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The impact of multimorbidity and functional limitation on quality of life in patients with heart failure: A multi‐site study.

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Title: The impact of multimorbidity and functional limitation on quality of life in patients with heart failure: A multi‐site study.
Authors: Manemann, Sheila M., Hade, Erinn M., Haller, Irina V., Horne, Benjamin D., Benziger, Catherine P., Lampert, Brent C., Rasmusson, Kismet D., Roger, Veronique L., Weston, Susan A., Killian, Jill M., Chamberlain, Alanna M.
Source: Journal of the American Geriatrics Society. Jun2024, Vol. 72 Issue 6, p1750-1759. 10p.
Subjects: Research funding, Fatigue (Physiology), Functional status, Heart failure, Treatment effectiveness, Anxiety, Descriptive statistics, Odds ratio, Quality of life, Research, Sleep, Pain, Confidence intervals, Comparative studies, Comorbidity, Activities of daily living, Mental depression
Abstract: Background: Multimorbidity and functional limitation are associated with poor outcomes in heart failure (HF). However, the individual and combined effect of these on health‐related quality of life in patients with HF is not well understood. Methods: Patients aged ≥30 years with two or more HF diagnostic codes and one or more HF‐related prescription drugs from four U.S. institutions were mailed a survey to measure patient‐centric factors including functional status (activities of daily living [ADLs]) and health‐related quality of life (PROMIS‐29 Health Profile). Patients with HF from January 1, 2013 to February 1, 2018 were included. Multimorbidity was defined as ≥2 non‐cardiovascular comorbidities; functional limitation as any limitation in at least one of eight ADLs. Patients were categorized into four groups by multimorbidity (Yes/No) and functional limitation (Yes/No). We dichotomized the PROMIS‐29 sub‐scale scores at the median and calculated odd ratios for the four multimorbidity/functional limitation groups. Results: A total of 3330 patients with HF returned the survey (response rate 31%); 3020 completed the questions of interest and were retained. Among these patients (45% female; mean age 73 [standard deviation: 12] years), 29% had neither multimorbidity nor functional limitation, 24% had multimorbidity only, 22% had functional limitation only, and 25% had both. After adjustment, having functional limitation only was associated with higher anxiety (odds ratio [OR]: 3.44, 95% confidence interval [CI]: 2.66–4.45), depression (OR: 3.11, 95% CI: 2.39–4.06), and fatigue (OR: 4.19, 95% CI: 3.25–5.40); worse sleep (OR: 2.14, 95% CI: 1.69–2.72) and pain (OR: 6.73, 95% CI: 5.15–8.78); and greater difficulty with social activities (OR: 9.40, 95% CI: 7.19–12.28) compared with having neither. Results were similar for having both multimorbidity and functional limitation. Conclusion: Patients with only functional limitation have similar poor health‐related quality of life scores as those with both multimorbidity and functional limitation, underscoring the important role that physical functioning plays in the well‐being of patients with HF. [ABSTRACT FROM AUTHOR]
Copyright of Journal of the American Geriatrics Society is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: The impact of multimorbidity and functional limitation on quality of life in patients with heart failure: A multi‐site study.
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  Data: <searchLink fieldCode="AR" term="%22Manemann%2C+Sheila+M%2E%22">Manemann, Sheila M.</searchLink><br /><searchLink fieldCode="AR" term="%22Hade%2C+Erinn+M%2E%22">Hade, Erinn M.</searchLink><br /><searchLink fieldCode="AR" term="%22Haller%2C+Irina+V%2E%22">Haller, Irina V.</searchLink><br /><searchLink fieldCode="AR" term="%22Horne%2C+Benjamin+D%2E%22">Horne, Benjamin D.</searchLink><br /><searchLink fieldCode="AR" term="%22Benziger%2C+Catherine+P%2E%22">Benziger, Catherine P.</searchLink><br /><searchLink fieldCode="AR" term="%22Lampert%2C+Brent+C%2E%22">Lampert, Brent C.</searchLink><br /><searchLink fieldCode="AR" term="%22Rasmusson%2C+Kismet+D%2E%22">Rasmusson, Kismet D.</searchLink><br /><searchLink fieldCode="AR" term="%22Roger%2C+Veronique+L%2E%22">Roger, Veronique L.</searchLink><br /><searchLink fieldCode="AR" term="%22Weston%2C+Susan+A%2E%22">Weston, Susan A.</searchLink><br /><searchLink fieldCode="AR" term="%22Killian%2C+Jill+M%2E%22">Killian, Jill M.</searchLink><br /><searchLink fieldCode="AR" term="%22Chamberlain%2C+Alanna+M%2E%22">Chamberlain, Alanna M.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+the+American+Geriatrics+Society%22">Journal of the American Geriatrics Society</searchLink>. Jun2024, Vol. 72 Issue 6, p1750-1759. 10p.
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  Data: <searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Fatigue+%28Physiology%29%22">Fatigue (Physiology)</searchLink><br /><searchLink fieldCode="DE" term="%22Functional+status%22">Functional status</searchLink><br /><searchLink fieldCode="DE" term="%22Heart+failure%22">Heart failure</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+effectiveness%22">Treatment effectiveness</searchLink><br /><searchLink fieldCode="DE" term="%22Anxiety%22">Anxiety</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Odds+ratio%22">Odds ratio</searchLink><br /><searchLink fieldCode="DE" term="%22Quality+of+life%22">Quality of life</searchLink><br /><searchLink fieldCode="DE" term="%22Research%22">Research</searchLink><br /><searchLink fieldCode="DE" term="%22Sleep%22">Sleep</searchLink><br /><searchLink fieldCode="DE" term="%22Pain%22">Pain</searchLink><br /><searchLink fieldCode="DE" term="%22Confidence+intervals%22">Confidence intervals</searchLink><br /><searchLink fieldCode="DE" term="%22Comparative+studies%22">Comparative studies</searchLink><br /><searchLink fieldCode="DE" term="%22Comorbidity%22">Comorbidity</searchLink><br /><searchLink fieldCode="DE" term="%22Activities+of+daily+living%22">Activities of daily living</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: Multimorbidity and functional limitation are associated with poor outcomes in heart failure (HF). However, the individual and combined effect of these on health‐related quality of life in patients with HF is not well understood. Methods: Patients aged ≥30 years with two or more HF diagnostic codes and one or more HF‐related prescription drugs from four U.S. institutions were mailed a survey to measure patient‐centric factors including functional status (activities of daily living [ADLs]) and health‐related quality of life (PROMIS‐29 Health Profile). Patients with HF from January 1, 2013 to February 1, 2018 were included. Multimorbidity was defined as ≥2 non‐cardiovascular comorbidities; functional limitation as any limitation in at least one of eight ADLs. Patients were categorized into four groups by multimorbidity (Yes/No) and functional limitation (Yes/No). We dichotomized the PROMIS‐29 sub‐scale scores at the median and calculated odd ratios for the four multimorbidity/functional limitation groups. Results: A total of 3330 patients with HF returned the survey (response rate 31%); 3020 completed the questions of interest and were retained. Among these patients (45% female; mean age 73 [standard deviation: 12] years), 29% had neither multimorbidity nor functional limitation, 24% had multimorbidity only, 22% had functional limitation only, and 25% had both. After adjustment, having functional limitation only was associated with higher anxiety (odds ratio [OR]: 3.44, 95% confidence interval [CI]: 2.66–4.45), depression (OR: 3.11, 95% CI: 2.39–4.06), and fatigue (OR: 4.19, 95% CI: 3.25–5.40); worse sleep (OR: 2.14, 95% CI: 1.69–2.72) and pain (OR: 6.73, 95% CI: 5.15–8.78); and greater difficulty with social activities (OR: 9.40, 95% CI: 7.19–12.28) compared with having neither. Results were similar for having both multimorbidity and functional limitation. Conclusion: Patients with only functional limitation have similar poor health‐related quality of life scores as those with both multimorbidity and functional limitation, underscoring the important role that physical functioning plays in the well‐being of patients with HF. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of the American Geriatrics Society is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=177946640
RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1111/jgs.18924
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        Text: English
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        PageCount: 10
        StartPage: 1750
    Subjects:
      – SubjectFull: Research funding
        Type: general
      – SubjectFull: Fatigue (Physiology)
        Type: general
      – SubjectFull: Functional status
        Type: general
      – SubjectFull: Heart failure
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      – SubjectFull: Treatment effectiveness
        Type: general
      – SubjectFull: Anxiety
        Type: general
      – SubjectFull: Descriptive statistics
        Type: general
      – SubjectFull: Odds ratio
        Type: general
      – SubjectFull: Quality of life
        Type: general
      – SubjectFull: Research
        Type: general
      – SubjectFull: Sleep
        Type: general
      – SubjectFull: Pain
        Type: general
      – SubjectFull: Confidence intervals
        Type: general
      – SubjectFull: Comparative studies
        Type: general
      – SubjectFull: Comorbidity
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      – SubjectFull: Activities of daily living
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      – SubjectFull: Mental depression
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      – TitleFull: The impact of multimorbidity and functional limitation on quality of life in patients with heart failure: A multi‐site study.
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              Text: Jun2024
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