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Dopamine neuron activity evoked by sucrose and sucrose‐predictive cues is augmented by peripheral and central manipulations of glucose availability.

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Title: Dopamine neuron activity evoked by sucrose and sucrose‐predictive cues is augmented by peripheral and central manipulations of glucose availability.
Authors: Konanur, Vaibhav R. (AUTHOR), Hurh, Samantha J. (AUTHOR), Hsu, Ted M. (AUTHOR), Roitman, Mitchell F. (AUTHOR)
Source: European Journal of Neuroscience. May2024, Vol. 59 Issue 10, p2419-2435. 17p.
Subjects: Dopamine, Glucose, Sucrose, Blood sugar, Hypothalamus, Dopaminergic neurons, Rhombencephalon, Insulin therapy, Brain stem
Abstract: Food deprivation drives eating through multiple signals and circuits. Decreased glucose availability (i.e., cytoglucopenia) drives eating and also increases the value of sucrose. Ventral tegmental area (VTA) dopamine neurons (DANs) contribute to the evaluation of taste stimuli, but their role in integrating glucoprivic signals remains unknown. We monitored VTA DAN activity via Cre‐dependent expression of a calcium indicator with in vivo fibre photometry. In ad libitum fed rats, intraoral sucrose evoked a phasic increase in DAN activity. To manipulate glucose availability, we administered (intraperitoneal, lateral or fourth ventricular) the antiglycolytic agent 5‐thio‐D‐glucose (5TG), which significantly augmented the phasic DAN activity to sucrose. 5TG failed to alter DAN activity to water or saccharin, suggesting the response was selective for caloric stimuli. 5TG enhancement of sucrose‐evoked DAN activity was stronger after fourth ventricular administration, suggesting a critical node of action within the hindbrain. As 5TG also increases blood glucose, in a separate study, we used peripheral insulin, which stimulates eating, to decrease blood glucose—which was associated with increased DAN activity to intraoral sucrose. DAN activity developed to a cue predictive of intraoral sucrose. While 5TG augmented cue‐evoked DAN activity, its action was most potent when delivered to the lateral ventricle. Together, the studies point to central glucose availability as a key modulator of phasic DAN activity to food and food‐cues. As glucose sensing neurons are known to populate the hypothalamus and brainstem, results suggest differential modulation of cue‐evoked and sucrose‐evoked DAN activity. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Label: Title
  Group: Ti
  Data: Dopamine neuron activity evoked by sucrose and sucrose‐predictive cues is augmented by peripheral and central manipulations of glucose availability.
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  Data: <searchLink fieldCode="AR" term="%22Konanur%2C+Vaibhav+R%2E%22">Konanur, Vaibhav R.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hurh%2C+Samantha+J%2E%22">Hurh, Samantha J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hsu%2C+Ted+M%2E%22">Hsu, Ted M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Roitman%2C+Mitchell+F%2E%22">Roitman, Mitchell F.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. May2024, Vol. 59 Issue 10, p2419-2435. 17p.
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  Data: <searchLink fieldCode="DE" term="%22Dopamine%22">Dopamine</searchLink><br /><searchLink fieldCode="DE" term="%22Glucose%22">Glucose</searchLink><br /><searchLink fieldCode="DE" term="%22Sucrose%22">Sucrose</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+sugar%22">Blood sugar</searchLink><br /><searchLink fieldCode="DE" term="%22Hypothalamus%22">Hypothalamus</searchLink><br /><searchLink fieldCode="DE" term="%22Dopaminergic+neurons%22">Dopaminergic neurons</searchLink><br /><searchLink fieldCode="DE" term="%22Rhombencephalon%22">Rhombencephalon</searchLink><br /><searchLink fieldCode="DE" term="%22Insulin+therapy%22">Insulin therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+stem%22">Brain stem</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Food deprivation drives eating through multiple signals and circuits. Decreased glucose availability (i.e., cytoglucopenia) drives eating and also increases the value of sucrose. Ventral tegmental area (VTA) dopamine neurons (DANs) contribute to the evaluation of taste stimuli, but their role in integrating glucoprivic signals remains unknown. We monitored VTA DAN activity via Cre‐dependent expression of a calcium indicator with in vivo fibre photometry. In ad libitum fed rats, intraoral sucrose evoked a phasic increase in DAN activity. To manipulate glucose availability, we administered (intraperitoneal, lateral or fourth ventricular) the antiglycolytic agent 5‐thio‐D‐glucose (5TG), which significantly augmented the phasic DAN activity to sucrose. 5TG failed to alter DAN activity to water or saccharin, suggesting the response was selective for caloric stimuli. 5TG enhancement of sucrose‐evoked DAN activity was stronger after fourth ventricular administration, suggesting a critical node of action within the hindbrain. As 5TG also increases blood glucose, in a separate study, we used peripheral insulin, which stimulates eating, to decrease blood glucose—which was associated with increased DAN activity to intraoral sucrose. DAN activity developed to a cue predictive of intraoral sucrose. While 5TG augmented cue‐evoked DAN activity, its action was most potent when delivered to the lateral ventricle. Together, the studies point to central glucose availability as a key modulator of phasic DAN activity to food and food‐cues. As glucose sensing neurons are known to populate the hypothalamus and brainstem, results suggest differential modulation of cue‐evoked and sucrose‐evoked DAN activity. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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    Identifiers:
      – Type: doi
        Value: 10.1111/ejn.16214
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 17
        StartPage: 2419
    Subjects:
      – SubjectFull: Dopamine
        Type: general
      – SubjectFull: Glucose
        Type: general
      – SubjectFull: Sucrose
        Type: general
      – SubjectFull: Blood sugar
        Type: general
      – SubjectFull: Hypothalamus
        Type: general
      – SubjectFull: Dopaminergic neurons
        Type: general
      – SubjectFull: Rhombencephalon
        Type: general
      – SubjectFull: Insulin therapy
        Type: general
      – SubjectFull: Brain stem
        Type: general
    Titles:
      – TitleFull: Dopamine neuron activity evoked by sucrose and sucrose‐predictive cues is augmented by peripheral and central manipulations of glucose availability.
        Type: main
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            NameFull: Konanur, Vaibhav R.
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            NameFull: Hurh, Samantha J.
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            NameFull: Hsu, Ted M.
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              M: 05
              Text: May2024
              Type: published
              Y: 2024
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              Value: 59
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