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Psilocybin does not induce the vulnerability marker HSP70 in neurons susceptible to Olney's lesions.

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Title: Psilocybin does not induce the vulnerability marker HSP70 in neurons susceptible to Olney's lesions.
Authors: Iorgu, Ana-Maria (AUTHOR), Vasilescu, Andrei-Nicolae (AUTHOR), Pfeiffer, Natascha (AUTHOR), Spanagel, Rainer (AUTHOR), Mallien, Anne Stephanie (AUTHOR), Inta, Dragos (AUTHOR), Gass, Peter (AUTHOR)
Source: European Archives of Psychiatry & Clinical Neuroscience. Jun2024, Vol. 274 Issue 4, p1013-1019. 7p.
Subjects: Psilocybin, Methyl aspartate receptors, Cingulate cortex, Heat shock proteins, Neurons, Serotonin syndrome
Abstract: S-ketamine, a N-methyl-D-aspartate receptor (NMDAR) antagonist, and psilocybin, a 5-hydroxy-tryptamine (serotonin) 2A receptor (5-HT2AR) agonist, are reported as effective rapid-acting antidepressants. Both compounds increase glutamate signalling and evoke cortical hyperexcitation. S-ketamine induces neurotoxicity especially in the retrosplenial cortex (Olney's lesions). Whether psilocybin produces similar neurotoxic effects has so far not been investigated. We performed an immunohistochemical whole-brain mapping for heat shock protein 70 (HSP70) in rats treated with psilocybin, S-ketamine, and MK-801. In contrast to S-ketamine- and MK-801-treated animals, we did not detect any HSP70-positive neurons in retrosplenial cortex of rats treated with psilocybin. Our results suggest that psilocybin might be safer for clinical use compared to S-ketamine regarding neuronal damage. [ABSTRACT FROM AUTHOR]
Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Psilocybin does not induce the vulnerability marker HSP70 in neurons susceptible to Olney's lesions.
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  Data: <searchLink fieldCode="AR" term="%22Iorgu%2C+Ana-Maria%22">Iorgu, Ana-Maria</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vasilescu%2C+Andrei-Nicolae%22">Vasilescu, Andrei-Nicolae</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pfeiffer%2C+Natascha%22">Pfeiffer, Natascha</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Spanagel%2C+Rainer%22">Spanagel, Rainer</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mallien%2C+Anne+Stephanie%22">Mallien, Anne Stephanie</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Inta%2C+Dragos%22">Inta, Dragos</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gass%2C+Peter%22">Gass, Peter</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Archives+of+Psychiatry+%26+Clinical+Neuroscience%22">European Archives of Psychiatry & Clinical Neuroscience</searchLink>. Jun2024, Vol. 274 Issue 4, p1013-1019. 7p.
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  Data: <searchLink fieldCode="DE" term="%22Psilocybin%22">Psilocybin</searchLink><br /><searchLink fieldCode="DE" term="%22Methyl+aspartate+receptors%22">Methyl aspartate receptors</searchLink><br /><searchLink fieldCode="DE" term="%22Cingulate+cortex%22">Cingulate cortex</searchLink><br /><searchLink fieldCode="DE" term="%22Heat+shock+proteins%22">Heat shock proteins</searchLink><br /><searchLink fieldCode="DE" term="%22Neurons%22">Neurons</searchLink><br /><searchLink fieldCode="DE" term="%22Serotonin+syndrome%22">Serotonin syndrome</searchLink>
– Name: Abstract
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  Data: S-ketamine, a N-methyl-D-aspartate receptor (NMDAR) antagonist, and psilocybin, a 5-hydroxy-tryptamine (serotonin) 2A receptor (5-HT2AR) agonist, are reported as effective rapid-acting antidepressants. Both compounds increase glutamate signalling and evoke cortical hyperexcitation. S-ketamine induces neurotoxicity especially in the retrosplenial cortex (Olney's lesions). Whether psilocybin produces similar neurotoxic effects has so far not been investigated. We performed an immunohistochemical whole-brain mapping for heat shock protein 70 (HSP70) in rats treated with psilocybin, S-ketamine, and MK-801. In contrast to S-ketamine- and MK-801-treated animals, we did not detect any HSP70-positive neurons in retrosplenial cortex of rats treated with psilocybin. Our results suggest that psilocybin might be safer for clinical use compared to S-ketamine regarding neuronal damage. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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              Text: Jun2024
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