View in EDS

Assessing the contribution of the chemical exposome to neurodegenerative disease.

Saved in:
Bibliographic Details
Title: Assessing the contribution of the chemical exposome to neurodegenerative disease.
Authors: Lefèvre-Arbogast, S. (AUTHOR), Chaker, J. (AUTHOR), Mercier, F. (AUTHOR), Barouki, R. (AUTHOR), Coumoul, X. (AUTHOR), Miller, G. W. (AUTHOR), David, A. (AUTHOR), Samieri, C. (AUTHOR)
Source: Nature Neuroscience. May2024, Vol. 27 Issue 5, p812-821. 10p.
Abstract: Over the past few decades, numerous environmental chemicals from solvents to pesticides have been suggested to be involved in the development and progression of neurodegenerative diseases. Most of the evidence has accumulated from occupational or cohort studies in humans or laboratory research in animal models, with a range of chemicals being implicated. What has been missing is a systematic approach analogous to genome-wide association studies, which have identified dozens of genes involved in Alzheimer's disease, Parkinson's disease and other neurodegenerative diseases. Fortunately, it is now possible to study hundreds to thousands of chemical features under the exposome framework. This Perspective explores how advances in mass spectrometry make it possible to generate exposomic data to complement genomic data and thereby better understand neurodegenerative diseases. Nongenetic factors contribute to the onset, progression and severity of neurodegenerative diseases. Here, the authors describe how exposomics, the systematic analysis of environmental factors, can help neuroscientists understand these diseases. [ABSTRACT FROM AUTHOR]
Copyright of Nature Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 177190310
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Assessing the contribution of the chemical exposome to neurodegenerative disease.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Lefèvre-Arbogast%2C+S%2E%22">Lefèvre-Arbogast, S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chaker%2C+J%2E%22">Chaker, J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mercier%2C+F%2E%22">Mercier, F.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Barouki%2C+R%2E%22">Barouki, R.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Coumoul%2C+X%2E%22">Coumoul, X.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Miller%2C+G%2E+W%2E%22">Miller, G. W.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22David%2C+A%2E%22">David, A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Samieri%2C+C%2E%22">Samieri, C.</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Nature+Neuroscience%22">Nature Neuroscience</searchLink>. May2024, Vol. 27 Issue 5, p812-821. 10p.
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Over the past few decades, numerous environmental chemicals from solvents to pesticides have been suggested to be involved in the development and progression of neurodegenerative diseases. Most of the evidence has accumulated from occupational or cohort studies in humans or laboratory research in animal models, with a range of chemicals being implicated. What has been missing is a systematic approach analogous to genome-wide association studies, which have identified dozens of genes involved in Alzheimer's disease, Parkinson's disease and other neurodegenerative diseases. Fortunately, it is now possible to study hundreds to thousands of chemical features under the exposome framework. This Perspective explores how advances in mass spectrometry make it possible to generate exposomic data to complement genomic data and thereby better understand neurodegenerative diseases. Nongenetic factors contribute to the onset, progression and severity of neurodegenerative diseases. Here, the authors describe how exposomics, the systematic analysis of environmental factors, can help neuroscientists understand these diseases. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Nature Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=177190310
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1038/s41593-024-01627-1
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 10
        StartPage: 812
    Titles:
      – TitleFull: Assessing the contribution of the chemical exposome to neurodegenerative disease.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Lefèvre-Arbogast, S.
      – PersonEntity:
          Name:
            NameFull: Chaker, J.
      – PersonEntity:
          Name:
            NameFull: Mercier, F.
      – PersonEntity:
          Name:
            NameFull: Barouki, R.
      – PersonEntity:
          Name:
            NameFull: Coumoul, X.
      – PersonEntity:
          Name:
            NameFull: Miller, G. W.
      – PersonEntity:
          Name:
            NameFull: David, A.
      – PersonEntity:
          Name:
            NameFull: Samieri, C.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 05
              Text: May2024
              Type: published
              Y: 2024
          Identifiers:
            – Type: issn-print
              Value: 10976256
          Numbering:
            – Type: volume
              Value: 27
            – Type: issue
              Value: 5
          Titles:
            – TitleFull: Nature Neuroscience
              Type: main
ResultId 1