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Opportunities for risk‐taking during play alters cognitive performance and prefrontal inhibitory signalling in rats of both sexes.

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Title: Opportunities for risk‐taking during play alters cognitive performance and prefrontal inhibitory signalling in rats of both sexes.
Authors: Bijlsma, Ate (AUTHOR), Birza, Evelien E. (AUTHOR), Pimentel, Tara C. (AUTHOR), Maranus, Janneke P. M. (AUTHOR), van Gaans, Marieke J. J. M. (AUTHOR), Lozeman‐van t Klooster, José G. (AUTHOR), Baars, Annemarie J. M. (AUTHOR), Achterberg, E. J. Marijke (AUTHOR), Lesscher, Heidi M. B. (AUTHOR), Wierenga, Corette J. (AUTHOR), Vanderschuren, Louk J. M. J. (AUTHOR)
Source: European Journal of Neuroscience. May2024, Vol. 59 Issue 10, p2748-2765. 18p.
Subjects: Pyramidal neurons, Cognitive flexibility, Rats, Cognitive testing, Prefrontal cortex, Play environments, Animal social behavior
Abstract: Social play behaviour is a rewarding activity that can entail risks, thus allowing young individuals to test the limits of their capacities and to train their cognitive and emotional adaptability to challenges. Here, we tested in rats how opportunities for risk‐taking during play affect the development of cognitive and emotional capacities and medial prefrontal cortex (mPFC) function, a brain structure important for risk‐based decision making. Male and female rats were housed socially or social play‐deprived (SPD) between postnatal day (P)21 and P42. During this period, half of both groups were daily exposed to a high‐risk play environment. Around P85, all rats were tested for cognitive performance and emotional behaviour after which inhibitory currents were recorded in layer 5 pyramidal neurons in mPFC slices. We show that playing in a high‐risk environment altered cognitive flexibility in both sexes and improved behavioural inhibition in males. High‐risk play altered anxiety‐like behaviour in the elevated plus maze in males and in the open field in females, respectively. SPD affected cognitive flexibility in both sexes and decreased anxiety‐like behaviour in the elevated plus maze in females. We found that synaptic inhibitory currents in the mPFC were increased in male, but not female, rats after high‐risk play, while SPD lowered prefrontal cortex (PFC) synaptic inhibition in both sexes. Together, our data show that exposure to risks during play affects the development of cognition, emotional behaviour and inhibition in the mPFC. Furthermore, our study suggests that the opportunity to take risks during play cannot substitute for social play behaviour. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Label: Title
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  Data: Opportunities for risk‐taking during play alters cognitive performance and prefrontal inhibitory signalling in rats of both sexes.
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  Data: <searchLink fieldCode="AR" term="%22Bijlsma%2C+Ate%22">Bijlsma, Ate</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Birza%2C+Evelien+E%2E%22">Birza, Evelien E.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pimentel%2C+Tara+C%2E%22">Pimentel, Tara C.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Maranus%2C+Janneke+P%2E+M%2E%22">Maranus, Janneke P. M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22van+Gaans%2C+Marieke+J%2E+J%2E+M%2E%22">van Gaans, Marieke J. J. M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lozeman‐van+t+Klooster%2C+José+G%2E%22">Lozeman‐van t Klooster, José G.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Baars%2C+Annemarie+J%2E+M%2E%22">Baars, Annemarie J. M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Achterberg%2C+E%2E+J%2E+Marijke%22">Achterberg, E. J. Marijke</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lesscher%2C+Heidi+M%2E+B%2E%22">Lesscher, Heidi M. B.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wierenga%2C+Corette+J%2E%22">Wierenga, Corette J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vanderschuren%2C+Louk+J%2E+M%2E+J%2E%22">Vanderschuren, Louk J. M. J.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. May2024, Vol. 59 Issue 10, p2748-2765. 18p.
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  Data: <searchLink fieldCode="DE" term="%22Pyramidal+neurons%22">Pyramidal neurons</searchLink><br /><searchLink fieldCode="DE" term="%22Cognitive+flexibility%22">Cognitive flexibility</searchLink><br /><searchLink fieldCode="DE" term="%22Rats%22">Rats</searchLink><br /><searchLink fieldCode="DE" term="%22Cognitive+testing%22">Cognitive testing</searchLink><br /><searchLink fieldCode="DE" term="%22Prefrontal+cortex%22">Prefrontal cortex</searchLink><br /><searchLink fieldCode="DE" term="%22Play+environments%22">Play environments</searchLink><br /><searchLink fieldCode="DE" term="%22Animal+social+behavior%22">Animal social behavior</searchLink>
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  Data: Social play behaviour is a rewarding activity that can entail risks, thus allowing young individuals to test the limits of their capacities and to train their cognitive and emotional adaptability to challenges. Here, we tested in rats how opportunities for risk‐taking during play affect the development of cognitive and emotional capacities and medial prefrontal cortex (mPFC) function, a brain structure important for risk‐based decision making. Male and female rats were housed socially or social play‐deprived (SPD) between postnatal day (P)21 and P42. During this period, half of both groups were daily exposed to a high‐risk play environment. Around P85, all rats were tested for cognitive performance and emotional behaviour after which inhibitory currents were recorded in layer 5 pyramidal neurons in mPFC slices. We show that playing in a high‐risk environment altered cognitive flexibility in both sexes and improved behavioural inhibition in males. High‐risk play altered anxiety‐like behaviour in the elevated plus maze in males and in the open field in females, respectively. SPD affected cognitive flexibility in both sexes and decreased anxiety‐like behaviour in the elevated plus maze in females. We found that synaptic inhibitory currents in the mPFC were increased in male, but not female, rats after high‐risk play, while SPD lowered prefrontal cortex (PFC) synaptic inhibition in both sexes. Together, our data show that exposure to risks during play affects the development of cognition, emotional behaviour and inhibition in the mPFC. Furthermore, our study suggests that the opportunity to take risks during play cannot substitute for social play behaviour. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=177378029
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        Value: 10.1111/ejn.16313
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      – Code: eng
        Text: English
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        PageCount: 18
        StartPage: 2748
    Subjects:
      – SubjectFull: Pyramidal neurons
        Type: general
      – SubjectFull: Cognitive flexibility
        Type: general
      – SubjectFull: Rats
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      – SubjectFull: Cognitive testing
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      – SubjectFull: Prefrontal cortex
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      – SubjectFull: Play environments
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      – SubjectFull: Animal social behavior
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              Text: May2024
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