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Xanthohumol Promotes Skp2 Ubiquitination Leading to the Inhibition of Glycolysis and Tumorigenesis in Ovarian Cancer.

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Title: Xanthohumol Promotes Skp2 Ubiquitination Leading to the Inhibition of Glycolysis and Tumorigenesis in Ovarian Cancer.
Authors: He, Yi-Fu (AUTHOR), Liu, Yi-Ping (AUTHOR), Liao, Jin-Zhuang (AUTHOR), Gan, Yu (AUTHOR), Li, Xiaoying (AUTHOR), Wang, Rui-Rui (AUTHOR), Wang, Fang (AUTHOR), Zhou, Jun (AUTHOR), Zhou, Li (AUTHOR)
Source: American Journal of Chinese Medicine. 2024, Vol. 52 Issue 3, p865-884. 20p.
Subjects: Clinical drug trials, Biological models, In vitro studies, Leukocyte count, Carrier proteins, Phenomenological biology, Research funding, Erythrocytes, Platelet count, T-test (Statistics), Flavonoids, Antineoplastic agents, Ovarian tumors, Apoptosis, Cell proliferation, Hemoglobins, Aspartate aminotransferase, Biochemistry, Biological products, Xenografts, Enzymes, Glycoproteins, In vivo studies, Cellular signal transduction, Culture media (Biology), Blood urea nitrogen, Descriptive statistics, Quantitative research, Heart, Cell lines, Mice, Cell culture, Immunohistochemistry, Gene expression, Animal experimentation, Molecular structure, Hospital laboratories, Alanine aminotransferase, Analysis of variance, Carcinogenesis, Cell survival, Transferases, Stains & staining (Microscopy), Data analysis software, Liver, Warburg Effect (Oncology), Immunoblotting, Kidneys, Pharmacodynamics
Geographic Terms: China
Abstract: Ovarian cancer is a common, highly lethal tumor. Herein, we reported that S-phase kinase-associated protein 2 (Skp2) is essential for the growth and aerobic glycolysis of ovarian cancer cells. Skp2 was upregulated in ovarian cancer tissues and associated with poor clinical outcomes. Using a customized natural product library screening, we found that xanthohumol inhibited aerobic glycolysis and cell viability of ovarian cancer cells. Xanthohumol facilitated the interaction between E3 ligase Cdh1 and Skp2 and promoted the Ub-K48-linked polyubiquitination of Skp2 and degradation. Cdh1 depletion reversed xanthohumol-induced Skp2 downregulation, enhancing HK2 expression and glycolysis in ovarian cancer cells. Finally, a xenograft tumor model was employed to examine the antitumor efficacy of xanthohumol in vivo. Collectively, we discovered that xanthohumol promotes the binding between Skp2 and Cdh1 to suppress the Skp2/AKT/HK2 signal pathway and exhibits potential antitumor activity for ovarian cancer cells. [ABSTRACT FROM AUTHOR]
Copyright of American Journal of Chinese Medicine is the property of World Scientific Publishing Company and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Xanthohumol Promotes Skp2 Ubiquitination Leading to the Inhibition of Glycolysis and Tumorigenesis in Ovarian Cancer.
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  Data: Ovarian cancer is a common, highly lethal tumor. Herein, we reported that S-phase kinase-associated protein 2 (Skp2) is essential for the growth and aerobic glycolysis of ovarian cancer cells. Skp2 was upregulated in ovarian cancer tissues and associated with poor clinical outcomes. Using a customized natural product library screening, we found that xanthohumol inhibited aerobic glycolysis and cell viability of ovarian cancer cells. Xanthohumol facilitated the interaction between E3 ligase Cdh1 and Skp2 and promoted the Ub-K48-linked polyubiquitination of Skp2 and degradation. Cdh1 depletion reversed xanthohumol-induced Skp2 downregulation, enhancing HK2 expression and glycolysis in ovarian cancer cells. Finally, a xenograft tumor model was employed to examine the antitumor efficacy of xanthohumol in vivo. Collectively, we discovered that xanthohumol promotes the binding between Skp2 and Cdh1 to suppress the Skp2/AKT/HK2 signal pathway and exhibits potential antitumor activity for ovarian cancer cells. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of American Journal of Chinese Medicine is the property of World Scientific Publishing Company and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1142/S0192415X24500356
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      – Code: eng
        Text: English
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        PageCount: 20
        StartPage: 865
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      – SubjectFull: Clinical drug trials
        Type: general
      – SubjectFull: Biological models
        Type: general
      – SubjectFull: In vitro studies
        Type: general
      – SubjectFull: Leukocyte count
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      – SubjectFull: Carrier proteins
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      – SubjectFull: Research funding
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      – SubjectFull: Antineoplastic agents
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      – SubjectFull: Ovarian tumors
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      – SubjectFull: Apoptosis
        Type: general
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      – SubjectFull: Quantitative research
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      – SubjectFull: Cell lines
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      – SubjectFull: Mice
        Type: general
      – SubjectFull: Cell culture
        Type: general
      – SubjectFull: Immunohistochemistry
        Type: general
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        Type: general
      – SubjectFull: Alanine aminotransferase
        Type: general
      – SubjectFull: Analysis of variance
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      – SubjectFull: Carcinogenesis
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      – SubjectFull: Cell survival
        Type: general
      – SubjectFull: Transferases
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      – SubjectFull: Stains & staining (Microscopy)
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      – SubjectFull: Data analysis software
        Type: general
      – SubjectFull: Liver
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      – SubjectFull: Warburg Effect (Oncology)
        Type: general
      – SubjectFull: Immunoblotting
        Type: general
      – SubjectFull: Kidneys
        Type: general
      – SubjectFull: Pharmacodynamics
        Type: general
      – SubjectFull: China
        Type: general
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      – TitleFull: Xanthohumol Promotes Skp2 Ubiquitination Leading to the Inhibition of Glycolysis and Tumorigenesis in Ovarian Cancer.
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              M: 03
              Text: 2024
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