Effects of transcutaneous auricular vagus nerve stimulation at left cymba concha on experimental pain as assessed with the nociceptive withdrawal reflex, and correlation with parasympathetic activity.
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| Title: | Effects of transcutaneous auricular vagus nerve stimulation at left cymba concha on experimental pain as assessed with the nociceptive withdrawal reflex, and correlation with parasympathetic activity. |
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| Authors: | Yokota, Hirotake (AUTHOR), Edama, Mutsuaki (AUTHOR), Kawanabe, Yurika (AUTHOR), Hirabayashi, Ryo (AUTHOR), Sekikne, Chie (AUTHOR), Akuzawa, Hiroshi (AUTHOR), Ishigaki, Tomonobu (AUTHOR), Otsuru, Naofumi (AUTHOR), Saito, Kei (AUTHOR), Kojima, Sho (AUTHOR), Miyaguchi, Shota (AUTHOR), Onishi, Hideaki (AUTHOR) |
| Source: | European Journal of Neuroscience. May2024, Vol. 59 Issue 10, p2826-2835. 10p. |
| Subjects: | Vagus nerve stimulation, Parasympathetic nervous system, Reflexes, Vagus nerve, Neural stimulation, Electric stimulation, Heart beat, Biceps femoris |
| Abstract: | The aim of this study was to clarify the effects of transcutaneous auricular vagus nerve stimulation (taVNS) to the left cymba concha on the pain perception using nociceptive withdrawal reflex (NWR), which is known to be associated with chronic pain, and to investigate whether there is a relationship between taVNS‐induced suppression of the NWR and parasympathetic activation. We applied either 3.0 mA, 100 Hz taVNS for 120 s on the left cymba concha (taVNS condition) or the left earlobe (Sham condition) for 20 healthy adults. NWR threshold was measured before (Baseline), immediately after (Post 0), 10 min (Post 10) and 30 min after (Post 30) stimulation. The NWR threshold was obtained from biceps femoris muscle by applying electrical stimulation to the sural nerve. During taVNS, electrocardiogram was recorded, and changes in autonomic nervous activity measured by heart rate variability (HRV) were analyzed. We found that the NWR thresholds at Post 10 and Post 30 increased compared with baseline in the taVNS group (10 min after: p =.008, 30 min after: p =.008). In addition, increased parasympathetic activity by taVNS correlated with a greater increase in NWR threshold at Post 10 and Post 30 (Post 10: p =.003; Post 30: p =.001). The present results of this single‐blinded study demonstrate the pain‐suppressing effect of taVNS on NWR threshold and suggest that the degree of parasympathetic activation during taVNS may predict the pain‐suppressing effect of taVNS after its application. [ABSTRACT FROM AUTHOR] |
| Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 177378021 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Effects of transcutaneous auricular vagus nerve stimulation at left cymba concha on experimental pain as assessed with the nociceptive withdrawal reflex, and correlation with parasympathetic activity. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Yokota%2C+Hirotake%22">Yokota, Hirotake</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Edama%2C+Mutsuaki%22">Edama, Mutsuaki</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kawanabe%2C+Yurika%22">Kawanabe, Yurika</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hirabayashi%2C+Ryo%22">Hirabayashi, Ryo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sekikne%2C+Chie%22">Sekikne, Chie</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Akuzawa%2C+Hiroshi%22">Akuzawa, Hiroshi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ishigaki%2C+Tomonobu%22">Ishigaki, Tomonobu</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Otsuru%2C+Naofumi%22">Otsuru, Naofumi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Saito%2C+Kei%22">Saito, Kei</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kojima%2C+Sho%22">Kojima, Sho</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Miyaguchi%2C+Shota%22">Miyaguchi, Shota</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Onishi%2C+Hideaki%22">Onishi, Hideaki</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. May2024, Vol. 59 Issue 10, p2826-2835. 10p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Vagus+nerve+stimulation%22">Vagus nerve stimulation</searchLink><br /><searchLink fieldCode="DE" term="%22Parasympathetic+nervous+system%22">Parasympathetic nervous system</searchLink><br /><searchLink fieldCode="DE" term="%22Reflexes%22">Reflexes</searchLink><br /><searchLink fieldCode="DE" term="%22Vagus+nerve%22">Vagus nerve</searchLink><br /><searchLink fieldCode="DE" term="%22Neural+stimulation%22">Neural stimulation</searchLink><br /><searchLink fieldCode="DE" term="%22Electric+stimulation%22">Electric stimulation</searchLink><br /><searchLink fieldCode="DE" term="%22Heart+beat%22">Heart beat</searchLink><br /><searchLink fieldCode="DE" term="%22Biceps+femoris%22">Biceps femoris</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The aim of this study was to clarify the effects of transcutaneous auricular vagus nerve stimulation (taVNS) to the left cymba concha on the pain perception using nociceptive withdrawal reflex (NWR), which is known to be associated with chronic pain, and to investigate whether there is a relationship between taVNS‐induced suppression of the NWR and parasympathetic activation. We applied either 3.0 mA, 100 Hz taVNS for 120 s on the left cymba concha (taVNS condition) or the left earlobe (Sham condition) for 20 healthy adults. NWR threshold was measured before (Baseline), immediately after (Post 0), 10 min (Post 10) and 30 min after (Post 30) stimulation. The NWR threshold was obtained from biceps femoris muscle by applying electrical stimulation to the sural nerve. During taVNS, electrocardiogram was recorded, and changes in autonomic nervous activity measured by heart rate variability (HRV) were analyzed. We found that the NWR thresholds at Post 10 and Post 30 increased compared with baseline in the taVNS group (10 min after: p =.008, 30 min after: p =.008). In addition, increased parasympathetic activity by taVNS correlated with a greater increase in NWR threshold at Post 10 and Post 30 (Post 10: p =.003; Post 30: p =.001). The present results of this single‐blinded study demonstrate the pain‐suppressing effect of taVNS on NWR threshold and suggest that the degree of parasympathetic activation during taVNS may predict the pain‐suppressing effect of taVNS after its application. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=177378021 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/ejn.16305 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 10 StartPage: 2826 Subjects: – SubjectFull: Vagus nerve stimulation Type: general – SubjectFull: Parasympathetic nervous system Type: general – SubjectFull: Reflexes Type: general – SubjectFull: Vagus nerve Type: general – SubjectFull: Neural stimulation Type: general – SubjectFull: Electric stimulation Type: general – SubjectFull: Heart beat Type: general – SubjectFull: Biceps femoris Type: general Titles: – TitleFull: Effects of transcutaneous auricular vagus nerve stimulation at left cymba concha on experimental pain as assessed with the nociceptive withdrawal reflex, and correlation with parasympathetic activity. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Yokota, Hirotake – PersonEntity: Name: NameFull: Edama, Mutsuaki – PersonEntity: Name: NameFull: Kawanabe, Yurika – PersonEntity: Name: NameFull: Hirabayashi, Ryo – PersonEntity: Name: NameFull: Sekikne, Chie – PersonEntity: Name: NameFull: Akuzawa, Hiroshi – PersonEntity: Name: NameFull: Ishigaki, Tomonobu – PersonEntity: Name: NameFull: Otsuru, Naofumi – PersonEntity: Name: NameFull: Saito, Kei – PersonEntity: Name: NameFull: Kojima, Sho – PersonEntity: Name: NameFull: Miyaguchi, Shota – PersonEntity: Name: NameFull: Onishi, Hideaki IsPartOfRelationships: – BibEntity: Dates: – D: 15 M: 05 Text: May2024 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 0953816X Numbering: – Type: volume Value: 59 – Type: issue Value: 10 Titles: – TitleFull: European Journal of Neuroscience Type: main |
| ResultId | 1 |
