Effect of an herbal formulation containing Peganum harmala L. and Fraxinus excelsior L. on oxidative stress, memory impairment and withdrawal syndrome induced by morphine.
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| Title: | Effect of an herbal formulation containing Peganum harmala L. and Fraxinus excelsior L. on oxidative stress, memory impairment and withdrawal syndrome induced by morphine. |
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| Authors: | Ahmadianmoghadam, Mohammad Ali (AUTHOR), Nematollahi, Mohammad Hadi (AUTHOR), Mehrabani, Mitra (AUTHOR), Fatemi, Iman (AUTHOR), Rostamzadeh, Farzaneh (AUTHOR), Dell'Agli, Mario (AUTHOR), Mehrabani, Mehrnaz (AUTHOR), Abolhassani, Moslem (AUTHOR), Mehrbani, Mehrzad (AUTHOR) |
| Source: | International Journal of Neuroscience. Jun2024, Vol. 134 Issue 6, p570-583. 14p. |
| Subjects: | Peganum harmala, European ash, Drug withdrawal symptoms, Sodium carboxymethyl cellulose, Memory disorders, Oxidative stress, Ellagic acid, Ginger |
| Abstract: | Background: Traditional Persian medicine has introduced effective remedies in opioid dependence care. One of the most widely used remedies is an herbal formulation containing Peganum harmala L. and Fraxinus excelsior L. (HF). This study investigated the effects of HF to attenuate the withdrawal signs and rewarding effects in morphine-dependent rats. Methods: Forty-nine male Wistar rats were randomly divided into seven groups. The control and vehicle groups received normal saline and sodium carboxymethyl cellulose, respectively. The morphine group received morphine for one week. The single and daily dose of HF groups received morphine similar to the morphine group, and HF (1.4 and 2.8 g/kg) once a day in the daily dose group and only on the last day of the experiment in the single dose of HF group. Finally, the withdrawal signs as well biochemical tests were evaluated. The behavioral parameters were assessed by conditioned place preference (CPP), elevated plus-maze and Y-maze tests. The antioxidant activity of HF was evaluated by measurement of serum contents of malondialdehyde, stable nitric oxide metabolites and total antioxidant capacity (TAC). Moreover, the protein expression of c-fos was assessed by western blotting. Results: Daily treatment with HF significantly reduced the score of CPP behavioral test, all of the withdrawal signs, TAC and the c-fos protein level. Conclusions: The results indicated that HF might be a promising complementary treatment in reducing morphine-induced physical and psychological dependence probably through modulation of c-fos protein expression. [ABSTRACT FROM AUTHOR] |
| Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 177520060 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Effect of an herbal formulation containing Peganum harmala L. and Fraxinus excelsior L. on oxidative stress, memory impairment and withdrawal syndrome induced by morphine. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Ahmadianmoghadam%2C+Mohammad+Ali%22">Ahmadianmoghadam, Mohammad Ali</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nematollahi%2C+Mohammad+Hadi%22">Nematollahi, Mohammad Hadi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mehrabani%2C+Mitra%22">Mehrabani, Mitra</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fatemi%2C+Iman%22">Fatemi, Iman</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rostamzadeh%2C+Farzaneh%22">Rostamzadeh, Farzaneh</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dell'Agli%2C+Mario%22">Dell'Agli, Mario</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mehrabani%2C+Mehrnaz%22">Mehrabani, Mehrnaz</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Abolhassani%2C+Moslem%22">Abolhassani, Moslem</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mehrbani%2C+Mehrzad%22">Mehrbani, Mehrzad</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Neuroscience%22">International Journal of Neuroscience</searchLink>. Jun2024, Vol. 134 Issue 6, p570-583. 14p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Peganum+harmala%22">Peganum harmala</searchLink><br /><searchLink fieldCode="DE" term="%22European+ash%22">European ash</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+withdrawal+symptoms%22">Drug withdrawal symptoms</searchLink><br /><searchLink fieldCode="DE" term="%22Sodium+carboxymethyl+cellulose%22">Sodium carboxymethyl cellulose</searchLink><br /><searchLink fieldCode="DE" term="%22Memory+disorders%22">Memory disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Oxidative+stress%22">Oxidative stress</searchLink><br /><searchLink fieldCode="DE" term="%22Ellagic+acid%22">Ellagic acid</searchLink><br /><searchLink fieldCode="DE" term="%22Ginger%22">Ginger</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background: Traditional Persian medicine has introduced effective remedies in opioid dependence care. One of the most widely used remedies is an herbal formulation containing Peganum harmala L. and Fraxinus excelsior L. (HF). This study investigated the effects of HF to attenuate the withdrawal signs and rewarding effects in morphine-dependent rats. Methods: Forty-nine male Wistar rats were randomly divided into seven groups. The control and vehicle groups received normal saline and sodium carboxymethyl cellulose, respectively. The morphine group received morphine for one week. The single and daily dose of HF groups received morphine similar to the morphine group, and HF (1.4 and 2.8 g/kg) once a day in the daily dose group and only on the last day of the experiment in the single dose of HF group. Finally, the withdrawal signs as well biochemical tests were evaluated. The behavioral parameters were assessed by conditioned place preference (CPP), elevated plus-maze and Y-maze tests. The antioxidant activity of HF was evaluated by measurement of serum contents of malondialdehyde, stable nitric oxide metabolites and total antioxidant capacity (TAC). Moreover, the protein expression of c-fos was assessed by western blotting. Results: Daily treatment with HF significantly reduced the score of CPP behavioral test, all of the withdrawal signs, TAC and the c-fos protein level. Conclusions: The results indicated that HF might be a promising complementary treatment in reducing morphine-induced physical and psychological dependence probably through modulation of c-fos protein expression. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=177520060 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1080/00207454.2022.2130293 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 14 StartPage: 570 Subjects: – SubjectFull: Peganum harmala Type: general – SubjectFull: European ash Type: general – SubjectFull: Drug withdrawal symptoms Type: general – SubjectFull: Sodium carboxymethyl cellulose Type: general – SubjectFull: Memory disorders Type: general – SubjectFull: Oxidative stress Type: general – SubjectFull: Ellagic acid Type: general – SubjectFull: Ginger Type: general Titles: – TitleFull: Effect of an herbal formulation containing Peganum harmala L. and Fraxinus excelsior L. on oxidative stress, memory impairment and withdrawal syndrome induced by morphine. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Ahmadianmoghadam, Mohammad Ali – PersonEntity: Name: NameFull: Nematollahi, Mohammad Hadi – PersonEntity: Name: NameFull: Mehrabani, Mitra – PersonEntity: Name: NameFull: Fatemi, Iman – PersonEntity: Name: NameFull: Rostamzadeh, Farzaneh – PersonEntity: Name: NameFull: Dell'Agli, Mario – PersonEntity: Name: NameFull: Mehrabani, Mehrnaz – PersonEntity: Name: NameFull: Abolhassani, Moslem – PersonEntity: Name: NameFull: Mehrbani, Mehrzad IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 06 Text: Jun2024 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 00207454 Numbering: – Type: volume Value: 134 – Type: issue Value: 6 Titles: – TitleFull: International Journal of Neuroscience Type: main |
| ResultId | 1 |
