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Association of dopamine β-hydroxylase polymorphism rs1611115 and serum levels with psychiatric disorders in Pakistani population.

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Title: Association of dopamine β-hydroxylase polymorphism rs1611115 and serum levels with psychiatric disorders in Pakistani population.
Authors: Hashmi, Aisha Nasir (AUTHOR), Ahmed Dharejo, Raees (AUTHOR), Zubair, Usama Bin (AUTHOR), Khan, Netasha (AUTHOR), Kashif, Iqra (AUTHOR), Ajmal, Muhammad (AUTHOR), Taj, Rizwan (AUTHOR), Qamar, Raheel (AUTHOR), Azam, Maleeha (AUTHOR)
Source: International Journal of Neuroscience. Jun2024, Vol. 134 Issue 6, p551-559. 9p.
Subjects: Pakistanis, Mental illness, Mann Whitney U Test, Dopamine, Risperidone, Bipolar disorder, Catechol-O-methyltransferase
Abstract: Dopamine β-hydroxylase (DBH) is a copper-containing enzyme that has an important role in maintaining the cellular homeostasis between the two neurotransmitters, dopamine (DA) and nor-adrenaline (NA). DBH functional polymorphisms are associated with multiple neuro-psychiatric conditions and are found to alter the DBH protein levels in serum affecting DBH enzymatic activity. The current study was conducted to determine the genetic and serum levels association of DBH rs1611115 functional polymorphism with major depressive disorder (MDD), bipolar disorder (BD) and schizophrenia (SHZ) in the Pakistani population. In total n = 1097 subjects including MDD (n = 427), BD (n = 204), SHZ (n = 134) and healthy controls (n = 332), were screened for the functional polymorphism by polymerase chain reaction-restriction fragment length polymorphism. Univariate logistic regression analysis was applied and the results were adjusted for age and sex. The DBH levels in serum were determined through enzyme-linked immunosorbent assay (ELISA) and the Mann Whitney U test was applied. The minor allele (-1021 C > T) was found to be significantly associated with a higher risk of developing BD and SHZ in both univariable and multivariable analyses. The overall total serum concentration of DBH was comparatively raised in MDD, however, in cross-comparison DBH serum levels were found markedly higher in CC homozygotes compared to TT homozygotes within the BD group. The present study suggested a significant association of DBH rs1611115 with BD and SHZ and also the effect of rs1611115 on DBH serum levels in MDD and BD for the first time in the Pakistani population. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Label: Title
  Group: Ti
  Data: Association of dopamine β-hydroxylase polymorphism rs1611115 and serum levels with psychiatric disorders in Pakistani population.
– Name: Author
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  Data: <searchLink fieldCode="AR" term="%22Hashmi%2C+Aisha+Nasir%22">Hashmi, Aisha Nasir</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ahmed+Dharejo%2C+Raees%22">Ahmed Dharejo, Raees</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zubair%2C+Usama+Bin%22">Zubair, Usama Bin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Khan%2C+Netasha%22">Khan, Netasha</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kashif%2C+Iqra%22">Kashif, Iqra</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ajmal%2C+Muhammad%22">Ajmal, Muhammad</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Taj%2C+Rizwan%22">Taj, Rizwan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Qamar%2C+Raheel%22">Qamar, Raheel</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Azam%2C+Maleeha%22">Azam, Maleeha</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Neuroscience%22">International Journal of Neuroscience</searchLink>. Jun2024, Vol. 134 Issue 6, p551-559. 9p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Pakistanis%22">Pakistanis</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+illness%22">Mental illness</searchLink><br /><searchLink fieldCode="DE" term="%22Mann+Whitney+U+Test%22">Mann Whitney U Test</searchLink><br /><searchLink fieldCode="DE" term="%22Dopamine%22">Dopamine</searchLink><br /><searchLink fieldCode="DE" term="%22Risperidone%22">Risperidone</searchLink><br /><searchLink fieldCode="DE" term="%22Bipolar+disorder%22">Bipolar disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Catechol-O-methyltransferase%22">Catechol-O-methyltransferase</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Dopamine β-hydroxylase (DBH) is a copper-containing enzyme that has an important role in maintaining the cellular homeostasis between the two neurotransmitters, dopamine (DA) and nor-adrenaline (NA). DBH functional polymorphisms are associated with multiple neuro-psychiatric conditions and are found to alter the DBH protein levels in serum affecting DBH enzymatic activity. The current study was conducted to determine the genetic and serum levels association of DBH rs1611115 functional polymorphism with major depressive disorder (MDD), bipolar disorder (BD) and schizophrenia (SHZ) in the Pakistani population. In total n = 1097 subjects including MDD (n = 427), BD (n = 204), SHZ (n = 134) and healthy controls (n = 332), were screened for the functional polymorphism by polymerase chain reaction-restriction fragment length polymorphism. Univariate logistic regression analysis was applied and the results were adjusted for age and sex. The DBH levels in serum were determined through enzyme-linked immunosorbent assay (ELISA) and the Mann Whitney U test was applied. The minor allele (-1021 C > T) was found to be significantly associated with a higher risk of developing BD and SHZ in both univariable and multivariable analyses. The overall total serum concentration of DBH was comparatively raised in MDD, however, in cross-comparison DBH serum levels were found markedly higher in CC homozygotes compared to TT homozygotes within the BD group. The present study suggested a significant association of DBH rs1611115 with BD and SHZ and also the effect of rs1611115 on DBH serum levels in MDD and BD for the first time in the Pakistani population. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1080/00207454.2022.2126774
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      – Code: eng
        Text: English
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      Pagination:
        PageCount: 9
        StartPage: 551
    Subjects:
      – SubjectFull: Pakistanis
        Type: general
      – SubjectFull: Mental illness
        Type: general
      – SubjectFull: Mann Whitney U Test
        Type: general
      – SubjectFull: Dopamine
        Type: general
      – SubjectFull: Risperidone
        Type: general
      – SubjectFull: Bipolar disorder
        Type: general
      – SubjectFull: Catechol-O-methyltransferase
        Type: general
    Titles:
      – TitleFull: Association of dopamine β-hydroxylase polymorphism rs1611115 and serum levels with psychiatric disorders in Pakistani population.
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            NameFull: Hashmi, Aisha Nasir
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            – D: 01
              M: 06
              Text: Jun2024
              Type: published
              Y: 2024
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