Cross-ancestry atlas of gene, isoform, and splicing regulation in the developing human brain.
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| Title: | Cross-ancestry atlas of gene, isoform, and splicing regulation in the developing human brain. |
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| Authors: | Wen, Cindy, Margolis, Michael, Dai, Rujia, Pan Zhang, Przytycki, Pawel F., Vo, Daniel D., Bhattacharya, Arjun, Matoba, Nana, Miao Tang, Chuan Jiao, Minsoo Kim, Tsai, Ellen, Hoh, Celine, Aygün, Nil, Walker, Rebecca L., Chatzinakos, Christos, Clarke, Declan, Pratt, Henry, Consortium, PsychENCODE, Peters, Mette A. |
| Source: | Science (pre-March 2025). 5/24/2024, Vol. 384 Issue 6698, p869-869. 1p. 1 Diagram. |
| Subjects: | RNA splicing, Locus (Genetics), Genes, Genetic regulation, Genetic engineering, Gene expression |
| Abstract: | The article offers information on the generation of a unified, population-scale gene-regulatory atlas of human brain development, systematically characterizing gene, isoform, and splicing quantitative trait loci (xQTLs) across 672 samples from diverse ancestries. Topics include the identification of genes harboring cis-xQTLs; the timing and molecular features of neuropsychiatric GWAS heritability; and the prioritization of candidate risk genes and mechanisms for top loci. |
| Database: | Psychology and Behavioral Sciences Collection |
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