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Structural basis of odor sensing by insect heteromeric odorant receptors.

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Title: Structural basis of odor sensing by insect heteromeric odorant receptors.
Authors: Zhao, Jiawei, Chen, Andy Q., Ryu, Jaewook, del Mármol, Josefina
Source: Science (pre-March 2025). 6/28/2024, Vol. 384 Issue 6703, p1460-1467. 8p. 4 Diagrams.
Subjects: Olfactory receptors, Anopheles gambiae, Insects, Insect evolution, Ion channels, Mosquitoes, Aedes aegypti, Mosquito control
Abstract: Most insects, including human-targeting mosquitoes, detect odors through odorant-activated ion channel complexes consisting of a divergent odorant-binding subunit (OR) and a conserved co-receptor subunit (Orco). As a basis for understanding how odorants activate these heteromeric receptors, we report here cryo2electron microscopy structures of two different heteromeric odorant receptor complexes containing ORs from disease-vector mosquitos Aedes aegypti or Anopheles gambiae. These structures reveal an unexpected stoichiometry of one OR to three Orco subunits. Comparison of structures in odorant-bound and unbound states indicates that odorant binding to the sole OR subunit is sufficient to open the channel pore, suggesting a mechanism of OR activation and a conceptual framework for understanding evolution of insect odorant receptor sensitivity. [ABSTRACT FROM AUTHOR]
Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Structural basis of odor sensing by insect heteromeric odorant receptors.
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  Data: <searchLink fieldCode="AR" term="%22Zhao%2C+Jiawei%22">Zhao, Jiawei</searchLink><br /><searchLink fieldCode="AR" term="%22Chen%2C+Andy+Q%2E%22">Chen, Andy Q.</searchLink><br /><searchLink fieldCode="AR" term="%22Ryu%2C+Jaewook%22">Ryu, Jaewook</searchLink><br /><searchLink fieldCode="AR" term="%22del+Mármol%2C+Josefina%22">del Mármol, Josefina</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 6/28/2024, Vol. 384 Issue 6703, p1460-1467. 8p. 4 Diagrams.
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  Data: <searchLink fieldCode="DE" term="%22Olfactory+receptors%22">Olfactory receptors</searchLink><br /><searchLink fieldCode="DE" term="%22Anopheles+gambiae%22">Anopheles gambiae</searchLink><br /><searchLink fieldCode="DE" term="%22Insects%22">Insects</searchLink><br /><searchLink fieldCode="DE" term="%22Insect+evolution%22">Insect evolution</searchLink><br /><searchLink fieldCode="DE" term="%22Ion+channels%22">Ion channels</searchLink><br /><searchLink fieldCode="DE" term="%22Mosquitoes%22">Mosquitoes</searchLink><br /><searchLink fieldCode="DE" term="%22Aedes+aegypti%22">Aedes aegypti</searchLink><br /><searchLink fieldCode="DE" term="%22Mosquito+control%22">Mosquito control</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Most insects, including human-targeting mosquitoes, detect odors through odorant-activated ion channel complexes consisting of a divergent odorant-binding subunit (OR) and a conserved co-receptor subunit (Orco). As a basis for understanding how odorants activate these heteromeric receptors, we report here cryo2electron microscopy structures of two different heteromeric odorant receptor complexes containing ORs from disease-vector mosquitos Aedes aegypti or Anopheles gambiae. These structures reveal an unexpected stoichiometry of one OR to three Orco subunits. Comparison of structures in odorant-bound and unbound states indicates that odorant binding to the sole OR subunit is sufficient to open the channel pore, suggesting a mechanism of OR activation and a conceptual framework for understanding evolution of insect odorant receptor sensitivity. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=178109526
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      – Type: doi
        Value: 10.1126/science.adn6384
    Languages:
      – Code: eng
        Text: English
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      Pagination:
        PageCount: 8
        StartPage: 1460
    Subjects:
      – SubjectFull: Olfactory receptors
        Type: general
      – SubjectFull: Anopheles gambiae
        Type: general
      – SubjectFull: Insects
        Type: general
      – SubjectFull: Insect evolution
        Type: general
      – SubjectFull: Ion channels
        Type: general
      – SubjectFull: Mosquitoes
        Type: general
      – SubjectFull: Aedes aegypti
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      – SubjectFull: Mosquito control
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      – TitleFull: Structural basis of odor sensing by insect heteromeric odorant receptors.
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            NameFull: Zhao, Jiawei
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            NameFull: Chen, Andy Q.
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            NameFull: Ryu, Jaewook
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            NameFull: del Mármol, Josefina
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            – D: 28
              M: 06
              Text: 6/28/2024
              Type: published
              Y: 2024
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              Value: 384
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