Prognostic relevance of the C‐X‐C motif chemokine ligand 13 and interleukin‐8 in predicting the transition from clinically isolated syndrome to multiple sclerosis.
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| Title: | Prognostic relevance of the C‐X‐C motif chemokine ligand 13 and interleukin‐8 in predicting the transition from clinically isolated syndrome to multiple sclerosis. |
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| Authors: | Klíčová, Kateřina (AUTHOR), Mareš, Jan (AUTHOR), Sobek, Ondřej (AUTHOR), Rous, Zuzana (AUTHOR), Rous, Matouš (AUTHOR), Raška, Milan (AUTHOR), Hartung, Hans‐Peter (AUTHOR) |
| Source: | European Journal of Neuroscience. Jun2024, Vol. 59 Issue 11, p2955-2966. 12p. |
| Subjects: | Cerebrospinal fluid examination, Receiver operating characteristic curves, Multiple sclerosis, Interleukin-8, Macrophage colony-stimulating factor, Central nervous system |
| Abstract: | The initial phase of multiple sclerosis (MS), often known as clinically isolated syndrome (CIS), is a critical period for identifying individuals at high risk of progressing to full‐blown MS and initiating timely treatment. In this study, we aimed to evaluate the prognostic value of C‐X‐C motif chemokine ligand 13 (CXCL13) and interleukin‐8 (IL‐8) as potential markers for CIS patients' conversion to MS. Our study encompassed patients with CIS, those with relapsing–remitting MS (RRMS), and control subjects, with sample analysis conducted on both cerebrospinal fluid (CSF) and serum. Patients were categorized into four groups: CIS–CIS (no MS development within 2 years), CIS–RRMS (conversion to RRMS within 2 years), RRMS (already diagnosed), and a control group (CG) with noninflammatory central nervous system disorders. Results showed significantly elevated levels of CXCL13 in CSF across all patient groups compared with the CG (p < 0.0001, Kruskal–Wallis test). Although CXCL13 concentrations were slightly higher in the CIS–RRMS group, statistical significance was not reached. Similarly, significantly higher levels of IL‐8 were detected in CSF samples from all patient groups compared with the CG (p < 0.0001, Kruskal–Wallis test). Receiver operating characteristic analysis in the CIS–RRMS group identified both CXCL13 (area under receiver operating characteristic curve =.959) and IL‐8 (area under receiver operating characteristic curve =.939) in CSF as significant predictors of CIS to RRMS conversion. In conclusion, our study suggests a trend towards elevated CSF IL‐8 and CSF CXCL13 levels in CIS patients progressing to RRMS. These findings emphasize the importance of identifying prognostic markers to guide appropriate treatment strategies for individuals in the early stages of MS. [ABSTRACT FROM AUTHOR] |
| Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 177649818 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Prognostic relevance of the C‐X‐C motif chemokine ligand 13 and interleukin‐8 in predicting the transition from clinically isolated syndrome to multiple sclerosis. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Klíčová%2C+Kateřina%22">Klíčová, Kateřina</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mareš%2C+Jan%22">Mareš, Jan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sobek%2C+Ondřej%22">Sobek, Ondřej</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rous%2C+Zuzana%22">Rous, Zuzana</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rous%2C+Matouš%22">Rous, Matouš</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Raška%2C+Milan%22">Raška, Milan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hartung%2C+Hans‐Peter%22">Hartung, Hans‐Peter</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Jun2024, Vol. 59 Issue 11, p2955-2966. 12p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Cerebrospinal+fluid+examination%22">Cerebrospinal fluid examination</searchLink><br /><searchLink fieldCode="DE" term="%22Receiver+operating+characteristic+curves%22">Receiver operating characteristic curves</searchLink><br /><searchLink fieldCode="DE" term="%22Multiple+sclerosis%22">Multiple sclerosis</searchLink><br /><searchLink fieldCode="DE" term="%22Interleukin-8%22">Interleukin-8</searchLink><br /><searchLink fieldCode="DE" term="%22Macrophage+colony-stimulating+factor%22">Macrophage colony-stimulating factor</searchLink><br /><searchLink fieldCode="DE" term="%22Central+nervous+system%22">Central nervous system</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The initial phase of multiple sclerosis (MS), often known as clinically isolated syndrome (CIS), is a critical period for identifying individuals at high risk of progressing to full‐blown MS and initiating timely treatment. In this study, we aimed to evaluate the prognostic value of C‐X‐C motif chemokine ligand 13 (CXCL13) and interleukin‐8 (IL‐8) as potential markers for CIS patients' conversion to MS. Our study encompassed patients with CIS, those with relapsing–remitting MS (RRMS), and control subjects, with sample analysis conducted on both cerebrospinal fluid (CSF) and serum. Patients were categorized into four groups: CIS–CIS (no MS development within 2 years), CIS–RRMS (conversion to RRMS within 2 years), RRMS (already diagnosed), and a control group (CG) with noninflammatory central nervous system disorders. Results showed significantly elevated levels of CXCL13 in CSF across all patient groups compared with the CG (p < 0.0001, Kruskal–Wallis test). Although CXCL13 concentrations were slightly higher in the CIS–RRMS group, statistical significance was not reached. Similarly, significantly higher levels of IL‐8 were detected in CSF samples from all patient groups compared with the CG (p < 0.0001, Kruskal–Wallis test). Receiver operating characteristic analysis in the CIS–RRMS group identified both CXCL13 (area under receiver operating characteristic curve =.959) and IL‐8 (area under receiver operating characteristic curve =.939) in CSF as significant predictors of CIS to RRMS conversion. In conclusion, our study suggests a trend towards elevated CSF IL‐8 and CSF CXCL13 levels in CIS patients progressing to RRMS. These findings emphasize the importance of identifying prognostic markers to guide appropriate treatment strategies for individuals in the early stages of MS. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/ejn.16300 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 12 StartPage: 2955 Subjects: – SubjectFull: Cerebrospinal fluid examination Type: general – SubjectFull: Receiver operating characteristic curves Type: general – SubjectFull: Multiple sclerosis Type: general – SubjectFull: Interleukin-8 Type: general – SubjectFull: Macrophage colony-stimulating factor Type: general – SubjectFull: Central nervous system Type: general Titles: – TitleFull: Prognostic relevance of the C‐X‐C motif chemokine ligand 13 and interleukin‐8 in predicting the transition from clinically isolated syndrome to multiple sclerosis. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Klíčová, Kateřina – PersonEntity: Name: NameFull: Mareš, Jan – PersonEntity: Name: NameFull: Sobek, Ondřej – PersonEntity: Name: NameFull: Rous, Zuzana – PersonEntity: Name: NameFull: Rous, Matouš – PersonEntity: Name: NameFull: Raška, Milan – PersonEntity: Name: NameFull: Hartung, Hans‐Peter IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 06 Text: Jun2024 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 0953816X Numbering: – Type: volume Value: 59 – Type: issue Value: 11 Titles: – TitleFull: European Journal of Neuroscience Type: main |
| ResultId | 1 |
