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Repeated Δ-9-Tetrahydrocannabinol administration dose dependently increases stablished schedule-induced drinking.

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Title: Repeated Δ-9-Tetrahydrocannabinol administration dose dependently increases stablished schedule-induced drinking.
Authors: Fuentes-Verdugo, Esmeralda (AUTHOR), Pellón, Ricardo (AUTHOR), Miguéns, Miguel (AUTHOR)
Source: Psychopharmacology. Jun2024, Vol. 241 Issue 6, p1277-1286. 10p.
Subjects: Tetrahydrocannabinol, Animal behavior, Local delivery services, Obsessive-compulsive disorder, Laboratory rats, Operant behavior, Medical marijuana, Interstimulus interval
Abstract: Rationale: Schedule-induced drinking (SID) reproduces an excessive and repetitive behavioural pattern that has led to propose this procedure as an animal model to study compulsive behaviours. Although it is known that cannabis can cause several adverse effects, in recent years there has been great interest in the medical application of cannabis derivatives for obsessive-compulsive related disorders. Objectives: The present study investigated the effects of repeated THC administration on rates of previously acquired SID, as well as the possible alteration of its temporal distribution along inter-food intervals. Methods: Male Wistar rats acquired SID under a 30 min fixed-time 30-sec food delivery schedule (from 30 to 43 sessions to reach a stable level). Thereafter, 5 or 10 mg/kg daily i.p. injections of THC or vehicle were repeatedly administered for 7 days to evaluate the effects on SID. Results: Repeated THC administration at a dose of 5 mg/kg resulted in an increase on licking. Surprisingly, no effects on SID were observed with the 10 mg/kg dose. However, magazine entries were reduced with both THC doses. THC also modified the temporal distributions of licking and magazine entries during inter-food intervals. Conclusions: The present results show that repeated THC administration may (i) increase induced licking at moderate doses, (ii) reduce magazine entries, and (iii) affect the temporal pattern of SID. These findings suggest that THC does not appear to be beneficial to reduce compulsive behaviour in this animal model, while another collateral effect of THC —such as a greater habitual-like behaviour— needs to be considered. [ABSTRACT FROM AUTHOR]
Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Label: Title
  Group: Ti
  Data: Repeated Δ-9-Tetrahydrocannabinol administration dose dependently increases stablished schedule-induced drinking.
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  Data: <searchLink fieldCode="AR" term="%22Fuentes-Verdugo%2C+Esmeralda%22">Fuentes-Verdugo, Esmeralda</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pellón%2C+Ricardo%22">Pellón, Ricardo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Miguéns%2C+Miguel%22">Miguéns, Miguel</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Psychopharmacology%22">Psychopharmacology</searchLink>. Jun2024, Vol. 241 Issue 6, p1277-1286. 10p.
– Name: Subject
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  Data: <searchLink fieldCode="DE" term="%22Tetrahydrocannabinol%22">Tetrahydrocannabinol</searchLink><br /><searchLink fieldCode="DE" term="%22Animal+behavior%22">Animal behavior</searchLink><br /><searchLink fieldCode="DE" term="%22Local+delivery+services%22">Local delivery services</searchLink><br /><searchLink fieldCode="DE" term="%22Obsessive-compulsive+disorder%22">Obsessive-compulsive disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Laboratory+rats%22">Laboratory rats</searchLink><br /><searchLink fieldCode="DE" term="%22Operant+behavior%22">Operant behavior</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+marijuana%22">Medical marijuana</searchLink><br /><searchLink fieldCode="DE" term="%22Interstimulus+interval%22">Interstimulus interval</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Rationale: Schedule-induced drinking (SID) reproduces an excessive and repetitive behavioural pattern that has led to propose this procedure as an animal model to study compulsive behaviours. Although it is known that cannabis can cause several adverse effects, in recent years there has been great interest in the medical application of cannabis derivatives for obsessive-compulsive related disorders. Objectives: The present study investigated the effects of repeated THC administration on rates of previously acquired SID, as well as the possible alteration of its temporal distribution along inter-food intervals. Methods: Male Wistar rats acquired SID under a 30 min fixed-time 30-sec food delivery schedule (from 30 to 43 sessions to reach a stable level). Thereafter, 5 or 10 mg/kg daily i.p. injections of THC or vehicle were repeatedly administered for 7 days to evaluate the effects on SID. Results: Repeated THC administration at a dose of 5 mg/kg resulted in an increase on licking. Surprisingly, no effects on SID were observed with the 10 mg/kg dose. However, magazine entries were reduced with both THC doses. THC also modified the temporal distributions of licking and magazine entries during inter-food intervals. Conclusions: The present results show that repeated THC administration may (i) increase induced licking at moderate doses, (ii) reduce magazine entries, and (iii) affect the temporal pattern of SID. These findings suggest that THC does not appear to be beneficial to reduce compulsive behaviour in this animal model, while another collateral effect of THC —such as a greater habitual-like behaviour— needs to be considered. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s00213-024-06563-3
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        Text: English
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        Type: general
      – SubjectFull: Animal behavior
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      – SubjectFull: Medical marijuana
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      – SubjectFull: Interstimulus interval
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      – TitleFull: Repeated Δ-9-Tetrahydrocannabinol administration dose dependently increases stablished schedule-induced drinking.
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              Text: Jun2024
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