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Appetite hormone dysregulation and executive dysfunction among adolescents with bipolar disorder and disruptive mood dysregulation disorder.

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Title: Appetite hormone dysregulation and executive dysfunction among adolescents with bipolar disorder and disruptive mood dysregulation disorder.
Authors: Hsu, Ju-Wei, Chen, Li-Chi, Huang, Kai-Lin, Bai, Ya-Mei, Tsai, Shih-Jen, Su, Tung-Ping, Chen, Mu-Hong
Source: European Child & Adolescent Psychiatry. Apr2024, Vol. 33 Issue 4, p1113-1120. 8p.
Subjects: Bipolar disorder, Behavior disorders, Pearson correlation (Statistics), Hormones, Research funding, Executive function, Cognition disorders in adolescence, Appetite, Affective disorders, Descriptive statistics, Data analysis software, Adolescence
Abstract: Appetite hormone dysregulation may play a role in the pathomechanisms of bipolar disorder and chronic irritability. However, its association with executive dysfunction in adolescents with bipolar disorder and those with disruptive mood dysregulation disorder (DMDD) remains unclear. We included 20 adolescents with bipolar disorder, 20 adolescents with DMDD, and 47 healthy controls. Fasting serum levels of appetite hormones, including leptin, ghrelin, insulin, and adiponectin were examined. All participants completed the Wisconsin Card Sorting Test. Generalized linear models with adjustments for age, sex, body mass index, and clinical symptoms revealed that patients with DMDD had elevated fasting log-transformed insulin levels (p =.023) compared to the control group. Adolescents with DMDD performed worse in terms of the number of tries required to complete tasks associated with the first category (p =.035), and adolescents with bipolar disorder performed worse in terms of the number of categories completed (p =.035). A positive correlation was observed between log-transformed insulin levels and the number of tries required for the first category (β = 1.847, p =.032). Adolescents with DMDD, but not those with bipolar disorder, were more likely to exhibit appetite hormone dysregulation compared to healthy controls. Increased insulin levels were also related to executive dysfunction in these patients. Prospective studies should elucidate the temporal association between appetite hormone dysregulation, executive dysfunction, and emotional dysregulation. [ABSTRACT FROM AUTHOR]
Copyright of European Child & Adolescent Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Appetite hormone dysregulation and executive dysfunction among adolescents with bipolar disorder and disruptive mood dysregulation disorder.
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  Data: <searchLink fieldCode="AR" term="%22Hsu%2C+Ju-Wei%22">Hsu, Ju-Wei</searchLink><br /><searchLink fieldCode="AR" term="%22Chen%2C+Li-Chi%22">Chen, Li-Chi</searchLink><br /><searchLink fieldCode="AR" term="%22Huang%2C+Kai-Lin%22">Huang, Kai-Lin</searchLink><br /><searchLink fieldCode="AR" term="%22Bai%2C+Ya-Mei%22">Bai, Ya-Mei</searchLink><br /><searchLink fieldCode="AR" term="%22Tsai%2C+Shih-Jen%22">Tsai, Shih-Jen</searchLink><br /><searchLink fieldCode="AR" term="%22Su%2C+Tung-Ping%22">Su, Tung-Ping</searchLink><br /><searchLink fieldCode="AR" term="%22Chen%2C+Mu-Hong%22">Chen, Mu-Hong</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22European+Child+%26+Adolescent+Psychiatry%22">European Child & Adolescent Psychiatry</searchLink>. Apr2024, Vol. 33 Issue 4, p1113-1120. 8p.
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  Data: Appetite hormone dysregulation may play a role in the pathomechanisms of bipolar disorder and chronic irritability. However, its association with executive dysfunction in adolescents with bipolar disorder and those with disruptive mood dysregulation disorder (DMDD) remains unclear. We included 20 adolescents with bipolar disorder, 20 adolescents with DMDD, and 47 healthy controls. Fasting serum levels of appetite hormones, including leptin, ghrelin, insulin, and adiponectin were examined. All participants completed the Wisconsin Card Sorting Test. Generalized linear models with adjustments for age, sex, body mass index, and clinical symptoms revealed that patients with DMDD had elevated fasting log-transformed insulin levels (p =.023) compared to the control group. Adolescents with DMDD performed worse in terms of the number of tries required to complete tasks associated with the first category (p =.035), and adolescents with bipolar disorder performed worse in terms of the number of categories completed (p =.035). A positive correlation was observed between log-transformed insulin levels and the number of tries required for the first category (β = 1.847, p =.032). Adolescents with DMDD, but not those with bipolar disorder, were more likely to exhibit appetite hormone dysregulation compared to healthy controls. Increased insulin levels were also related to executive dysfunction in these patients. Prospective studies should elucidate the temporal association between appetite hormone dysregulation, executive dysfunction, and emotional dysregulation. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of European Child & Adolescent Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s00787-023-02237-1
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        Text: English
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        PageCount: 8
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      – SubjectFull: Bipolar disorder
        Type: general
      – SubjectFull: Behavior disorders
        Type: general
      – SubjectFull: Pearson correlation (Statistics)
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      – SubjectFull: Hormones
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      – SubjectFull: Executive function
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      – SubjectFull: Cognition disorders in adolescence
        Type: general
      – SubjectFull: Appetite
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      – SubjectFull: Adolescence
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              Text: Apr2024
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