The determination of ESC by Sudoscan&#174; is a rapid, noninvasive and easily reproducible technique capable of discriminating patients with ATTRv from asymptomatic carriers and healthy controls with adequate sensitivity and specificity. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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